Data as of Nov 4, 2026.

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Thematic ETFs

FMED vs TNXT: Holdings Overlap & Returns

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FMED and TNXT hold 10% of their weight in the same names.

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Net assets: $52m on Sep 30, 2026 for Fidelity Disruptive Medicine ETF, and $19m on Nov 3, 2026 for T. Rowe Price Innovation Leaders ETF.

At a glance
21.8%
FMED in the S&P 500
64.2%
TNXT in the S&P 500
+27.4%
FMED total return, 1 year
+13.4%
TNXT total return, since launch, Jan 29, 2026
FMED · 1 year to Nov 4, 2026 78% of its weight is outside the S&P 500
78% of its weight is outside the S&P 50022% of FMED's weight is in S&P 500 companies and 78% is outside the index. Holdings as of Aug 31, 2026.22%78%in the S&P 500of its weight outside the S&P 500active share 98% · top ten 33% of the fund · 72 holdings as filed for Aug 31, 2026 · Nasdaq-100: 5% in78% of its weight is outside the S&P 50022% of FMED's weight is in S&P 500 companies and 78% is outside the index. Holdings as of Aug 31, 2026.22%78%inoutside the S&P 500active share 98% · Nasdaq-100: 5% in

22% of FMED's weight is in S&P 500 companies and 78% is outside the index. Holdings as of Aug 31, 2026.

TNXT · 6 months to Nov 4, 2026 36% of its weight is outside the S&P 500
36% of its weight is outside the S&P 50064% of TNXT's weight is in S&P 500 companies and 36% is outside the index. Holdings as of Jun 30, 2026.64%36%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 52% · top ten 32% of the fund · 272 holdings as filed for Jun 30, 2026 · Nasdaq-100: 47% in36% of its weight is outside the S&P 50064% of TNXT's weight is in S&P 500 companies and 36% is outside the index. Holdings as of Jun 30, 2026.64%36%in the S&P 500outsideactive share 52% · Nasdaq-100: 47% in

64% of TNXT's weight is in S&P 500 companies and 36% is outside the index. Holdings as of Jun 30, 2026.

Pair scorecard

TNXT costs 0.01 points a year less.

FMED vs TNXT: Holdings Overlap & Returns
MeasureFMEDTNXT
Return
Total return, 1 year+27.4%not published
Benchmark
What it tracksBroad innovation and megatrendsBroad innovation and megatrends
Cost and size
Expense ratio0.50%0.49%
Net assets, FMED as of Sep 30, 2026 and TNXT as of Nov 3, 2026$52m$19m
Holdings
Holdings in common10%

Method

Risk and return

Feb 6, 2026 to Oct 30, 2026 · 38 weekly returns
FMED TNXT
Return
Total return edge FMED +25.7% +15.6%
Price return edge FMED +25.7% +15.6%
Risk
Max drawdown edge TNXT (slight) −9.8% −9.5%
Reading

From Feb 2026 to Oct 2026, FMED returned more: +25.7% to +15.6%. TNXT fell slightly less at its worst: −9.5% to −9.8%.

Full scorecard

3 measures, with how each is measured
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Risk and return: FMED vs TNXT: Holdings Overlap & Returns
MeasureFMEDTNXTEdgeHow it is measured
Return
Total return+25.7%+15.6%FMEDPrice change plus distributions, reinvested.
Price return+25.7%+15.6%FMEDPrice change alone, distributions left out.
Risk
Max drawdown−9.8%−9.5%TNXT (slight)Deepest fall from a high to the low after it.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 38 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

10%

By the books each fund has filed, FMED and TNXT hold 10% of their money in the same securities at the same weight. Holdings dated Jun 30, 2026 and Aug 31, 2026.

0 half 100%

half

10% in common

Positions both hold · largest shared weight first FMED TNXT
UNITEDHEALTH GROUP INC 1.59% 0.97%
ELI LILLY and CO 0.89% 1.99%
GUARDANT HEALTH INC 1.53% 0.70%
NATERA INC 3.30% 0.67%
KYMERA THERAPEUTICS INC 1.96% 0.59%
BRIGHTSPRING HEALTH SERVICES INC 1.45% 0.48%
ARGENX SE 3.20% 0.46%
THERMO FISHER SCIENTIFIC INC 3.83% 0.39%
ROIVANT SCIENCES LTD 1.09% 0.34%
SPYRE THERAPEUTICS INC 0.45% 0.33%
INTUITIVE SURGICAL INC 2.05% 0.27%
MODERNA INC 2.72% 0.27%
Only in one fund ↓
Only in FMED
10X GENOMICS INC 5.19%
LIFESTANCE HEALTH GROUP INC 3.00%
ILLUMINA INC 2.82%
HEARTFLOW INC 2.59%
SARTORIUS STEDIM BIOTECH 2.56%
COGENT BIOSCIENCES INC 2.31%
KINIKSA PHARMACEUTICALS INTERNATIONAL PLC 1.83%
EDWARDS LIFESCIENCES CORP 1.76%
Only in TNXT
NVIDIA CORP 7.22%
APPLE INC 4.60%
AMAZON.COM INC 3.02%
BROADCOM INC 2.75%
MICROSOFT CORP 2.67%
ALPHABET INC CL A 2.57%
ADVANCED MICRO DEVICES 2.53%
ALPHABET INC CL C 2.28%
Check overlap with more funds →

Window by window

Window by window: FMED vs TNXT: Holdings Overlap & Returns
Total return
WindowFMEDTNXT
3 months+14.9%−0.2%
6 months+31.2%+6.6%
1 year+27.4%–
3 years+57.8%–
Since launchNot the same days: FMED Jun 2023 · TNXT Jan 2026+31.7%+13.4%

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Side by side

FMED Fidelity Disruptive Medicine ETF · Holds 72 stocks in broad innovation and megatrends, 22% of its weight in S&P 500 companies TNXT T. Rowe Price Innovation Leaders ETF · Holds 272 stocks in broad innovation and megatrends, 64% of its weight in S&P 500 companies
Theme Broad innovation and megatrends Broad innovation and megatrends
In the S&P 500 21.8% 64.2%
Active share vs the S&P 500 97.5% 51.6%
In the Nasdaq-100 5.1% 47.1%
Holdings 72 272
Top ten, share of the fund 33.2% 31.8%
Expense ratio 0.50% 0.49%
Fee for the differing part 0.51% 0.95%
Total return, 1 year +27.4% +13.4% (since launch, Jan 29, 2026)
vs its benchmark not measured not measured
Below its high −0.9% −3.8%
Net assets, FMED as of Sep 30, 2026 and TNXT as of Nov 3, 2026 $52m $19m

As of Nov 4, 2026. Source: ETFIQ.

10% of the two portfolios are the same securities at the same weight.

Client brief

No client brief for this pair: ETFIQ prints no one-year total return for TNXT.

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About each fund
FMED

By weight, 22% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 33% of the fund across 72 positions, as filed for Aug 31, 2026. Over the year to Nov 4, 2026 the fund returned +27.4% with distributions reinvested.

TNXT

By weight, 64% of TNXT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 52%. The top ten holdings are 32% of the fund across 272 positions, as filed for Jun 30, 2026. Since it first traded on Jan 29, 2026 the fund returned +13.4% with distributions reinvested.

Questions people ask

Do FMED and TNXT hold the same stocks?
By their latest filings, 10% of their books are the same securities at the same weight. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or TNXT?
FMED has 22% of its weight in S&P 500 names and TNXT has 64%, so FMED differs more from the index.
Which is cheaper, FMED or TNXT?
FMED charges 0.50% a year and TNXT charges 0.49%, so TNXT is cheaper. Fees come from each fund's prospectus.
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ETFIQ, FMED against TNXT, data as of Nov 4, 2026. https://etfiq.com/compare/themes/fmed-vs-tnxt

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