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Data as of .

FMED vs QQQJ: which is really different?

FMED and QQQJ hold 8% of their weight in the same names, and FMED returned more over the year.

Fidelity Disruptive Medicine ETF and Invesco NASDAQ Next Gen 100 ETF.

25.4%FMED in the S&P 500
46.2%QQQJ in the S&P 500
+28.3%FMED total return, 1 year
+22.4%QQQJ total return, 1 year

ETFIQ Off-Index Score: QQQJ scores higher

How much of it is not the index it is sold as an alternative to?

FMED 40.1QQQJ 56.60.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

FMED75% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
25%75%in the S&P 500of its weight outside the S&P 500active share 97% · top ten 32% of the fund · 68 holdings filed May 31, 2026 · Nasdaq-100: 9% in25%75%inoutside the S&P 500active share 97% · top ten 32% of the fund
QQQJ54% of its weight is outside the S&P 500 · 1 year to Sep 18, 2026
46%54%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 20% of the fund · 108 holdings filed Sep 19, 2026 · Nasdaq-100: 1% in46%54%in the S&P 500outside the S&P 500active share 99% · top ten 20% of the fund

8% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, FMED and QQQJ hold 8% of their money in the same securities at the same weight.

Positions FMED and QQQJ both hold, largest shared weight first
HoldingFMEDQQQJ
REVOLUTION MEDICINES INC1.74%2.05%
NATERA INC1.43%2.67%
ARGENX SE2.79%1.38%
GUARDANT HEALTH INC1.39%1.20%
ROIVANT SCIENCES LTD0.83%1.44%
ASCENDIS PHARMA A/S2.12%0.74%
INSULET CORP1.10%0.49%
Only in each
Only in FMEDOnly in QQQJ
UCB SA 4.75%eBay Inc 2.51%
LIFESTANCE HEALTH GROUP INC 4.29%Flex Ltd 2.01%
DANAHER CORP 3.43%NetApp Inc 1.97%
10X GENOMICS INC 3.12%Illumina Inc 1.83%
INTUITIVE SURGICAL INC 2.93%United Airlines Holdings Inc 1.78%
COGENT BIOSCIENCES INC 2.86%Elbit Systems Ltd 1.75%
ALNYLAM PHARMACEUTICALS INC 2.80%Steel Dynamics Inc 1.71%
LEGEND BIOTECH CORP 2.30%Kimberly-Clark Corp 1.66%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated May 31, 2026 and Sep 19, 2026.

Performance, window by window

FMED and QQQJ over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
FMEDQQQJFMEDQQQJFMEDQQQJ
3 months+21.3%−0.9%+19.0 pts−3.1 pts+23.7 pts+1.6 pts
6 months+32.3%+22.6%+14.3 pts+4.6 pts+8.0 pts−1.6 pts
1 year+28.3%+22.4%+11.7 pts+5.8 pts+6.5 pts+0.7 pts
3 years+39.6%+80.4%−38.8 pts+2.0 pts−58.5 pts−17.8 pts
Since launch+25.8%+72.2%−57.6 pts−63.7 pts−78.1 pts−81.2 pts
Open the live comparison on ETFIQ
FMED and QQQJ on the same fields, as of Sep 18, 2026. Source: ETFIQ.
FMED
Fidelity Disruptive Medicine ETF
Holds 68 stocks in broad innovation and megatrends, 25% of its weight in S&P 500 companies
QQQJ
Invesco NASDAQ Next Gen 100 ETF
Holds 108 stocks in broad innovation and megatrends, 46% of its weight in S&P 500 companies
IssuerFidelityInvesco
ThemeBroad innovation and megatrendsBroad innovation and megatrends
In the S&P 50025.4%46.2%
Active share vs the S&P 50097.1%98.6%
In the Nasdaq-1008.7%1.4%
Holdings68108
Top ten, share of the fund31.5%19.9%
Expense ratio0.50%0.15%
Fee for the differing part0.51%0.15%
Total return, 1 year+28.3%+22.4%
vs the S&P 500+11.7 pts+5.8 pts
vs the Nasdaq-100+6.5 pts+0.7 pts
Below its high−3.8%−5.5%
Net assets$52m$1.2bn

FMED in plain words

By weight, 25% of FMED's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 97%. The top ten holdings are 32% of the fund across 68 positions, as filed for May 31, 2026. Over the year to Sep 18, 2026 the fund returned +28.3% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 11.7 pts.

QQQJ in plain words

By weight, 46% of QQQJ's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 20% of the fund across 108 positions, as published by its issuer for Sep 19, 2026. Over the year to Sep 18, 2026 the fund returned +22.4% with distributions reinvested against +16.6% for the S&P 500, so a holder was ahead by 5.8 pts. It sits 5.5% below its all-time high of Aug 13, 2026.

Questions people ask

Do FMED and QQQJ hold the same stocks?
By their latest filings, 8% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, FMED or QQQJ?
FMED has 25% of its weight in S&P 500 names and QQQJ has 46%, so QQQJ differs more from the index.
Which is cheaper, FMED or QQQJ?
FMED charges 0.50% a year and QQQJ charges 0.15%, so QQQJ is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

FMED against QQQJ, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, FMED against QQQJ, data as of Sep 18, 2026. https://etfiq.com/compare/themes/fmed-vs-qqqj Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources