Data as of Nov 4, 2026.

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Thematic ETFs

GDOC vs LFSC: Holdings Overlap & Returns

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Over the year to Nov 4, 2026, GDOC returned +15.5% to LFSC's +43.6%; 8% of their weight is in the same names.

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Net assets: $20m on Nov 3, 2026 for Goldman Sachs Future Health Care Equity ETF, and $126m on Aug 31, 2026 for F/m Emerald Life Sciences Innovation ETF.

At a glance
62.5%
GDOC in the S&P 500
0.0%
LFSC in the S&P 500
+15.5%
GDOC total return, 1 year
+43.6%
LFSC total return, 1 year
GDOC · 1 year to Nov 4, 2026 38% of its weight is outside the S&P 500
38% of its weight is outside the S&P 50063% of GDOC's weight is in S&P 500 companies and 38% is outside the index. Holdings as of Aug 31, 2026.63%38%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 95% · top ten 57% of the fund · 39 holdings as filed for Aug 31, 2026 · Nasdaq-100: 11% in38% of its weight is outside the S&P 50063% of GDOC's weight is in S&P 500 companies and 38% is outside the index. Holdings as of Aug 31, 2026.63%38%in the S&P 500outsideactive share 95% · Nasdaq-100: 11% in

63% of GDOC's weight is in S&P 500 companies and 38% is outside the index. Holdings as of Aug 31, 2026.

LFSC · 1 year to Nov 4, 2026 100% of its weight is outside the S&P 500
100% of its weight is outside the S&P 5000% of LFSC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Aug 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 54% of the fund · 38 holdings as filed for Aug 31, 2026 · Nasdaq-100: 0% in100% of its weight is outside the S&P 5000% of LFSC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Aug 31, 2026.0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · Nasdaq-100: 0% in

0% of LFSC's weight is in S&P 500 companies and 100% is outside the index. Holdings as of Aug 31, 2026.

Pair scorecard

LFSC costs 0.21 points a year less; their one-year returns differ by 28.1 points.

Points (pts) are percentage points.

GDOC vs LFSC: Holdings Overlap & Returns
MeasureGDOCLFSC
Return
Total return, 1 year+15.5%+43.6%
Drawdown
Below its all-time high5.7%, high on Aug 19, 2026
Against its benchmark
What it tracksBroad innovation and megatrendsBroad innovation and megatrends
Its benchmark, total return, 1 year+14.8%
Against its benchmark, 1 yearahead by 28.8 pts
Cost and size
Expense ratio0.75%0.54%
Net assets, GDOC as of Nov 3, 2026 and LFSC as of Aug 31, 2026$20m$126m
Holdings
Holdings in common8%

Method

What they share

8%

By the books each fund has filed, GDOC and LFSC hold 8% of their money in the same securities at the same weight. Holdings dated Aug 31, 2026.

0 half 100%

half

8% in common

Positions both hold · largest shared weight first GDOC LFSC
GUARDANT HEALTH INC 4.02% 3.81%
CYTOKINETICS INC 1.58% 3.50%
DIANTHUS THERAPEUTICS INC 0.95% 2.70%
SPYRE THERAPEUTICS INC 0.77% 6.70%
PRAXIS PRECISION MEDICINES INC 0.73% 0.98%
INSMED INC 1.13% 0.60%
Only in one fund ↓
Only in GDOC
ELI LILLY & COMPANY 12.20%
JOHNSON & JOHNSON 8.31%
MERCK & COMPANY INC 7.43%
UNITEDHEALTH GROUP INC 5.79%
VERTEX PHARMACEUTICALS INC 4.20%
ARGENX SE 4.14%
DEXCOM INC 3.87%
AGILENT TECHNOLOGIES INC 3.51%
Only in LFSC
Travere Therapeutics Inc 8.71%
Corcept Therapeutics Inc 6.72%
LivaNova PLC 6.61%
Cogent Biosciences Inc 6.48%
Mirum Pharmaceuticals Inc 4.32%
Billiontoone Inc 3.86%
United Therapeutics Corp 3.27%
Axsome Therapeutics Inc 3.05%
Check overlap with more funds →

Window by window

Window by window: GDOC vs LFSC: Holdings Overlap & Returns
Total returnvs its benchmark
WindowGDOCLFSCGDOCLFSC
3 months+9.2%−3.8%not measured−3.5 pts vs IWV
6 months+23.1%+16.9%not measured+12.0 pts vs IWV
1 year+15.5%+43.6%not measured+28.8 pts vs IWV
3 years+37.3%–not measured–
Since launchNot the same days: GDOC Nov 2021 · LFSC Oct 2024+2.6%+83.4%not measured+46.4 pts vs IWV

– means no data for this window. Open this comparison in the app →

Side by side

GDOC Goldman Sachs Future Health Care Equity ETF · Holds 39 stocks in broad innovation and megatrends, 62% of its weight in S&P 500 companies LFSC F/m Emerald Life Sciences Innovation ETF · Holds 38 stocks in broad innovation and megatrends, 0% of its weight in S&P 500 companies
Theme Broad innovation and megatrends Broad innovation and megatrends
In the S&P 500 62.5% 0.0%
Active share vs the S&P 500 95.4% 100.0%
In the Nasdaq-100 11.0% 0.0%
Holdings 39 38
Top ten, share of the fund 57.0% 54.0%
Expense ratio 0.75% 0.54%
Fee for the differing part 0.79% 0.54%
Total return, 1 year +15.5% +43.6%
vs its benchmark not measured +28.8 pts vs IWV
Below its high 0.0% −5.7%
Net assets, GDOC as of Nov 3, 2026 and LFSC as of Aug 31, 2026 $20m $126m

As of Nov 4, 2026. Source: ETFIQ.

8% of the two portfolios are the same securities at the same weight.

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About each fund
GDOC

By weight, 62% of GDOC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 95%. The top ten holdings are 57% of the fund across 39 positions, as filed for Aug 31, 2026. Over the year to Nov 4, 2026 the fund returned +15.5% with distributions reinvested.

LFSC

Over the year to Nov 4, 2026 the fund returned +43.6% with distributions reinvested against +14.8% for its benchmark, the Russell 3000 Total Return, so a holder was ahead by 28.8 pts.

By weight, 0% of LFSC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 54% of the fund across 38 positions, as filed for Aug 31, 2026. It sits 5.7% below its all-time high of Aug 19, 2026.

Questions people ask

Do GDOC and LFSC hold the same stocks?
By their latest filings, 8% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, GDOC or LFSC?
GDOC has 62% of its weight in S&P 500 names and LFSC has 0%, so LFSC differs more from the index.
Which is cheaper, GDOC or LFSC?
GDOC charges 0.75% a year and LFSC charges 0.54%, so LFSC is cheaper. Fees come from each fund's prospectus.
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ETFIQ, GDOC against LFSC, data as of Nov 4, 2026. https://etfiq.com/compare/themes/gdoc-vs-lfsc

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