Data as of Oct 28, 2026.

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Across categories

IBB vs IYR: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to IYR's +3.4%, and IYR charges 0.37% to IBB's 0.44%.

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Net assets: $11.0bn on Oct 27, 2026 for iShares Biotechnology ETF, and $3.9bn on Oct 28, 2026 for iShares U.S. Real Estate ETF.

At a glance
+37.5%
IBB total return, 1 year
+3.4%
IYR total return, 1 year
0.44%
IBB expense ratio
0.37%
IYR expense ratio

Pair scorecard

IYR costs 0.07 points a year less; their one-year returns differ by 34.1 points; IBB is 2.7 times larger.

IBB vs IYR: Differences, Returns & Fees
MeasureIBBIYR
Return
Total return, 1 year+37.5%+3.4%
Drawdown
Below its high8.6%, high on Jul 28, 2026
Benchmark
What it tracksBiotechDow Jones U.S. Real Estate Capped Index
Cost and size
Expense ratio0.44%0.37%
Net assets, as of Oct 26, 2026$10.7bn$4.0bn
Active share vs the S&P 50099%
Holdings
Holdings in common0%
Top ten holdings, share of the fund50%52.5%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

0%

By the books each fund has filed, IBB and IYR hold 0% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

0% in common

Positions both hold · largest shared weight first IBB IYR
Only in one fund ↓
Only in IBB
GILEAD SCIENCES 8.56%
AMGEN INC 8.20%
VERTEX PHARMACEUTICALS 7.53%
REGENERON PHARMACEUTICALS 5.64%
MODERNA 5.29%
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
Only in IYR
WELLTOWER 9.85%
PROLOGIS REIT 8.77%
AMERICAN TOWER REIT 4.96%
SIMON PROPERTY GROUP REIT INC 4.71%
EQUINIX REIT 4.57%
DIGITAL REALTY TRUST REIT 4.54%
REALTY INCOME REIT 4.19%
PUBLIC STORAGE REIT 4.10%
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Side by side

IBB iShares Biotechnology ETF IYR iShares U.S. Real Estate ETF
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks an index of U.S. Real Estate
Total return, 1 year +37.5% +3.4%
Expense ratio 0.44% 0.37%
Already in the S&P 500 40.2% 80.0%
Holdings 245 59
Net assets, IBB as of Oct 27, 2026 and IYR as of Oct 28, 2026 $11.0bn $3.9bn

IBB and IYR on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

IYR

IYR tracks an index of U.S. Real Estate. Over the year to Oct 28, 2026 it returned +3.4% with distributions reinvested. The prospectus expense ratio is 0.37% a year. By its holdings published by its issuer for Oct 27, 2026, 80% of the fund by weight is stocks the S&P 500 also holds, across 59 positions, with the top ten at 52.5%. It sat 8.6% below its high of Jul 28, 2026 on Oct 28, 2026.

Questions people ask

Are IBB and IYR in the same category?
IBB is a thematic ETF and IYR is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or IYR?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and IYR +3.4%.
Which is cheaper, IBB or IYR?
IYR is cheaper, by 0.07 percentage points a year. That is about $7 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and IYR overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 80% of IYR by weight is stocks the S&P 500 already holds.
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ETFIQ, IBB against IYR, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-iyr

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