Data as of Oct 28, 2026.

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VT vs XBI: Differences, Returns & Fees

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Over the year to Oct 28, 2026, VT returned +13.5% to XBI's +41.2%, and VT charges 0.06% to XBI's 0.35%.

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Net assets: $81.8bn on Sep 30, 2026 for Vanguard Total World Stock Index ETF, and $10.3bn on Oct 27, 2026 for State Street SPDR S&P Biotech ETF.

At a glance
+13.5%
VT total return, 1 year
+41.2%
XBI total return, 1 year
0.06%
VT expense ratio
0.35%
XBI expense ratio

Pair scorecard

VT costs 0.29 points a year less; their one-year returns differ by 27.7 points; VT is 7.9 times larger.

VT vs XBI: Differences, Returns & Fees
MeasureVTXBI
Return
Total return, 1 year+13.5%+41.2%
Drawdown
Below its all-time high8.9%, high on Feb 8, 2021
Benchmark
What it tracksFTSE Global All Cap IndexBiotech
Cost and size
Expense ratio0.06%0.35%
Net assets, as of Sep 30, 2026$81.8bn$10.4bn
Active share vs the S&P 50098%
Holdings
Holdings in common1%
Top ten holdings, share of the fund22.5%18%

Holdings in common uses holdings dated Sep 30, 2026 and Oct 27, 2026. Method

Risk and return

Jul 3, 2008 to Oct 23, 2026 · 955 weekly returns
VT XBI
Return
Total return edge XBI +371.6% +695.8%
Annualized edge XBI +8.8% +12.0%
Price return edge XBI +221.4% +663.3%
Risk
Volatility edge VT 18.3% 30.2%
Max drawdown edge VT −48.3% −61.5%
Risk-adjusted
Sharpe edge Tie 0.48 0.48
Sortino edge XBI (slight) 0.66 0.70
Calmar edge XBI (slight) 0.18 0.19
Reading

XBI returned more: +695.8% to +371.6%. VT swung less: 18.3% to 30.2%. VT fell less at its worst: −48.3% to −61.5%.

Full scorecard

9 measures, with how each is measured
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Risk and return: VT vs XBI: Differences, Returns & Fees
MeasureVTXBIEdgeHow it is measured
Return
Total return+371.6%+695.8%XBIPrice change plus distributions, reinvested.
Annualized+8.8%+12.0%XBITotal return as a yearly rate.
Price return+221.4%+663.3%XBIPrice change alone, distributions left out.
Risk
Volatility18.3%30.2%VTSpread of weekly returns, annualized. Lower is steadier.
Downside deviation13.1%20.5%VTLike volatility, counting only weeks below the Treasury bill rate.
Max drawdown−48.3%−61.5%VTDeepest fall from a high to the low after it.
Risk-adjusted
Sharpe0.480.48TieReturn above Treasury bills per unit of volatility.
Sortino0.660.70XBI (slight)Return above Treasury bills per unit of downside deviation.
Calmar0.180.19XBI (slight)Annualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 955 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

1%

By the books each fund has filed, VT and XBI hold 1% of their money in the same securities at the same weight. Holdings dated Sep 30, 2026 and Oct 27, 2026.

0 half 100%

half

1% in common

Positions both hold · largest shared weight first VT XBI
AbbVie Inc 0.40% 1.67%
Amgen Inc 0.19% 1.68%
Gilead Sciences Inc 0.16% 1.60%
Vertex Pharmaceuticals Inc 0.11% 1.46%
Regeneron Pharmaceuticals Inc 0.06% 1.48%
Moderna Inc 0.06% 2.24%
Natera Inc 0.05% 1.82%
Revolution Medicines Inc 0.03% 1.31%
Biogen Inc 0.03% 1.75%
Alnylam Pharmaceuticals Inc 0.03% 1.29%
Insmed Inc 0.02% 1.08%
United Therapeutics Corp 0.02% 1.71%
Only in one fund ↓
Only in VT
NVIDIA Corp 4.54%
Apple Inc 4.11%
Microsoft Corp 3.25%
Amazon.com Inc 2.06%
Alphabet Inc 1.73%
Taiwan Semiconductor Manufacturing Co Ltd 1.62%
Broadcom Inc 1.39%
Meta Platforms Inc 1.36%
Only in XBI
IOVANCE BIOTHERAPEUTICS INC 1.62%
GRAIL INC 1.46%
KODIAK SCIENCES INC 1.16%
ARCUTIS BIOTHERAPEUTICS INC 0.95%
CAREDX INC 0.92%
RELAY THERAPEUTICS INC 0.91%
DYNE THERAPEUTICS INC 0.73%
SELLAS LIFE SCIENCES GROUP I 0.68%
Check overlap with more funds →

Side by side

VT Vanguard Total World Stock Index ETF XBI State Street SPDR S&P Biotech ETF
Where it sits Stock ETF Thematic ETF
What it is Tracks an index of Total World Stock Biotech
Total return, 1 year +13.5% +41.2%
Expense ratio 0.06% 0.35%
Already in the S&P 500 54.7% 13.2%
Holdings 10194 165
Net assets, VT as of Sep 30, 2026 and XBI as of Oct 27, 2026 $81.8bn $10.3bn

VT and XBI on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Client brief · page 1 of 2 Report BR-C1B0C9466F

VT and XBI do different jobs. What does each one do in a portfolio?

  1. What each follows. VT follows FTSE Global All Cap Index and XBI follows Biotech.
  2. Holdings in common. 1% of the weight is in the same securities (holdings dated Sep 30, 2026 and Oct 27, 2026).
  3. One-year total return. Over 1 year to Oct 28, 2026 VT returned +13.5% and XBI +41.2% with distributions reinvested, a gap of 27.7 points.

Data as of Oct 28, 2026.

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About each fund
VT

VT tracks an index of Total World Stock. Over the year to Oct 28, 2026 it returned +13.5% with distributions reinvested. The prospectus expense ratio is 0.06% a year. By its holdings published by its issuer as of Sep 30, 2026, 55% of the fund by weight is stocks the S&P 500 also holds, across 10,194 positions, with the top ten at 22.5%.

XBI

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.

Questions people ask

Are VT and XBI in the same category?
VT is a stock ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, VT or XBI?
In the year to Oct 28, 2026, with distributions reinvested, VT returned +13.5% and XBI +41.2%.
Which is cheaper, VT or XBI?
VT is cheaper, by 0.29 percentage points a year. That is about $29 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do VT and XBI overlap with the S&P 500?
By their latest filed holdings, 55% of VT and 13% of XBI by weight is stocks the S&P 500 already holds.
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ETFIQ, VT against XBI, data as of Oct 28, 2026. https://etfiq.com/compare/any/vt-vs-xbi

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.