Data as of .
LFSC vs TNXT: which is really different?
LFSC and TNXT hold 3% of their weight in the same names.
ETFIQ Off-Index Score: LFSC scores higher
How much of it is not the index it is sold as an alternative to?
A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed
3% of the two portfolios are the same securities at the same weight.
What they hold in common
By the books each fund has filed, LFSC and TNXT hold 3% of their money in the same securities at the same weight.
| Holding | LFSC | TNXT |
|---|---|---|
| Guardant Health Inc | 5.51% | 0.70% |
| Spyre Therapeutics Inc | 6.41% | 0.33% |
| Twist Bioscience Corp | 1.14% | 0.27% |
| Billiontoone Inc | 2.73% | 0.25% |
| Dianthus Therapeutics Inc | 3.09% | 0.21% |
| Insmed Inc | 0.61% | 0.18% |
| Cytokinetics Inc | 3.16% | 0.14% |
| United Therapeutics Corp | 4.15% | 0.14% |
| Axsome Therapeutics Inc | 2.84% | 0.12% |
| Mirum Pharmaceuticals Inc | 4.92% | 0.11% |
| Palvella Therapeutics Inc | 1.95% | 0.10% |
| Viridian Therapeutics Inc | 2.23% | 0.10% |
| Only in LFSC | Only in TNXT |
|---|---|
| Travere Therapeutics Inc 7.66% | NVIDIA CORP 7.23% |
| Cogent Biosciences Inc 7.52% | APPLE INC 4.61% |
| LivaNova PLC 7.11% | AMAZON.COM INC 3.02% |
| Corcept Therapeutics Inc 4.79% | BROADCOM INC 2.76% |
| VeraDermics Inc 3.42% | MICROSOFT CORP 2.67% |
| Savara Inc 3.22% | ALPHABET INC CL A 2.57% |
| Nektar Therapeutics 3.14% | ADVANCED MICRO DEVICES 2.53% |
| Trevi Therapeutics Inc 3.12% | ALPHABET INC CL C 2.28% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.
Performance, window by window
| Window | Total return | vs the S&P 500 | vs the Nasdaq-100 | |||
|---|---|---|---|---|---|---|
| LFSC | TNXT | LFSC | TNXT | LFSC | TNXT | |
| 3 months | +8.7% | +3.8% | +6.5 pts | +1.6 pts | +11.2 pts | +6.3 pts |
| 6 months | +36.0% | +27.4% | +17.9 pts | +9.3 pts | +11.7 pts | +3.1 pts |
| 1 year | +53.0% | not published | +36.5 pts | not published | +31.3 pts | not published |
| Since launch | +81.3% | +14.5% | +44.3 pts | +3.9 pts | +30.9 pts | −0.4 pts |
| LFSC F/m Emerald Life Sciences Innovation ETF Holds 39 stocks in broad innovation and megatrends, 0% of its weight in S&P 500 companies | TNXT T. Rowe Price Innovation Leaders ETF Holds 272 stocks in broad innovation and megatrends, 64% of its weight in S&P 500 companies | |
|---|---|---|
| Issuer | F/m | T. Rowe Price |
| Theme | Broad innovation and megatrends | Broad innovation and megatrends |
| In the S&P 500 | 0.0% | 64.3% |
| Active share vs the S&P 500 | 100.0% | 51.6% |
| In the Nasdaq-100 | 0.6% | 46.9% |
| Holdings | 39 | 272 |
| Top ten, share of the fund | 54.7% | 31.8% |
| Expense ratio | 0.54% | 0.49% |
| Fee for the differing part | 0.54% | 0.95% |
| Total return, 1 year | +53.0% | +14.5% (since launch on Jan 29, 2026) |
| vs the S&P 500 | +36.5 pts | +3.9 pts |
| vs the Nasdaq-100 | +31.3 pts | −0.4 pts |
| Below its high | −6.8% | −1.4% |
| Net assets | $105m | $18m |
LFSC in plain words
By weight, 0% of LFSC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 55% of the fund across 39 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +53.0% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 36.5 pts. It sits 6.8% below its all-time high of Aug 19, 2026.
TNXT in plain words
By weight, 64% of TNXT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 52%. The top ten holdings are 32% of the fund across 272 positions, as filed for Jun 30, 2026. Since it launched on Jan 29, 2026 the fund returned +14.5% with distributions reinvested against +10.6% for the S&P 500, so a holder was ahead by 3.9 pts.
Questions people ask
- Do LFSC and TNXT hold the same stocks?
- By their latest filings, 3% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
- Which is more different from the S&P 500, LFSC or TNXT?
- LFSC has 0% of its weight in S&P 500 names and TNXT has 64%, so LFSC differs more from the index.
- Which is cheaper, LFSC or TNXT?
- LFSC charges 0.54% a year and TNXT charges 0.49%, so TNXT is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, LFSC against TNXT, data as of Sep 18, 2026. https://etfiq.com/compare/themes/lfsc-vs-tnxt Free to use with attribution; the underlying files are at Open data.