Data as of Oct 28, 2026.

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IBB vs QUAL: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to QUAL's +13.1%, and QUAL charges 0.15% to IBB's 0.44%.

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Net assets: $11.0bn on Oct 27, 2026 for iShares Biotechnology ETF, and $48.2bn on Oct 28, 2026 for iShares MSCI USA Quality Factor ETF.

At a glance
+37.5%
IBB total return, 1 year
+13.1%
QUAL total return, 1 year
0.44%
IBB expense ratio
0.15%
QUAL expense ratio

Pair scorecard

QUAL costs 0.29 points a year less; their one-year returns differ by 24.4 points; QUAL is 4.5 times larger.

IBB vs QUAL: Differences, Returns & Fees
MeasureIBBQUAL
Return
Total return, 1 year+37.5%+13.1%
Benchmark
What it tracksBiotechMSCI USA Sector Neutral Quality Index
Cost and size
Expense ratio0.44%0.15%
Net assets, as of Oct 26, 2026$10.7bn$48.3bn
Active share vs the S&P 50099%
Holdings
Holdings in common1%
Top ten holdings, share of the fund50%44.5%

Holdings in common uses holdings dated Oct 27, 2026. Method

Risk and return

Jul 26, 2013 to Oct 23, 2026 · 691 weekly returns
IBB QUAL
Return
Total return edge QUAL +226.7% +444.7%
Annualized edge QUAL +9.3% +13.6%
Price return edge QUAL +217.3% +346.8%
Risk
Volatility edge QUAL 23.4% 16.2%
Max drawdown edge QUAL −37.5% −31.4%
Risk-adjusted
Sharpe edge QUAL 0.42 0.75
Sortino edge QUAL 0.61 1.09
Calmar edge QUAL 0.25 0.43
Reading

QUAL returned more: +444.7% to +226.7%. QUAL swung less: 16.2% to 23.4%. QUAL fell less at its worst: −31.4% to −37.5%.

Full scorecard

9 measures, with how each is measured
Open ↓
Risk and return: IBB vs QUAL: Differences, Returns & Fees
MeasureIBBQUALEdgeHow it is measured
Return
Total return+226.7%+444.7%QUALPrice change plus distributions, reinvested.
Annualized+9.3%+13.6%QUALTotal return as a yearly rate.
Price return+217.3%+346.8%QUALPrice change alone, distributions left out.
Risk
Volatility23.4%16.2%QUALSpread of weekly returns, annualized. Lower is steadier.
Downside deviation16.0%11.2%QUALLike volatility, counting only weeks below the Treasury bill rate.
Max drawdown−37.5%−31.4%QUALDeepest fall from a high to the low after it.
Risk-adjusted
Sharpe0.420.75QUALReturn above Treasury bills per unit of volatility.
Sortino0.611.09QUALReturn above Treasury bills per unit of downside deviation.
Calmar0.250.43QUALAnnualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 691 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

1%

By the books each fund has filed, IBB and QUAL hold 1% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

1% in common

Positions both hold · largest shared weight first IBB QUAL
GILEAD SCIENCES 8.56% 0.74%
VERTEX PHARMACEUTICALS 7.53% 0.45%
UNITED THERAPEUTICS 1.71% 0.08%
Only in one fund ↓
Only in IBB
AMGEN INC 8.20%
REGENERON PHARMACEUTICALS 5.64%
MODERNA 5.29%
NATERA 3.85%
ARGENX SE ADR 3.42%
ILLUMINA INC 2.93%
BIOGEN 2.58%
REVOLUTION MEDICINES 2.50%
Only in QUAL
MICROSOFT 8.09%
APPLE 7.38%
NVIDIA 6.28%
META PLATFORMS CLASS A 4.06%
ELI LILLY 4.04%
TJX 3.50%
VISA CLASS A 3.44%
LAM RESEARCH 2.84%
Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF QUAL iShares MSCI USA Quality Factor ETF
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks the MSCI USA Quality Factor
Total return, 1 year +37.5% +13.1%
Its benchmark over the same days not measured +13.6% (MLRG)
Gap to its benchmark not measured −0.5 pts vs MLRG
Expense ratio 0.44% 0.15%
Already in the S&P 500 40.2% 97.2%
Holdings 245 119
Net assets, IBB as of Oct 27, 2026 and QUAL as of Oct 28, 2026 $11.0bn $48.2bn

IBB and QUAL on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Client brief · page 1 of 2 Report BR-E52B01BCDC

IBB and QUAL do different jobs. What does each one do in a portfolio?

  1. What each follows. IBB follows Biotech and QUAL follows MSCI USA Sector Neutral Quality Index.
  2. Holdings in common. 1% of the weight is in the same securities (holdings dated Oct 27, 2026).
  3. One-year total return. Over 1 year to Oct 28, 2026 IBB returned +37.5% and QUAL +13.1% with distributions reinvested, a gap of 24.4 points.

Data as of Oct 28, 2026.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

QUAL

QUAL tracks the MSCI USA Quality Factor. Over the year to Oct 28, 2026 it returned +13.1% with distributions reinvested, against +13.6% for its benchmark, the MSCI USA Index. The prospectus expense ratio is 0.15% a year. By its holdings published by its issuer for Oct 27, 2026, 97% of the fund by weight is stocks the S&P 500 also holds, across 119 positions, with the top ten at 44.5%.

Questions people ask

Are IBB and QUAL in the same category?
IBB is a thematic ETF and QUAL is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or QUAL?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and QUAL +13.1%.
Which is cheaper, IBB or QUAL?
QUAL is cheaper, by 0.29 percentage points a year. That is about $29 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and QUAL overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 97% of QUAL by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, IBB against QUAL, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-qual

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