The health care sector ETFs that lost the most
IXJ lost the most over twelve months to May 2026: $478m.
Coverage
Twelve-month list: 22 funds with SEC filings for every month to May 2026, 76.9% of the group’s net assets. 1 funds’ filings report flows for the whole fund, all share classes, so they are not ranked here: VHT
Rank change
Against the last edition of this list: the previous trading day for 1W and 1M, the previous month for 12M. "new" means not in the top 25 last time
How these lists are built
Measure
Net flow: money in less money out, in dollars, over the window, leaving any round trip aside
12 months · Jun 2025 to May 2026
From SEC filings · 12 funds · the last month every filer has reportedFilings run about 60 days behind, so this list ends at the latest month every fund in the group has filed, printed in the heading and the title. Rank change is against last month’s edition.
| # | Fund | Name | Net flow | Share of assets | Rank change |
|---|---|---|---|---|---|
| 1 | IXJ | iShares Global Healthcare ETF | −$478m | · | same |
| 2 | XLV | State Street Health Care Select Sector SPDR ETF | −$301m | · | new |
| 3 | RSPH | Invesco S&P 500 Equal Weight Health Care ETF | −$168m | · | ▲ 1 |
| 4 | FXH | First Trust Health Care AlphaDEX Fund | −$140m | · | ▼ 1 |
| 5 | XHE | State Street SPDR S&P Health Care Equipment ETF | −$37.5m | · | same |
| 6 | PSCH | Invesco S&P SmallCap Health Care ETF | −$29.7m | · | same |
| 7 | PTH | Invesco Dorsey Wright Healthcare Momentum ETF | −$14.0m | · | ▲ 1 |
| 8 | IYH | iShares U.S. Healthcare ETF | −$12.7m | · | ▼ 6 |
| 9 | HRTS | Tema Heart & Health ETF | −$10.5m | · | ▼ 2 |
| 10 | XHS | State Street SPDR S&P Health Care Services ETF | −$3.2m | · | same |
| 11 | MEDX | Horizon Kinetics Medical ETF | −$1.6m | · | ▼ 2 |
| 12 | JDOC | JPMorgan Healthcare Leaders ETF | −$22k | · | new |
SEC Form N-PORT, item B.6, monthly, every fund with a filing for every month of the window.CSV
Other flow rankings
ETFIQ, The health care sector ETFs that lost the most, data as of Oct 8, 2026. https://etfiq.com/flows/rankings/segment/health/outflows/
ETFIQ is an independent publisher and makes no recommendations; a rank is a sort of one published figure, not an opinion.