Data as of Oct 28, 2026.

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IBB vs USFR: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to USFR's +4.1%, and USFR charges 0.15% to IBB's 0.44%.

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Net assets: $11.0bn on Oct 27, 2026 for iShares Biotechnology ETF, and $17.0bn on May 31, 2026 for WisdomTree Floating Rate Treasury Fund.

At a glance
+37.5%
IBB total return, 1 year
+4.1%
USFR total return, 1 year
0.44%
IBB expense ratio
0.15%
USFR expense ratio

Pair scorecard

USFR costs 0.29 points a year less; their one-year returns differ by 33.4 points.

IBB vs USFR: Differences, Returns & Fees
MeasureIBBUSFR
Return
Total return, 1 year+37.5%+4.1%
Benchmark
What it tracksBiotechBloomberg U.S. Treasury Floating Rate Bond Index
Cost and size
Expense ratio0.44%0.15%
Net assets, IBB as of Oct 27, 2026 and USFR as of May 31, 2026$11.0bn$17.0bn
Active share vs the S&P 50099%
Holdings
Holdings in common0%
In the S&P 500, by weight40%
Top ten holdings, share of the fund50%

Holdings in common uses holdings dated May 31, 2026 and Oct 27, 2026. Method

What they share

0%

By the books each fund has filed, IBB and USFR hold 0% of their money in the same securities at the same weight. Holdings dated May 31, 2026 and Oct 27, 2026.

0 half 100%

half

0% in common

Positions both hold · largest shared weight first IBB USFR
Only in one fund ↓
Only in IBB
GILEAD SCIENCES 8.56%
AMGEN INC 8.20%
VERTEX PHARMACEUTICALS 7.53%
REGENERON PHARMACEUTICALS 5.64%
MODERNA 5.29%
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
Only in USFR
UNITED STATES OF AMERICA - BUREAU OF THE PUBLIC DEBT 27.95%
UNITED STATES OF AMERICA - BUREAU OF THE PUBLIC DEBT 27.93%
UNITED STATES OF AMERICA - BUREAU OF THE PUBLIC DEBT 27.91%
UNITED STATES OF AMERICA - BUREAU OF THE PUBLIC DEBT 15.90%
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Side by side

IBB iShares Biotechnology ETF USFR WisdomTree Floating Rate Treasury Fund
Where it sits Thematic ETF Bond ETF
What it is Biotech Tracks an index of Floating Rate Treasury
Total return, 1 year +37.5% +4.1%
Its benchmark over the same days not measured +4.0% (TFLO)
Gap to its benchmark not measured +0.1 pts vs TFLO
Expense ratio 0.44% 0.15%
Holdings 245 4
Net assets, IBB as of Oct 27, 2026 and USFR as of May 31, 2026 $11.0bn $17.0bn

IBB and USFR on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

USFR

USFR tracks an index of Floating Rate Treasury. Over the year to Oct 28, 2026 it returned +4.1% with distributions reinvested, against +4.0% for its benchmark, the Bloomberg U.S. Treasury Floating Rate Bond Index. The prospectus expense ratio is 0.15% a year.

Questions people ask

Are IBB and USFR in the same category?
IBB is a thematic ETF and USFR is a bond ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or USFR?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and USFR +4.1%.
Which is cheaper, IBB or USFR?
USFR is cheaper, by 0.29 percentage points a year. That is about $29 on $10,000 held for a year. Fees come from each fund's prospectus.
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ETFIQ, IBB against USFR, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-usfr

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