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QTUM vs XBI: which is really different?

QTUM and XBI hold 0% of their weight in the same names, and XBI returned +45.0% over the year. Defiance Quantum ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

XBI costs 0.05 points a year less; their one-year returns differ by 8.0 points; XBI is 1.7 times larger.

QTUMXBI
Expense ratio0.40%0.35%
Net assets, as of Oct 8, 2026$5.7bn$9.9bn
Total return, 1 year+37.0%+45.0%
What it tracksQuantum computingBiotech
Holdings in common0%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 19.8 ptsahead by 27.7 pts
Active share vs the S&P 50082%
Below its all-time high9.5%, high on Jun 2, 202611.1%, high on Feb 8, 2021

Holdings in common uses holdings dated Oct 8, 2026.

35.7%
QTUM in the S&P 500
12.7%
XBI in the S&P 500
+37.0%
QTUM total return, 1 year
+45.0%
XBI total return, 1 year
QTUM · 1 year to Oct 9, 202664% of its weight is outside the S&P 500
64% of its weight is outside the S&P 50036% of QTUM's weight is in S&P 500 companies and 64% is outside the index. Holdings as of Oct 8, 2026.36%64%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 83% · top ten 18% of the fund · 86 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 28% in64% of its weight is outside the S&P 50036% of QTUM's weight is in S&P 500 companies and 64% is outside the index. Holdings as of Oct 8, 2026.36%64%inoutside the S&P 500active share 83% · Nasdaq-100: 28% in

36% of QTUM's weight is in S&P 500 companies and 64% is outside the index. Holdings as of Oct 8, 2026.

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500
87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · top ten 17% of the fund · 165 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 9% in87% of its weight is outside the S&P 50013% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.13%87%inof its weight outside the S&P 500active share 98% · Nasdaq-100: 9% in

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · XBI scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, QTUM and XBI hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 8, 2026.

half

0% in common

Positions both hold, largest shared weight first
Holding QTUM XBI
Only in QTUM
Global Unichip Corp 2.35%
Horizon Quantum Holdings Ltd 1.88%
Elastic Nv 1.81%
Cloudflare Inc 1.80%
Hewlett Packard Enterprise Co 1.80%
Palantir Technologies Inc 1.76%
Nutanix Inc 1.70%
Snowflake Inc 1.65%
Only in XBI
MODERNA INC 2.20%
TWIST BIOSCIENCE CORP 1.84%
NATERA INC 1.79%
ABBVIE INC 1.65%
UNITED THERAPEUTICS CORP 1.59%
AMGEN INC 1.58%
BIOGEN INC 1.57%
HALOZYME THERAPEUTICS INC 1.55%

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowQTUMXBIQTUMXBIQTUMXBI
3 months−1.3%−3.3%−4.6 pts−6.7 pts−4.9 pts−7.0 pts
6 months+30.9%+18.9%+15.8 pts+3.8 pts+7.7 pts−4.3 pts
1 year+37.0%+45.0%+19.8 pts+27.7 pts+13.4 pts+21.4 pts
3 years+220.5%+114.6%+134.8 pts+28.8 pts+113.3 pts+7.3 pts
Since launch
QTUM Sep 2018 · XBI Feb 2006
+558.2%+890.7%+353.0 pts+92.2 pts+226.3 pts−1,164.7 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

QTUM
Defiance Quantum ETF · Holds 86 stocks in quantum computing, 36% of its weight in S&P 500 companies
XBI
State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies
Issuer Defiance State Street
Theme Quantum computing Biotech
In the S&P 500 35.7% 12.7%
Active share vs the S&P 500 82.5% 98.4%
In the Nasdaq-100 28.4% 8.5%
Holdings 86 165
Top ten, share of the fund 18.0% 16.9%
Expense ratio 0.40% 0.35%
Fee for the differing part 0.48% 0.36%
Total return, 1 year +37.0% +45.0%
vs the S&P 500 +19.8 pts +27.7 pts
vs the Nasdaq-100 +13.4 pts +21.4 pts
Below its high −9.5% −11.1%
Net assets, as of Oct 8, 2026 $5.7bn $9.9bn

As of Oct 9, 2026. Source: ETFIQ.

QTUM in plain words

By weight, 36% of QTUM's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 82%. The top ten holdings are 18% of the fund across 86 positions, as published by its issuer for Oct 9, 2026. Over the year to Oct 9, 2026 the fund returned +37.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 19.8 pts. It sits 9.5% below its all-time high of Jun 2, 2026.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

Questions people ask

Do QTUM and XBI hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, QTUM or XBI?
QTUM has 36% of its weight in S&P 500 names and XBI has 13%, so XBI differs more from the index.
Which is cheaper, QTUM or XBI?
QTUM charges 0.40% a year and XBI charges 0.35%, so XBI is cheaper. Fees come from each fund's prospectus.
Other comparisons
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QTUM on its own →XBI on its own →How every figure is computed →Standards and sources →
Where these figures came from
QTUM filings on SEC EDGAR ↗QTUM prospectus with the expense ratio (SEC) ↗Defiance page for QTUM ↗XBI filings on SEC EDGAR ↗XBI prospectus with the expense ratio (SEC) ↗State Street website ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, QTUM against XBI, data as of Oct 9, 2026. https://etfiq.com/compare/themes/qtum-vs-xbi

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.