As of Nov 4, 2026. Rebuilt every trading night.
The genomics ETFs least like the S&P 500
See 4 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on genomics. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.
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All 4, lowest first
4 of 4 · click a column to sort| # | Ticker | Fund | Weight in S&P 500 companies ↑ | Active share | Net assets | Fee |
|---|---|---|---|---|---|---|
| 1 | ARKG | ARK Genomic Revolution ETF | 4.6% | 98.5% | $2.1bn | 0.75% |
| 2 | GNOM | Global X Genomics & Biotechnology ETF | 21.0% | 97.6% | $104m | 0.50% |
| 3 | IDNA | iShares Genomics Immunology and Healthca | 27.4% | 99.1% | $340m | 0.47% |
| 4 | GNMX | Corgi Genomics & Precision Medicine ETF | 31.0% | 99.4% | $1.3m | 0.35% |
The 4 of 4 ETFs in the genomics and gene editing theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 4.6% to 31.0%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
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ETFIQ, The genomics ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-genomics
ETFIQ. (Nov 4, 2026). The genomics ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-genomics
[The genomics ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-off-index-genomics)
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