Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs IVV: how they differ
IBB and IVV hold 1% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and iShares Core S&P 500 ETF.
What they hold in common
By the books each fund has filed, IBB and IVV hold 1% of their money in the same securities at the same weight.
| Holding | IBB | IVV |
|---|---|---|
| AMGEN INC | 7.85% | 0.32% |
| GILEAD SCIENCES | 7.44% | 0.27% |
| VERTEX PHARMACEUTICALS | 7.94% | 0.20% |
| BLK CSH FND TREASURY SL AGENCY | 0.12% | 0.18% |
| REGENERON PHARMACEUTICALS | 5.92% | 0.12% |
| MODERNA | 3.67% | 0.07% |
| BIOGEN | 2.33% | 0.05% |
| USD CASH | 0.05% | 0.10% |
| INCYTE CORP | 1.81% | 0.03% |
| BIO TECHNE | 0.83% | 0.02% |
| CHARLES RIVER LABORATORIES INTERNA | 0.96% | 0.02% |
| CASH COLLATERAL USD SGAFT | 0.01% | 0.02% |
| Only in IBB | Only in IVV |
|---|---|
| ARGENX SE ADR 3.78% | NVIDIA 8.06% |
| NATERA 3.30% | APPLE 7.31% |
| REVOLUTION MEDICINES 2.87% | MICROSOFT 5.58% |
| ALNYLAM PHARMACEUTICALS 2.44% | AMAZON.COM INC 3.76% |
| ILLUMINA INC 2.25% | ALPHABET CLASS A 2.98% |
| INSMED 2.02% | BROADCOM INC 2.61% |
| BEONE MEDICINES AG 2.01% | ALPHABET CLASS C 2.38% |
| ROIVANT SCIENCES LTD 1.56% | META PLATFORMS CLASS A 2.16% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 10, 2026.
| IBB iShares Biotechnology ETF | IVV iShares Core S&P 500 ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | iShares |
| What it is | Biotechnology | S&P 500 |
| Total return, 1 year | +41.5% | +17.6% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | +0.1 pts |
| Expense ratio | 0.44% | 0.03% |
| Already in the S&P 500 | 35.6% | 100.0% |
| Holdings | 233 | 505 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Sep 10, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 233 positions, with the top ten at 47.5%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
IVV in plain words
IVV is an index equity fund tracking the S&P 500. Over the year to Sep 11, 2026 it returned +17.6% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.03% a year. By its holdings filed for Sep 10, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 505 positions, with the top ten at 38.1%.
Questions people ask
- Which returned more over the last year, IBB or IVV?
- In the year to Sep 13, 2026, with distributions reinvested, IBB returned +41.5% and IVV returned +17.6%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or IVV?
- IBB charges 0.44% a year and IVV charges 0.03%, so IVV is cheaper. Fees come from each fund's prospectus.
- How much do IBB and IVV overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 100% of IVV by weight is stocks the S&P 500 already holds. Between the two funds, 1% of their books are the same securities at the same weight.
Other comparisons
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against IVV, data as of Sep 13, 2026. https://etfiq.com/compare/any/ibb-vs-ivv Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources