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Data as of .

LFSC vs TMAT: which is really different?

LFSC and TMAT hold 1% of their weight in the same names, and LFSC returned more over the year.

F/m Emerald Life Sciences Innovation ETF and Main Thematic Innovation ETF.

0.0%LFSC in the S&P 500
46.4%TMAT in the S&P 500
+53.0%LFSC total return, 1 year
+3.5%TMAT total return, 1 year

ETFIQ Off-Index Score: LFSC scores higher

How much of it is not the index it is sold as an alternative to?

LFSC 91.8TMAT 24.90.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

LFSC100% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 55% of the fund · 39 holdings filed May 31, 2026 · Nasdaq-100: 1% in0%100%0% of its weight in S&P 500 companiesof its weight outside the S&P 500active share 100% · top ten 55% of the fund
TMAT54% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
46%54%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 92% · top ten 24% of the fund · 88 holdings filed Apr 30, 2026 · Nasdaq-100: 23% in46%54%in the S&P 500outside the S&P 500active share 92% · top ten 24% of the fund

1% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, LFSC and TMAT hold 1% of their money in the same securities at the same weight.

Positions LFSC and TMAT both hold, largest shared weight first
HoldingLFSCTMAT
Hinge Health Inc0.94%1.32%
Waystar Holding Corp1.04%0.36%
Only in each
Only in LFSCOnly in TMAT
Travere Therapeutics Inc 7.66%VICOR CORP 2.98%
Cogent Biosciences Inc 7.52%MICRON TECHNOLOGY INC 2.81%
LivaNova PLC 7.11%LUMENTUM HOLDINGS INC 2.75%
Spyre Therapeutics Inc 6.41%CIENA CORP 2.61%
Guardant Health Inc 5.51%PALO ALTO NETWORKS INC 2.55%
Mirum Pharmaceuticals Inc 4.92%CLEAR SECURE INC 2.48%
Corcept Therapeutics Inc 4.79%KEYSIGHT TECHNOLOGIES INC 2.26%
United Therapeutics Corp 4.15%MODINE MANUFACTURING COMPANY 1.94%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and May 31, 2026.

Performance, window by window

LFSC and TMAT over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
LFSCTMATLFSCTMATLFSCTMAT
3 months+8.7%−5.8%+6.5 pts−8.1 pts+11.2 pts−3.3 pts
6 months+36.0%+21.2%+17.9 pts+3.1 pts+11.7 pts−3.1 pts
1 year+53.0%+3.5%+36.5 pts−13.0 pts+31.3 pts−18.2 pts
3 yearsnot published+105.6%not published+27.2 ptsnot published+7.4 pts
Since launch+81.3%+16.5%+44.3 pts−105.8 pts+30.9 pts−120.4 pts
Open the live comparison on ETFIQ
LFSC and TMAT on the same fields, as of Sep 18, 2026. Source: ETFIQ.
LFSC
F/m Emerald Life Sciences Innovation ETF
Holds 39 stocks in broad innovation and megatrends, 0% of its weight in S&P 500 companies
TMAT
Main Thematic Innovation ETF
Holds 88 stocks in broad innovation and megatrends, 46% of its weight in S&P 500 companies
IssuerF/mMain
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 5000.0%46.4%
Active share vs the S&P 500100.0%91.5%
In the Nasdaq-1000.6%22.9%
Holdings3988
Top ten, share of the fund54.7%24.2%
Expense ratio0.54%0.82%
Fee for the differing part0.54%0.90%
Total return, 1 year+53.0%+3.5%
vs the S&P 500+36.5 pts−13.0 pts
vs the Nasdaq-100+31.3 pts−18.2 pts
Below its high−6.8%−9.0%
Net assets$105m$211m

LFSC in plain words

By weight, 0% of LFSC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 55% of the fund across 39 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +53.0% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 36.5 pts. It sits 6.8% below its all-time high of Aug 19, 2026.

TMAT in plain words

By weight, 46% of TMAT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 92%. The top ten holdings are 24% of the fund across 88 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +3.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 13.0 pts. It sits 9.0% below its all-time high of Jun 30, 2026.

Questions people ask

Do LFSC and TMAT hold the same stocks?
By their latest filings, 1% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, LFSC or TMAT?
LFSC has 0% of its weight in S&P 500 names and TMAT has 46%, so LFSC differs more from the index.
Which is cheaper, LFSC or TMAT?
LFSC charges 0.54% a year and TMAT charges 0.82%, so LFSC is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

LFSC against TMAT, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, LFSC against TMAT, data as of Sep 18, 2026. https://etfiq.com/compare/themes/lfsc-vs-tmat Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources