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Data as of .

FMED vs TMAT: which is really different?

FMED and TMAT hold 4% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Medicine ETF and Main Thematic Innovation ETF.

25.4%FMED in the S&P 500
46.4%TMAT in the S&P 500
+28.3%FMED total return, 1 year
+3.5%TMAT total return, 1 year

ETFIQ Off-Index Score: FMED scores higher

How much of it is not the index it is sold as an alternative to?

FMED 40.1TMAT 24.90.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund
TMAT54% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
46%54%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 92% · top ten 24% of the fund · 88 holdings filed Apr 30, 2026 · Nasdaq-100: 23% in46%54%in the S&P 500outside the S&P 500active share 92% · top ten 24% of the fund

4% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FMED and TMAT hold 4% of their money in the same securities at the same weight.

Positions FMED and TMAT both hold, largest shared weight first
HoldingFMEDTMAT
INSULET CORP1.10%1.18%
VERACYTE INC1.54%0.98%
VEEVA SYS INC1.79%0.71%
DEXCOM INC1.18%0.50%
WAYSTAR HOLDING CORP0.98%0.36%
INTUITIVE SURGICAL INC2.93%0.35%
Only in each
Only in FMEDOnly in TMAT
UCB SA 4.75%VICOR CORP 2.98%
LIFESTANCE HEALTH GROUP INC 4.29%MICRON TECHNOLOGY INC 2.81%
DANAHER CORP 3.43%LUMENTUM HOLDINGS INC 2.75%
10X GENOMICS INC 3.12%CIENA CORP 2.61%
COGENT BIOSCIENCES INC 2.86%PALO ALTO NETWORKS INC 2.55%
ALNYLAM PHARMACEUTICALS INC 2.80%CLEAR SECURE INC 2.48%
ARGENX SE 2.79%KEYSIGHT TECHNOLOGIES INC 2.26%
LEGEND BIOTECH CORP 2.30%MODINE MANUFACTURING COMPANY 1.94%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and May 31, 2026.

Performance, window by window

FMED and TMAT over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FMEDTMATFMEDTMATFMEDTMAT
3 months+21.3%−5.8%+19.0 pts−8.1 pts+23.7 pts−3.3 pts
6 months+32.3%+21.2%+14.3 pts+3.1 pts+8.0 pts−3.1 pts
1 year+28.3%+3.5%+11.7 pts−13.0 pts+6.5 pts−18.2 pts
3 years+39.6%+105.6%−38.8 pts+27.2 pts−58.5 pts+7.4 pts
Since launch+25.8%+16.5%−57.6 pts−105.8 pts−78.1 pts−120.4 pts
Open the live comparison on ETFIQ
FMED and TMAT on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
TMAT
Main Thematic Innovation ETF
Holds 88 stocks in broad innovation and megatrends, 46% of its weight in S&P 500 companies
IssuerFidelityMain
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50025.4%46.4%
Active share vs the S&P 50097.1%91.5%
In the Nasdaq-1008.7%22.9%
Holdings6888
Top ten, share of the fund31.5%24.2%
Expense ratio0.50%0.82%
Fee for the differing part0.51%0.90%
Total return, 1 year+28.3%+3.5%
vs the S&P 500+11.7 pts−13.0 pts
vs the Nasdaq-100+6.5 pts−18.2 pts
Below its high−3.8%−9.0%
Net assets$52m$211m

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

TMAT in plain words

By weight, 46% of TMAT's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 92%. The top ten holdings are 24% of the fund across 88 positions, as filed for Apr 30, 2026. Over the year to Sep 18, 2026 the fund returned +3.5% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 13.0 pts. It sits 9.0% below its all-time high of Jun 30, 2026.

Questions people ask

Do FMED and TMAT hold the same stocks?
By their latest filings, 4% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or TMAT?
FMED has 25% of its weight in S&P 500 names and TMAT has 46%, so FMED differs more from the index.
Which is cheaper, FMED or TMAT?
FMED charges 0.50% a year and TMAT charges 0.82%, so FMED is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FMED against TMAT, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FMED against TMAT, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fmed-vs-tmat Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources