Ranked by net assets, as of . Rebuilt every trading night.
The largest biotech and genomics ETFs
Every fund here is sold on biotech and genomics. What each one holds, and how much of it the S&P 500 already holds for you, is the column beside the size.
| # | Ticker | Fund | Net assets | Weight in S&P 500 companies | Total return, 1Y | Fee | Source |
|---|---|---|---|---|---|---|---|
| 1 | FBT | First Trust NYSE Arca Biotechnology Inde | $2.8bn | 24.0% | +46.5% | 0.55% | SEC filing, whole fund |
| 2 | ARKG | ARK Genomic Revolution ETF | $1.2bn | 3.9% | +74.0% | 0.75% | SEC filing, whole fund |
| 3 | BBH | VanEck Biotech ETF | $396m | 60.7% | +36.1% | 0.35% | SEC filing, whole fund |
| 4 | PBE | Invesco Biotechnology & Genome ETF | $247m | 30.1% | +32.5% | 0.59% | SEC filing, whole fund |
| 5 | IDNA | iShares Genomics Immunology and Healthca | $160m | 23.8% | +65.8% | 0.47% | SEC filing, whole fund |
| 6 | IBBQ | Invesco Nasdaq Biotechnology ETF | $67m | 38.1% | +43.5% | 0.19% | SEC filing, whole fund |
| 7 | BBP | Virtus Biotech ETF | $59m | 12.4% | +47.0% | 0.34% | SEC filing, whole fund |
| 8 | GNOM | Global X Genomics & Biotechnology ETF | $56m | 21.5% | +69.7% | 0.50% | SEC filing, whole fund |
| 9 | BBC | Virtus Biotech Clinical Trials ETF | $37m | 0.0% | +103.2% | 0.65% | SEC filing, whole fund |
| 10 | PBPH | Portfolio Building Block World Pharma an | $36m | 56.8% | too new | 0.13% | SEC filing, whole fund |
Method
The 12 ETFs in the biotech and genomics theme, of which 10 publish net assets, ranked on the most recent figure for each. Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 60.7%. Size is not a measure of anything a fund did. It is where the money is. The ranking is the published field sorted, nothing else: no scoring, no weighting and no view on any fund. Every fund ETFIQ covers in this category is eligible, including funds that have closed, because leaving them out would flatter the category.
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Where these figures came from
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A ranking is not a recommendation and no order on this site is an opinion. ETFIQ is an independent publisher, not an adviser. Standards and sources
Cite this page. ETFIQ, The largest biotech and genomics ETFs, ranked by net assets, data as of Sep 11, 2026. https://etfiq.com/rankings/themes-largest-genomics Free to use with attribution; the underlying files are at Open data.