Data as of Oct 28, 2026.

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IBB vs IVV: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to IVV's +13.7%, and IVV charges 0.03% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $11.0bn for iShares Biotechnology ETF and $885.1bn for iShares Core S&P 500 ETF.

At a glance
+37.5%
IBB total return, 1 year
+13.7%
IVV total return, 1 year
0.44%
IBB expense ratio
0.03%
IVV expense ratio

Pair scorecard

IVV costs 0.41 points a year less; their one-year returns differ by 23.8 points; IVV is far larger, $885.1bn against $11.0bn.

IBB vs IVV: Differences, Returns & Fees
MeasureIBBIVV
Return
Total return, 1 year+37.5%+13.7%
Benchmark
What it tracksBiotechS&P 500
Cost and size
Expense ratio0.44%0.03%
Net assets, as of Oct 27, 2026$11.0bn$885.1bn
Active share vs the S&P 50099%
Holdings
Holdings in common1%
Top ten holdings, share of the fund50%38.1%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

1%

By the books each fund has filed, IBB and IVV hold 1% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

1% in common

Positions both hold · largest shared weight first IBB IVV
AMGEN INC 8.20% 0.36%
GILEAD SCIENCES 8.56% 0.30%
VERTEX PHARMACEUTICALS 7.53% 0.20%
REGENERON PHARMACEUTICALS 5.64% 0.12%
MODERNA 5.29% 0.12%
ILLUMINA INC 2.93% 0.06%
BIOGEN 2.58% 0.06%
INCYTE CORP 1.63% 0.03%
CHARLES RIVER LABORATORIES INTERNA 1.18% 0.03%
BIO TECHNE 0.79% 0.02%
Only in one fund ↓
Only in IBB
NATERA 3.85%
ARGENX SE ADR 3.42%
REVOLUTION MEDICINES 2.50%
BEONE MEDICINES AG 2.15%
ALNYLAM PHARMACEUTICALS 2.11%
GENMAB SPONSORED ADR 1.72%
UNITED THERAPEUTICS 1.71%
INSMED 1.42%
Only in IVV
NVIDIA 7.92%
APPLE 7.61%
MICROSOFT 5.93%
AMAZON.COM INC 3.73%
ALPHABET CLASS A 2.83%
BROADCOM INC 2.45%
ALPHABET CLASS C 2.26%
META PLATFORMS CLASS A 2.05%
Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF IVV iShares Core S&P 500 ETF
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks the S&P 500
Total return, 1 year +37.5% +13.7%
Its benchmark over the same days not measured +13.6% (SPY)
Gap to its benchmark not measured +0.1 pts vs SPY
Expense ratio 0.44% 0.03%
Already in the S&P 500 40.2% 99.8%
Holdings 245 505
Net assets, as of Oct 27, 2026 $11.0bn $885.1bn

IBB and IVV on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

IVV

IVV tracks the S&P 500. Over the year to Oct 28, 2026 it returned +13.7% with distributions reinvested, against +13.6% for its benchmark, the S&P 500. The prospectus expense ratio is 0.03% a year. By its holdings published by its issuer for Oct 27, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 505 positions, with the top ten at 38.1%.

Questions people ask

Are IBB and IVV in the same category?
IBB is a thematic ETF and IVV is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or IVV?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and IVV +13.7%.
Which is cheaper, IBB or IVV?
IVV is cheaper, by 0.41 percentage points a year. That is about $41 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and IVV overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 100% of IVV by weight is stocks the S&P 500 already holds.
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ETFIQ, IBB against IVV, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-ivv

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