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Data as of .

FDFF vs FMED: which is really different?

FDFF and FMED hold 0% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Finance ETF and Fidelity Disruptive Medicine ETF.

45.1%FDFF in the S&P 500
25.4%FMED in the S&P 500
−4.9%FDFF total return, 1 year
+28.3%FMED total return, 1 year

ETFIQ Off-Index Score: FDFF scores higher

How much of it is not the index it is sold as an alternative to?

FDFF 42.3FMED 40.10.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FDFF55% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
45%55%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 97% · top ten 48% of the fund · 45 holdings filed May 31, 2026 · Nasdaq-100: 2% in45%55%in the S&P 500outside the S&P 500active share 97% · top ten 48% of the fund
FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund

0% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FDFF and FMED hold 0% of their money in the same securities at the same weight.

Only in each
Only in FDFFOnly in FMED
BLACKROCK INC 6.00%UCB SA 4.75%
DBS GROUP HOLDINGS LTD 5.82%LIFESTANCE HEALTH GROUP INC 4.29%
CAPITAL ONE FINANCIAL CORP 5.43%DANAHER CORP 3.43%
BANKINTER SA 4.91%10X GENOMICS INC 3.12%
FINECOBANK SPA 4.52%INTUITIVE SURGICAL INC 2.93%
APOLLO GLOBAL MANAGEMENT, INC 4.47%COGENT BIOSCIENCES INC 2.86%
VISA INC 4.33%ALNYLAM PHARMACEUTICALS INC 2.80%
BLOCK INC 4.17%ARGENX SE 2.79%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated May 31, 2026.

Performance, window by window

FDFF and FMED over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FDFFFMEDFDFFFMEDFDFFFMED
3 months+8.2%+21.3%+5.9 pts+19.0 pts+10.6 pts+23.7 pts
6 months+16.3%+32.3%−1.8 pts+14.3 pts−8.0 pts+8.0 pts
1 year−4.9%+28.3%−21.5 pts+11.7 pts−26.7 pts+6.5 pts
3 years+41.4%+39.6%−37.0 pts−38.8 pts−56.7 pts−58.5 pts
Since launch+45.6%+25.8%−37.8 pts−57.6 pts−58.3 pts−78.1 pts
Open the live comparison on ETFIQ
FDFF and FMED on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FDFF
Fidelity Disruptive Finance ETF
Holds 45 stocks in broad innovation and megatrends, 45% of its weight in S&P 500 companies
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
IssuerFidelityFidelity
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50045.1%25.4%
Active share vs the S&P 50097.4%97.1%
In the Nasdaq-1002.4%8.7%
Holdings4568
Top ten, share of the fund47.5%31.5%
Expense ratio0.50%0.50%
Fee for the differing part0.51%0.51%
Total return, 1 year−4.9%+28.3%
vs the S&P 500−21.5 pts+11.7 pts
vs the Nasdaq-100−26.7 pts+6.5 pts
Below its high−8.3%−3.8%
Net assets$47m$52m

FDFF in plain words

By weight, 45% of FDFF's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 48% of the fund across 45 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned −4.9% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 21.5 pts. It sits 8.3% below its all-time high of Jan 30, 2025.

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

Questions people ask

Do FDFF and FMED hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FDFF or FMED?
FDFF has 45% of its weight in S&P 500 names and FMED has 25%, so FDFF differs more from the index.
Which is cheaper, FDFF or FMED?
FDFF charges 0.50% a year and FMED charges 0.50%, so FDFF is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FDFF against FMED, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FDFF against FMED, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fdff-vs-fmed Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources