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IBB vs IFRA: which is really different?

IBB and IFRA hold 0% of their weight in the same names, and IBB returned +36.1% over the year. iShares Biotechnology ETF and iShares U.S. Infrastructure ETF.

IFRA costs 0.14 points a year less; their one-year returns differ by 26.6 points; IBB is 2.6 times larger.

IBBIFRA
Expense ratio0.44%0.30%
Net assets, as of Oct 8, 2026$10.3bn$4.0bn
Total return, 1 year+36.1%+9.5%
What it tracksBiotechInfrastructure
Holdings in common0%
S&P 500, total return, 1 year+17.3%
Against the S&P 500, 1 yearahead by 18.8 ptsbehind by 7.8 pts
Below its all-time high10.6%, high on Jun 25, 2026

Holdings in common uses holdings dated Oct 8, 2026.

39.5%
IBB in the S&P 500
71.7%
IFRA in the S&P 500
+36.1%
IBB total return, 1 year
+9.5%
IFRA total return, 1 year
IBB · 1 year to Oct 9, 202661% of its weight is outside the S&P 500
61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 99% · top ten 50% of the fund · 245 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 33% in61% of its weight is outside the S&P 50040% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.40%61%in the S&P 500outside the S&P 500active share 99% · Nasdaq-100: 33% in

40% of IBB's weight is in S&P 500 companies and 61% is outside the index. Holdings as of Oct 8, 2026.

IFRA · 1 year to Oct 9, 202628% of its weight is outside the S&P 500
28% of its weight is outside the S&P 50072% of IFRA's weight is in S&P 500 companies and 28% is outside the index. Holdings as of Oct 8, 2026.72%28%of its weight in S&P 500 companiesoutside the S&P 500active share 96% · top ten 33% of the fund · 164 holdings as published by its issuer for Oct 8, 2026 · Nasdaq-100: 11% in28% of its weight is outside the S&P 50072% of IFRA's weight is in S&P 500 companies and 28% is outside the index. Holdings as of Oct 8, 2026.72%28%in the S&P 500outsideactive share 96% · Nasdaq-100: 11% in

72% of IFRA's weight is in S&P 500 companies and 28% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · IBB scores higherHow much of it is not the index it is sold as an alternative to?
0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, IBB and IFRA hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 8, 2026.

half

0% in common

Positions both hold, largest shared weight first
Holding IBB IFRA
Only in IBB
GILEAD SCIENCES 8.37%
AMGEN INC 7.89%
VERTEX PHARMACEUTICALS 7.69%
REGENERON PHARMACEUTICALS 5.40%
MODERNA 5.30%
NATERA 3.88%
ARGENX SE ADR 3.35%
ILLUMINA INC 2.94%
Only in IFRA
QUANTA SERVICES INC 4.08%
CATERPILLAR INC 4.07%
UNION PACIFIC 4.00%
NEXTERA ENERGY 3.86%
CSX 3.51%
SOUTHERN 2.92%
CONSTELLATION ENERGY CORP 2.85%
NORFOLK SOUTHERN CORP 2.85%

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

Total returnvs the S&P 500vs the Nasdaq-100
WindowIBBIFRAIBBIFRAIBBIFRA
3 months+7.5%−7.3%+4.1 pts−10.6 pts+3.9 pts−10.9 pts
6 months+21.9%−3.9%+6.8 pts−19.1 pts−1.3 pts−27.1 pts
1 year+36.1%+9.5%+18.8 pts−7.8 pts+12.5 pts−14.1 pts
3 years+69.1%+64.5%−16.7 pts−21.3 pts−38.2 pts−42.8 pts
Since launch
IBB Feb 2001 · IFRA Apr 2018
+525.3%+164.1%−299.7 pts−69.5 pts−936.3 pts−230.2 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

IBB
iShares Biotechnology ETF · Holds 245 stocks in biotech, 40% of its weight in S&P 500 companies
IFRA
iShares U.S. Infrastructure ETF · Holds 164 stocks in infrastructure, 72% of its weight in S&P 500 companies
Issuer iShares iShares
Theme Biotech Infrastructure
In the S&P 500 39.5% 71.7%
Active share vs the S&P 500 99.0% 95.7%
In the Nasdaq-100 33.1% 10.9%
Holdings 245 164
Top ten, share of the fund 49.9% 33.4%
Expense ratio 0.44% 0.30%
Fee for the differing part 0.44% 0.31%
Total return, 1 year +36.1% +9.5%
vs the S&P 500 +18.8 pts −7.8 pts
vs the Nasdaq-100 +12.5 pts −14.1 pts
Below its high −4.8% −10.6%
Net assets, as of Oct 8, 2026 $10.3bn $4.0bn

As of Oct 9, 2026. Source: ETFIQ.

IBB in plain words

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +36.1% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 18.8 pts.

IFRA in plain words

By weight, 72% of IFRA's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 33% of the fund across 164 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +9.5% with distributions reinvested against +17.3% for the S&P 500, so a holder was behind by 7.8 pts. It sits 10.6% below its all-time high of Jun 25, 2026.

Questions people ask

Do IBB and IFRA hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, IBB or IFRA?
IBB has 40% of its weight in S&P 500 names and IFRA has 72%, so IBB differs more from the index.
Which is cheaper, IBB or IFRA?
IBB charges 0.44% a year and IFRA charges 0.30%, so IFRA is cheaper. Fees come from each fund's prospectus.
Other comparisons
IBB vs IGFIBB vs PAVEIBB vs XMEIBB vs SILIFRA vs XBIIFRA vs ITAIFRA vs PPAIFRA vs IGV
IBB on its own →IFRA on its own →How every figure is computed →Standards and sources →
Where these figures came from
IBB and IFRA filings on SEC EDGAR ↗IBB and IFRA prospectus with the expense ratio (SEC) ↗iShares page for IBB ↗iShares page for IFRA ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, IBB against IFRA, data as of Oct 9, 2026. https://etfiq.com/compare/themes/ibb-vs-ifra

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.