Data as of Oct 28, 2026.

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IBB vs SPYM: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to SPYM's +13.7%, and SPYM charges 0.02% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $11.0bn for iShares Biotechnology ETF and $185.0bn for State Street SPDR Portfolio S&P 500 ETF.

At a glance
+37.5%
IBB total return, 1 year
+13.7%
SPYM total return, 1 year
0.44%
IBB expense ratio
0.02%
SPYM expense ratio

Pair scorecard

SPYM costs 0.42 points a year less; their one-year returns differ by 23.8 points; SPYM is 16.8 times larger.

IBB vs SPYM: Differences, Returns & Fees
MeasureIBBSPYM
Return
Total return, 1 year+37.5%+13.7%
Benchmark
What it tracksBiotechS&P 500 Index
Cost and size
Expense ratio0.44%0.02%
Net assets, as of Oct 27, 2026$11.0bn$185.0bn
Active share vs the S&P 50099%
Holdings
Holdings in common1%
Top ten holdings, share of the fund50%38.1%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

1%

By the books each fund has filed, IBB and SPYM hold 1% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

1% in common

Positions both hold · largest shared weight first IBB SPYM
AMGEN INC 8.20% 0.36%
GILEAD SCIENCES 8.56% 0.30%
VERTEX PHARMACEUTICALS 7.53% 0.20%
REGENERON PHARMACEUTICALS 5.64% 0.12%
MODERNA 5.29% 0.12%
ILLUMINA INC 2.93% 0.06%
BIOGEN 2.58% 0.06%
INCYTE CORP 1.63% 0.03%
CHARLES RIVER LABORATORIES INTERNA 1.18% 0.03%
BIO TECHNE 0.79% 0.02%
Only in one fund ↓
Only in IBB
NATERA 3.85%
ARGENX SE ADR 3.42%
REVOLUTION MEDICINES 2.50%
BEONE MEDICINES AG 2.15%
ALNYLAM PHARMACEUTICALS 2.11%
GENMAB SPONSORED ADR 1.72%
UNITED THERAPEUTICS 1.71%
INSMED 1.42%
Only in SPYM
NVIDIA CORP 7.92%
APPLE INC 7.61%
MICROSOFT CORP 5.92%
AMAZON.COM INC 3.73%
ALPHABET INC CL A 2.83%
BROADCOM INC 2.44%
ALPHABET INC CL C 2.26%
META PLATFORMS INC CLASS A 2.05%
Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF SPYM State Street SPDR Portfolio S&P 500 ETF
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks the S&P 500
Total return, 1 year +37.5% +13.7%
Its benchmark over the same days not measured +13.7% (IVV)
Gap to its benchmark not measured 0.0 pts vs IVV
Expense ratio 0.44% 0.02%
Already in the S&P 500 40.2% 99.8%
Holdings 245 506
Net assets, as of Oct 27, 2026 $11.0bn $185.0bn
Former ticker none SPLG

IBB and SPYM on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

SPYM

SPYM tracks the S&P 500. Over the year to Oct 28, 2026 it returned +13.7% with distributions reinvested, against +13.7% for its benchmark, the S&P 500 Index. The prospectus expense ratio is 0.02% a year. By its holdings published by its issuer for Oct 27, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 506 positions, with the top ten at 38.1%.

Questions people ask

Are IBB and SPYM in the same category?
IBB is a thematic ETF and SPYM is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or SPYM?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and SPYM +13.7%.
Which is cheaper, IBB or SPYM?
SPYM is cheaper, by 0.42 percentage points a year. That is about $42 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and SPYM overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 100% of SPYM by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, IBB against SPYM, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-spym

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.