Do CANC and IHI hold the same stocks?

By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, CANC or IHI?

CANC has 22% of its weight in S&P 500 names and IHI has 88%, so IHI differs more from the index.

Which is cheaper, CANC or IHI?

CANC charges 0.75% a year and IHI charges 0.37%, so IHI is cheaper. Fees come from each fund's prospectus.

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CANC vs IHI: which is really different?

CANC and IHI hold 0% of their weight in the same names, and CANC returned +46.5% over the year. Tema Oncology ETF and iShares U.S. Medical Devices ETF.

22.2%

CANC in the S&P 500

88.0%

IHI in the S&P 500

+46.5%

CANC total return, 1 year

−14.4%

IHI total return, 1 year

CANC · 1 year to Sep 30, 202678% of its weight is outside the S&P 500

22% of CANC's weight is in S&P 500 companies and 78% is outside the index

IHI · 1 year to Sep 30, 202612% of its weight is outside the S&P 500

88% of IHI's weight is in S&P 500 companies and 12% is outside the index

ETFIQ Off-Index Score · IHI scores higherHow much of it is not the index it is sold as an alternative to?

CANC 35.2

IHI 57.6

0.1, the lowest in this set92.0, the highest

A percentile among the 375 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, CANC and IHI hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 30, 2026.

50%

half

0% in common

Positions both hold, largest shared weight first

Holding CANC IHI

Only in CANC

REVOLUTION MEDICINES INC 5.52%

MERCK & CO INC 4.87%

COGENT BIOSCIENCES INC 4.75%

ELI LILLY & CO 4.58%

NOVARTIS AG 3.70%

BRISTOL-MYERS SQUIBB CO 3.47%

BEONE MEDICINES LTD 3.36%

IOVANCE BIOTHERAPEUTICS INC 3.34%

Only in IHI

ABBOTT LABORATORIES 17.77%

INTUITIVE SURGICAL 14.92%

MEDTRONIC PLC 11.47%

IDEXX LABORATORIES 4.58%

DEXCOM INC 4.55%

EDWARDS LIFESCIENCES 4.52%

STRYKER 4.51%

BECTON DICKINSON 4.49%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	CANC	IHI	CANC	IHI	CANC	IHI
3 months	+2.9%	+2.5%	+0.4 pts	0.0 pts	+0.8 pts	+0.4 pts
6 months	+13.2%	−4.0%	−3.8 pts	−20.9 pts	−13.7 pts	−30.8 pts
1 year	+46.5%	−14.4%	+30.8 pts	−30.2 pts	+22.7 pts	−38.2 pts
3 years	+87.6%	+6.9%	+2.6 pts	−78.0 pts	−22.4 pts	−103.0 pts
Since launch CANC Sep 2021 · IHI Jan 2010	−29.4%	+519.6%	−119.5 pts	−285.0 pts	−142.3 pts	−1217.9 pts

CANC and IHI over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

CANC

Tema Oncology ETF · Holds 58 stocks in therapeutics and medical devices, 22% of its weight in S&P 500 companies

IHI

iShares U.S. Medical Devices ETF · Holds 54 stocks in therapeutics and medical devices, 88% of its weight in S&P 500 companies

Issuer Tema iShares

Theme Therapeutics and medical devices Therapeutics and medical devices

In the S&P 500 22.2% 88.0%

Active share vs the S&P 500 95.6% 98.7%

In the Nasdaq-100 2.4% 28.2%

Holdings 58 54

Top ten, share of the fund 40.1% 75.7%

Expense ratio 0.75% 0.37%

Fee for the differing part 0.78% 0.37%

Total return, 1 year +46.5% −14.4%

vs the S&P 500 +30.8 pts −30.2 pts

vs the Nasdaq-100 +22.7 pts −38.2 pts

Below its high −49.8% −22.0%

Net assets $209m $3.4bn

CANC and IHI on the same fields, as of Sep 30, 2026. Source: ETFIQ.

CANC in plain words

By weight, 22% of CANC's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 40% of the fund across 58 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned +46.5% with distributions reinvested against +15.7% for the S&P 500, so a holder was ahead by 30.8 pts. It sits 49.8% below its all-time high of Oct 20, 2021.

IHI in plain words

By weight, 88% of IHI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 76% of the fund across 54 positions, as published by its issuer for Sep 30, 2026. Over the year to Sep 30, 2026 the fund returned −14.4% with distributions reinvested against +15.7% for the S&P 500, so a holder was behind by 30.2 pts. It sits 22.0% below its all-time high of Sep 8, 2021.

Questions people ask

Do CANC and IHI hold the same stocks?: By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, CANC or IHI?: CANC has 22% of its weight in S&P 500 names and IHI has 88%, so IHI differs more from the index.
Which is cheaper, CANC or IHI?: CANC charges 0.75% a year and IHI charges 0.37%, so IHI is cheaper. Fees come from each fund's prospectus.

Other comparisons

CANC vs IBRN CANC vs MDEV CANC vs PSIL IHI vs MDEV IHI vs PSIL IHI vs IBRN

CANC on its own →IHI on its own →How every figure is computed →Standards and sources →

Where these figures came from

CANC filings on SEC EDGAR ↗CANC prospectus with the expense ratio (SEC) ↗Tema page for CANC ↗IHI filings on SEC EDGAR ↗IHI prospectus with the expense ratio (SEC) ↗iShares page for IHI ↗

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement. A comparison is not a recommendation.

Cite this page

ETFIQ, CANC against IHI, data as of Sep 30, 2026. https://etfiq.com/compare/themes/canc-vs-ihi

Open data

Free to use with attribution. Every figure is calculated from a named public source; the method is at etfiq.com/methodology.