Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs SPYM: how they differ
IBB and SPYM hold 0% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and State Street(R) SPDR(R) Portfolio S&P 500(R) ETF.
What they hold in common
By the books each fund has filed, IBB and SPYM hold 0% of their money in the same securities at the same weight.
| Only in IBB | Only in SPYM |
|---|---|
| VERTEX PHARMACEUTICALS 7.94% | NVIDIA CORP 8.07% |
| AMGEN INC 7.85% | APPLE INC 7.32% |
| GILEAD SCIENCES 7.44% | MICROSOFT CORP 5.58% |
| REGENERON PHARMACEUTICALS 5.92% | AMAZON.COM INC 3.76% |
| ARGENX SE ADR 3.78% | ALPHABET INC CL A 2.98% |
| MODERNA 3.67% | BROADCOM INC 2.61% |
| NATERA 3.30% | ALPHABET INC CL C 2.38% |
| REVOLUTION MEDICINES 2.87% | META PLATFORMS INC CLASS A 2.16% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 10, 2026.
| IBB iShares Biotechnology ETF | SPYM State Street(R) SPDR(R) Portfolio S&P 500(R) ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | State Street |
| What it is | Biotechnology | S&P 500 |
| Total return, 1 year | +41.5% | +17.6% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | +0.1 pts |
| Expense ratio | 0.44% | 1.30% |
| Already in the S&P 500 | 35.6% | 100.0% |
| Holdings | 233 | 507 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Sep 10, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 233 positions, with the top ten at 47.5%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
SPYM in plain words
SPYM is an index equity fund tracking the S&P 500. Over the year to Sep 11, 2026 it returned +17.6% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 1.30% a year. By its holdings filed for Sep 10, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 507 positions, with the top ten at 38.1%.
Questions people ask
- Which returned more over the last year, IBB or SPYM?
- In the year to Sep 13, 2026, with distributions reinvested, IBB returned +41.5% and SPYM returned +17.6%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or SPYM?
- IBB charges 0.44% a year and SPYM charges 1.30%, so IBB is cheaper. Fees come from each fund's prospectus.
- How much do IBB and SPYM overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 100% of SPYM by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.
Other comparisons
Where to next
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against SPYM, data as of Sep 13, 2026. https://etfiq.com/compare/any/ibb-vs-spym Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources