As of Nov 4, 2026. Rebuilt every trading night.
The innovation ETFs least like the S&P 500
See 15 funds ranked by the share of each fund held in S&P 500 companies. Updated Nov 4, 2026. Every fund here is sold on innovation. The one at the top holds the least of the S&P 500, so it adds the most you do not already own.
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All 15, lowest first
15 of 15 · click a column to sort| # | Ticker | Fund | Weight in S&P 500 companies ↑ | Active share | Net assets | Fee |
|---|---|---|---|---|---|---|
| 1 | GXDW | Global X Dorsey Wright Thematic ETF | 0.0% | 100.0% | $6.0m | 0.50% |
| 2 | LFSC | F/m Emerald Life Sciences Innovation ETF | 0.0% | 100.0% | $126m | 0.54% |
| 3 | LENS | Sarmaya Thematic ETF | 16.0% | 98.9% | $67m | 0.79% |
| 4 | FMED | Fidelity Disruptive Medicine ETF | 21.8% | 97.5% | $52m | 0.50% |
| 5 | FITE | State Street SPDR S&P Kensho Future Secu | 26.9% | 95.3% | $153m | 0.45% |
| 6 | INVN | Alger Russell Innovation ETF | 32.5% | 98.5% | $9.6m | 0.55% |
| 7 | HTEC | ROBO Global Healthcare Technology and In | 32.7% | 97.9% | $69m | 0.68% |
| 8 | GTEK | Goldman Sachs Future Tech Leaders Equity | 33.0% | 96.5% | $209m | 0.75% |
| 9 | ARKK | ARK Innovation ETF | 36.2% | 85.7% | $5.9bn | 0.75% |
| 10 | BULD | Pacer BlueStar Engineering the Future ET | 36.4% | 97.3% | $8.6m | 0.49% |
| 11 | DTEC | ALPS Disruptive Technologies ETF | 41.3% | 93.5% | $78m | 0.50% |
| 12 | DTRE | First Trust Alerian Disruptive Technolog | 43.0% | 99.4% | $14m | 0.60% |
| 13 | FDFF | Fidelity Disruptive Finance ETF | 43.4% | 97.5% | $43m | 0.50% |
| 14 | QQQJ | Invesco NASDAQ Next Gen 100 ETF | 46.7% | 98.6% | $1.2bn | 0.15% |
| 15 | TMAT | Main Thematic Innovation ETF | 50.3% | 91.6% | $237m | 0.79% |
The 29 of 30 ETFs in the broad innovation and megatrends theme with a filed book, least overlap first, each measured against the S&P 500 holdings ETFIQ reads for the same date.
The rest of the method
Across the funds listed here the weight held in S&P 500 companies runs from 0.0% to 50.3%. A thematic fund is worth its fee only for the part of it you do not already own. The list sorts one published number, with no scoring or weighting. Every fund ETFIQ covers in this category is eligible, closed funds included.
Links are sources, not endorsements. A ranking is not a recommendation or an opinion.
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ETFIQ, The innovation ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies, data as of Nov 4, 2026. https://etfiq.com/rankings/themes-off-index-innovation
ETFIQ. (Nov 4, 2026). The innovation ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies. Retrieved from https://etfiq.com/rankings/themes-off-index-innovation
[The innovation ETFs least like the S&P 500, ranked by the share of each fund held in S&P 500 companies (ETFIQ, Nov 4, 2026)](https://etfiq.com/rankings/themes-off-index-innovation)
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