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Data as of .

FMED vs ILDR: which is really different?

FMED and ILDR hold 5% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Medicine ETF and First Trust Innovation Leaders ETF.

25.4%FMED in the S&P 500
65.8%ILDR in the S&P 500
+28.3%FMED total return, 1 year
+19.9%ILDR total return, 1 year

ETFIQ Off-Index Score: FMED scores higher

How much of it is not the index it is sold as an alternative to?

FMED 40.1ILDR 2.90.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund
ILDR34% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
66%34%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 67% · top ten 44% of the fund · 82 holdings filed Sep 18, 2026 · Nasdaq-100: 49% in66%34%in the S&P 500outsideactive share 67% · top ten 44% of the fund

5% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FMED and ILDR hold 5% of their money in the same securities at the same weight.

Positions FMED and ILDR both hold, largest shared weight first
HoldingFMEDILDR
ASCENDIS PHARMA A/S2.12%0.93%
ARGENX SE2.79%0.91%
ALNYLAM PHARMACEUTICALS INC2.80%0.57%
MIRUM PHARMACEUTICALS INC0.54%0.90%
KYMERA THERAPEUTICS INC1.99%0.50%
VIRIDIAN THERAPEUTICS INC1.34%0.47%
Only in each
Only in FMEDOnly in ILDR
UCB SA 4.75%NVIDIA Corporation 9.78%
LIFESTANCE HEALTH GROUP INC 4.29%Advanced Micro Devices, Inc. 5.79%
DANAHER CORP 3.43%Amazon.com, Inc. 5.79%
10X GENOMICS INC 3.12%Alphabet Inc. (Class A) 4.81%
INTUITIVE SURGICAL INC 2.93%Broadcom Inc. 3.57%
COGENT BIOSCIENCES INC 2.86%Marvell Technology, Inc. 3.13%
LEGEND BIOTECH CORP 2.30%Eli Lilly and Company 3.02%
UNITEDHEALTH GROUP INC 2.26%Micron Technology, Inc. 2.80%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated May 31, 2026 and Sep 18, 2026.

Performance, window by window

FMED and ILDR over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FMEDILDRFMEDILDRFMEDILDR
3 months+21.3%+0.3%+19.0 pts−1.9 pts+23.7 pts+2.8 pts
6 months+32.3%+31.0%+14.3 pts+12.9 pts+8.0 pts+6.7 pts
1 year+28.3%+19.9%+11.7 pts+3.3 pts+6.5 pts−1.9 pts
3 years+39.6%+120.9%−38.8 pts+42.5 pts−58.5 pts+22.7 pts
Since launch+25.8%+92.7%−57.6 pts−3.0 pts−78.1 pts−30.0 pts
Open the live comparison on ETFIQ
FMED and ILDR on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
ILDR
First Trust Innovation Leaders ETF
Holds 82 stocks in broad innovation and megatrends, 66% of its weight in S&P 500 companies
IssuerFidelityFirst Trust
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50025.4%65.8%
Active share vs the S&P 50097.1%67.1%
In the Nasdaq-1008.7%49.0%
Holdings6882
Top ten, share of the fund31.5%44.1%
Expense ratio0.50%0.75%
Fee for the differing part0.51%1.12%
Total return, 1 year+28.3%+19.9%
vs the S&P 500+11.7 pts+3.3 pts
vs the Nasdaq-100+6.5 pts−1.9 pts
Below its high−3.8%−3.5%
Net assets$52m$342m

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

ILDR in plain words

By weight, 66% of ILDR's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 67%. The top ten holdings are 44% of the fund across 82 positions, as published by its issuer for Sep 18, 2026. Over the year to Sep 18, 2026 the fund returned +19.9% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 3.3 pts.

Questions people ask

Do FMED and ILDR hold the same stocks?
By their latest filings, 5% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or ILDR?
FMED has 25% of its weight in S&P 500 names and ILDR has 66%, so FMED differs more from the index.
Which is cheaper, FMED or ILDR?
FMED charges 0.50% a year and ILDR charges 0.75%, so FMED is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FMED against ILDR, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FMED against ILDR, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fmed-vs-ildr Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources