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Data as of .

FMED vs INVN: which is really different?

FMED and INVN hold 0% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Medicine ETF and Alger Russell Innovation ETF.

25.4%FMED in the S&P 500
32.5%INVN in the S&P 500
+28.3%FMED total return, 1 year
+20.7%INVN total return, 1 year

ETFIQ Off-Index Score: INVN scores higher

How much of it is not the index it is sold as an alternative to?

FMED 40.1INVN 55.90.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund
INVN68% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
33%68%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 23% of the fund · 50 holdings filed Jun 30, 2026 · Nasdaq-100: 10% in33%68%inoutside the S&P 500active share 99% · top ten 23% of the fund

0% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FMED and INVN hold 0% of their money in the same securities at the same weight.

Only in each
Only in FMEDOnly in INVN
UCB SA 4.75%ROBLOX CORP 2.56%
LIFESTANCE HEALTH GROUP INC 4.29%ZEBRA TECHNOLOGIES CORP 2.38%
DANAHER CORP 3.43%EXPEDIA GROUP INC 2.29%
10X GENOMICS INC 3.12%MAPLEBEAR INC 2.25%
INTUITIVE SURGICAL INC 2.93%BLOCK INC 2.23%
COGENT BIOSCIENCES INC 2.86%ZSCALER INC 2.21%
ALNYLAM PHARMACEUTICALS INC 2.80%BILL HOLDINGS INC 2.18%
ARGENX SE 2.79%BIOGEN INC 2.18%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.

Performance, window by window

FMED and INVN over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FMEDINVNFMEDINVNFMEDINVN
3 months+21.3%+24.7%+19.0 pts+22.4 pts+23.7 pts+27.2 pts
6 months+32.3%+37.7%+14.3 pts+19.6 pts+8.0 pts+13.4 pts
1 year+28.3%+20.7%+11.7 pts+4.2 pts+6.5 pts−1.1 pts
3 years+39.6%not published−38.8 ptsnot published−58.5 ptsnot published
Since launch+25.8%+29.2%−57.6 pts−2.8 pts−78.1 pts−11.9 pts
Open the live comparison on ETFIQ
FMED and INVN on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
INVN
Alger Russell Innovation ETF
Holds 50 stocks in broad innovation and megatrends, 32% of its weight in S&P 500 companies
IssuerFidelityAlger
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50025.4%32.5%
Active share vs the S&P 50097.1%98.5%
In the Nasdaq-1008.7%9.8%
Holdings6850
Top ten, share of the fund31.5%22.6%
Expense ratio0.50%0.55%
Fee for the differing part0.51%0.56%
Total return, 1 year+28.3%+20.7%
vs the S&P 500+11.7 pts+4.2 pts
vs the Nasdaq-100+6.5 pts−1.1 pts
Below its high−3.8%−5.6%
Net assets$52m$10m

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

INVN in plain words

By weight, 32% of INVN's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 23% of the fund across 50 positions, as filed for Jun 30, 2026. Over the year to Sep 18, 2026 the fund returned +20.7% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 4.2 pts. It sits 5.6% below its all-time high of Sep 3, 2026.

Questions people ask

Do FMED and INVN hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or INVN?
FMED has 25% of its weight in S&P 500 names and INVN has 32%, so INVN differs more from the index.
Which is cheaper, FMED or INVN?
FMED charges 0.50% a year and INVN charges 0.55%, so FMED is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FMED against INVN, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FMED against INVN, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fmed-vs-invn Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources