Data as of Oct 28, 2026.

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IBB vs QQQ: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to QQQ's +15.2%, and QQQ charges 0.18% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $11.0bn for iShares Biotechnology ETF and $483.0bn for Invesco QQQ Trust, Series 1.

At a glance
+37.5%
IBB total return, 1 year
+15.2%
QQQ total return, 1 year
0.44%
IBB expense ratio
0.18%
QQQ expense ratio

Pair scorecard

QQQ costs 0.26 points a year less; their one-year returns differ by 22.3 points; QQQ is far larger, $483.0bn against $11.0bn.

IBB vs QQQ: Differences, Returns & Fees
MeasureIBBQQQ
Return
Total return, 1 year+37.5%+15.2%
Drawdown
Below its high4.5%, high on Oct 6, 2026
Benchmark
What it tracksBiotechNasdaq-100 Index
Cost and size
Expense ratio0.44%0.18%
Net assets, as of Oct 27, 2026$11.0bn$483.0bn
Active share vs the S&P 50099%
Holdings
Holdings in common3%
Top ten holdings, share of the fund50%46.7%

Holdings in common uses holdings dated Oct 27, 2026. Method

Risk and return

Feb 23, 2001 to Oct 23, 2026 · 1,339 weekly returns
IBB QQQ
Return
Total return edge QQQ +586.4% +1,532.9%
Annualized edge QQQ +7.8% +11.5%
Price return edge QQQ +557.1% +1,276.3%
Risk
Volatility edge QQQ (slight) 24.3% 22.2%
Max drawdown edge Tie −59.2% −60.2%
Risk-adjusted
Sharpe edge QQQ 0.36 0.52
Sortino edge QQQ 0.50 0.75
Calmar edge QQQ 0.13 0.19
Reading

QQQ returned more: +1,532.9% to +586.4%. QQQ swung slightly less: 22.2% to 24.3%. IBB and QQQ fell about the same at their worst: −59.2% and −60.2%.

Full scorecard

9 measures, with how each is measured
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Risk and return: IBB vs QQQ: Differences, Returns & Fees
MeasureIBBQQQEdgeHow it is measured
Return
Total return+586.4%+1,532.9%QQQPrice change plus distributions, reinvested.
Annualized+7.8%+11.5%QQQTotal return as a yearly rate.
Price return+557.1%+1,276.3%QQQPrice change alone, distributions left out.
Risk
Volatility24.3%22.2%QQQ (slight)Spread of weekly returns, annualized. Lower is steadier.
Downside deviation17.2%15.4%QQQLike volatility, counting only weeks below the Treasury bill rate.
Max drawdown−59.2%−60.2%TieDeepest fall from a high to the low after it.
Risk-adjusted
Sharpe0.360.52QQQReturn above Treasury bills per unit of volatility.
Sortino0.500.75QQQReturn above Treasury bills per unit of downside deviation.
Calmar0.130.19QQQAnnualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 1,339 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

3%

By the books each fund has filed, IBB and QQQ hold 3% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

3% in common

Positions both hold · largest shared weight first IBB QQQ
AMGEN INC 8.20% 1.04%
GILEAD SCIENCES 8.56% 0.85%
VERTEX PHARMACEUTICALS 7.53% 0.57%
MODERNA 5.29% 0.36%
REGENERON PHARMACEUTICALS 5.64% 0.35%
ALNYLAM PHARMACEUTICALS 2.11% 0.13%
Only in one fund ↓
Only in IBB
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
BIOGEN 2.58%
REVOLUTION MEDICINES 2.50%
BEONE MEDICINES AG 2.15%
GENMAB SPONSORED ADR 1.72%
UNITED THERAPEUTICS 1.71%
Only in QQQ
NVIDIA Corp 8.17%
Apple Inc 7.88%
Microsoft Corp 6.14%
Micron Technology Inc 4.50%
Amazon.com Inc 4.25%
Advanced Micro Devices Inc 3.93%
Tesla Inc 3.33%
Alphabet Inc 2.92%
Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF QQQ Invesco QQQ Trust, Series 1
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks the Nasdaq-100
Total return, 1 year +37.5% +15.2%
Its benchmark over the same days not measured +15.2% (QQQM)
Gap to its benchmark not measured 0.0 pts vs QQQM
Expense ratio 0.44% 0.18%
Already in the S&P 500 40.2% 95.7%
Holdings 245 103
Net assets, as of Oct 27, 2026 $11.0bn $483.0bn

IBB and QQQ on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Client brief · page 1 of 2 Report BR-0142EC1B43

IBB and QQQ do different jobs. What does each one do in a portfolio?

  1. What each follows. IBB follows Biotech and QQQ follows Nasdaq-100 Index.
  2. Holdings in common. 3% of the weight is in the same securities (holdings dated Oct 27, 2026).
  3. One-year total return. Over 1 year to Oct 28, 2026 IBB returned +37.5% and QQQ +15.2% with distributions reinvested, a gap of 22.3 points.

Data as of Oct 28, 2026.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

QQQ

QQQ tracks the Nasdaq-100. Over the year to Oct 28, 2026 it returned +15.2% with distributions reinvested, against +15.2% for its benchmark, the Nasdaq-100 Index. The prospectus expense ratio is 0.18% a year. By its holdings published by its issuer for Oct 27, 2026, 96% of the fund by weight is stocks the S&P 500 also holds, across 103 positions, with the top ten at 46.7%. It sat 4.5% below its high of Oct 6, 2026 on Oct 28, 2026.

Questions people ask

Are IBB and QQQ in the same category?
IBB is a thematic ETF and QQQ is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or QQQ?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and QQQ +15.2%.
Which is cheaper, IBB or QQQ?
QQQ is cheaper, by 0.26 percentage points a year. That is about $26 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and QQQ overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 96% of QQQ by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, IBB against QQQ, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-qqq

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.