Data as of Oct 28, 2026.

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Across categories

BOXX vs XBI: Differences, Returns & Fees

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Over the year to Oct 28, 2026, BOXX returned +4.0% to XBI's +41.2%, and BOXX charges 0.19% to XBI's 0.35%.

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Net assets: $14.5bn on Oct 28, 2026 for Alpha Architect 1-3 Month Box ETF, and $10.3bn on Oct 27, 2026 for State Street SPDR S&P Biotech ETF.

At a glance
+4.0%
BOXX total return, 1 year
+41.2%
XBI total return, 1 year
0.19%
BOXX expense ratio
0.35%
XBI expense ratio

Pair scorecard

BOXX costs 0.16 points a year less; their one-year returns differ by 37.2 points; BOXX is 1.4 times larger.

BOXX vs XBI: Differences, Returns & Fees
MeasureBOXXXBI
Return
Total return, 1 year+4.0%+41.2%
Drawdown
Below its all-time high8.9%, high on Feb 8, 2021
Benchmark
What it tracksNo index, actively managedBiotech
Cost and size
Expense ratio0.19%0.35%
Net assets, as of Oct 26, 2026$14.4bn$10.2bn
Active share vs the S&P 50098%
Holdings
Holdings in commonnot published
In the S&P 500, by weight13%
Top ten holdings, share of the fund18%

Method

Side by side

BOXX Alpha Architect 1-3 Month Box ETF XBI State Street SPDR S&P Biotech ETF
Where it sits Bond ETF Thematic ETF
What it is Actively managed Biotech
Total return, 1 year +4.0% +41.2%
Expense ratio 0.19% 0.35%
Holdings not counted 165
Net assets, BOXX as of Oct 28, 2026 and XBI as of Oct 27, 2026 $14.5bn $10.3bn

BOXX and XBI on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
BOXX

BOXX is actively managed and tracks no index. Over the year to Oct 28, 2026 it returned +4.0% with distributions reinvested. The prospectus expense ratio is 0.19% a year.

XBI

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.

Questions people ask

Are BOXX and XBI in the same category?
BOXX is a bond ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, BOXX or XBI?
In the year to Oct 28, 2026, with distributions reinvested, BOXX returned +4.0% and XBI +41.2%.
Which is cheaper, BOXX or XBI?
BOXX is cheaper, by 0.16 percentage points a year. That is about $16 on $10,000 held for a year. Fees come from each fund's prospectus.
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ETFIQ, BOXX against XBI, data as of Oct 28, 2026. https://etfiq.com/compare/any/boxx-vs-xbi

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