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Data as of Oct 28, 2026.

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DFUS vs XBI: Differences, Returns & Fees

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Over the year to Oct 28, 2026, DFUS returned +13.8% to XBI's +41.2%, and DFUS charges 0.09% to XBI's 0.35%.

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Net assets: $20.9bn on Jul 31, 2026 for Dimensional U.S. Equity Market ETF, and $10.3bn on Oct 27, 2026 for State Street SPDR S&P Biotech ETF.

DFUS on its own →XBI on its own →
At a glance
+13.8%
DFUS total return, 1 year
+41.2%
XBI total return, 1 year
0.09%
DFUS expense ratio
0.35%
XBI expense ratio

Pair scorecard

DFUS costs 0.26 points a year less; their one-year returns differ by 27.4 points.

DFUS vs XBI: Differences, Returns & Fees
MeasureDFUSXBI
Return
Total return, 1 year+13.8%+41.2%
Drawdown
Below its all-time high8.9%, high on Feb 8, 2021
Benchmark
What it tracksNo index, actively managedBiotech
Cost and size
Expense ratio0.09%0.35%
Net assets, DFUS as of Jul 31, 2026 and XBI as of Oct 27, 2026$20.9bn$10.3bn
Active share vs the S&P 50098%
Holdings
Holdings in common2%
Top ten holdings, share of the fund34.6%18%

Holdings in common uses holdings dated Jul 31, 2026 and Oct 27, 2026. Method

What they share

2%

By the books each fund has filed, DFUS and XBI hold 2% of their money in the same securities at the same weight. Holdings dated Jul 31, 2026 and Oct 27, 2026.

0 half 100%

half

2% in common

Positions both hold · largest shared weight first DFUS XBI
ABBVIE INC. 0.64% 1.67%
AMGEN INC. 0.30% 1.68%
GILEAD SCIENCES, INC. 0.24% 1.60%
VERTEX PHARMACEUTICALS INCORPORATED 0.18% 1.46%
REGENERON PHARMACEUTICALS, INC. 0.11% 1.48%
NATERA, INC. 0.05% 1.82%
REVOLUTION MEDICINES, INC. 0.05% 1.31%
BIOGEN INC. 0.04% 1.75%
ALNYLAM PHARMACEUTICALS, INC. 0.04% 1.29%
INSMED INCORPORATED 0.03% 1.08%
INCYTE CORPORATION 0.03% 1.35%
UNITED THERAPEUTICS CORPORATION 0.03% 1.71%
Only in one fund ↓
Only in DFUS
NVIDIA CORPORATION 6.75%
APPLE INC. 6.45%
MICROSOFT CORPORATION 4.99%
AMAZON.COM, INC. 3.83%
ALPHABET INC. 3.00%
BROADCOM INC. 2.63%
ALPHABET INC. 2.48%
META PLATFORMS, INC. 1.77%
Only in XBI
TWIST BIOSCIENCE CORP 1.86%
SPYRE THERAPEUTICS INC 1.67%
ALKERMES PLC 1.43%
PROTAGONIST THERAPEUTICS INC 1.42%
CRISPR THERAPEUTICS AG 1.38%
COGENT BIOSCIENCES INC 1.24%
CYTOKINETICS INC 1.22%
PRAXIS PRECISION MEDICINES I 1.13%
Check overlap with more funds →

Side by side

DFUS Dimensional U.S. Equity Market ETF XBI State Street SPDR S&P Biotech ETF
Where it sits Stock ETF Thematic ETF
Issuer Dimensional State Street
What it is Actively managed Biotech
Total return, 1 year +13.8% +41.2%
Its benchmark over the same days +13.3% (IWV) not measured
Gap to its benchmark +0.5 pts vs IWV not measured
Expense ratio 0.09% 0.35%
Already in the S&P 500 89.4% 13.2%
Holdings 2236 165
Net assets, DFUS as of Jul 31, 2026 and XBI as of Oct 27, 2026 $20.9bn $10.3bn

DFUS and XBI on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
DFUS

Over the year to Oct 28, 2026 it returned +13.8% with distributions reinvested, against +13.3% for its benchmark, the Russell 3000 Index.

DFUS is actively managed and tracks no index. The prospectus expense ratio is 0.09% a year. By its holdings filed for Jul 31, 2026, 89% of the fund by weight is stocks the S&P 500 also holds, across 2,236 positions, with the top ten at 34.6%.

XBI

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 18% of the fund across 165 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +41.2% with distributions reinvested. It sits 8.9% below its all-time high of Feb 8, 2021.

Questions people ask

Are DFUS and XBI in the same category?
DFUS is a stock ETF and XBI is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, DFUS or XBI?
In the year to Oct 28, 2026, with distributions reinvested, DFUS returned +13.8% and XBI +41.2%.
Which is cheaper, DFUS or XBI?
DFUS is cheaper, by 0.26 percentage points a year. That is about $26 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do DFUS and XBI overlap with the S&P 500?
By their latest filed holdings, 89% of DFUS and 13% of XBI by weight is stocks the S&P 500 already holds.
Other comparisons
DFUS vs IBBDFUS vs GDXDFUS vs REMXDFUS vs LYTESCHB vs XBIQUAL vs XBIIWB vs XBIGRNY vs XBI
Where to next
DFUS on its own →XBI on its own →Hold both: look the portfolio through →Rankings →DFUS dividend history →DFUS holdings →XBI dividend history →XBI holdings →Standards and sources →
Sources and dates
DFUS filings on SEC EDGAR ↗
DFUS prospectus with the expense ratio (SEC) ↗
Dimensional website ↗
XBI filings on SEC EDGAR ↗
XBI prospectus with the expense ratio (SEC) ↗
State Street website ↗

Links are sources, not endorsements. A comparison is not a recommendation.

How this is computed

Overlap adds up the smaller of the two weights for each security both funds hold.

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ETFIQ, DFUS against XBI, data as of Oct 28, 2026. https://etfiq.com/compare/any/dfus-vs-xbi

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.