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Data as of .

FMED vs THMZ: which is really different?

FMED and THMZ hold 7% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Medicine ETF and Lazard Equity Megatrends ETF.

25.4%FMED in the S&P 500
55.2%THMZ in the S&P 500
+28.3%FMED total return, 1 year
+7.2%THMZ total return, 1 year

ETFIQ Off-Index Score: FMED scores higher

How much of it is not the index it is sold as an alternative to?

FMED 40.1THMZ 5.90.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund
THMZ45% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
55%45%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 73% · top ten 35% of the fund · 59 holdings filed Jun 30, 2026 · Nasdaq-100: 30% in55%45%in the S&P 500outsideactive share 73% · top ten 35% of the fund

7% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FMED and THMZ hold 7% of their money in the same securities at the same weight.

Positions FMED and THMZ both hold, largest shared weight first
HoldingFMEDTHMZ
DANAHER CORP3.43%1.93%
THERMO FISHER SCIENTIFIC INC1.54%1.94%
STRYKER CORP1.37%1.32%
ELI LILLY and CO1.07%1.79%
ARGENX SE2.79%0.73%
BOSTON SCIENTIFIC CORP1.44%0.46%
Only in each
Only in FMEDOnly in THMZ
UCB SA 4.75%Taiwan Semiconductor Manufacturing Co Lt 6.22%
LIFESTANCE HEALTH GROUP INC 4.29%Applied Materials Inc 5.68%
10X GENOMICS INC 3.12%Alphabet Inc 3.63%
INTUITIVE SURGICAL INC 2.93%Amazon.com Inc 3.58%
COGENT BIOSCIENCES INC 2.86%Microsoft Corp 2.84%
ALNYLAM PHARMACEUTICALS INC 2.80%NVIDIA Corp 2.83%
LEGEND BIOTECH CORP 2.30%Mitsubishi Electric Corp 2.79%
UNITEDHEALTH GROUP INC 2.26%Keysight Technologies Inc 2.66%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.

Performance, window by window

FMED and THMZ over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FMEDTHMZFMEDTHMZFMEDTHMZ
3 months+21.3%+0.3%+19.0 pts−1.9 pts+23.7 pts+2.8 pts
6 months+32.3%+17.1%+14.3 pts−1.0 pts+8.0 pts−7.2 pts
1 year+28.3%+7.2%+11.7 pts−9.4 pts+6.5 pts−14.6 pts
3 years+39.6%not published−38.8 ptsnot published−58.5 ptsnot published
Since launch+25.8%+37.0%−57.6 pts−16.5 pts−78.1 pts−34.3 pts
Open the live comparison on ETFIQ
FMED and THMZ on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
THMZ
Lazard Equity Megatrends ETF
Holds 59 stocks in broad innovation and megatrends, 55% of its weight in S&P 500 companies
IssuerFidelityLazard
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50025.4%55.2%
Active share vs the S&P 50097.1%73.1%
In the Nasdaq-1008.7%30.2%
Holdings6859
Top ten, share of the fund31.5%35.2%
Expense ratio0.50%0.50%
Fee for the differing part0.51%0.68%
Total return, 1 year+28.3%+7.2%
vs the S&P 500+11.7 pts−9.4 pts
vs the Nasdaq-100+6.5 pts−14.6 pts
Below its high−3.8%−3.5%
Net assets$52m$54m

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

THMZ in plain words

By weight, 55% of THMZ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 73%. The top ten holdings are 35% of the fund across 59 positions, as filed for Jun 30, 2026. Over the year to Sep 18, 2026 the fund returned +7.2% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 9.4 pts.

Questions people ask

Do FMED and THMZ hold the same stocks?
By their latest filings, 7% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or THMZ?
FMED has 25% of its weight in S&P 500 names and THMZ has 55%, so FMED differs more from the index.
Which is cheaper, FMED or THMZ?
FMED charges 0.50% a year and THMZ charges 0.50%, so FMED is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FMED against THMZ, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FMED against THMZ, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fmed-vs-thmz Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources