Data as of Oct 28, 2026.

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IBB vs VB: Differences, Returns & Fees

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Over the year to Oct 28, 2026, IBB returned +37.5% to VB's +14.4%, and VB charges 0.03% to IBB's 0.44%.

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Net assets: $11.0bn on Oct 27, 2026 for iShares Biotechnology ETF, and $76.9bn on Sep 30, 2026 for Vanguard Morningstar Small-Cap ETF.

At a glance
+37.5%
IBB total return, 1 year
+14.4%
VB total return, 1 year
0.44%
IBB expense ratio
0.03%
VB expense ratio

Pair scorecard

VB costs 0.41 points a year less; their one-year returns differ by 23.1 points; VB is 6.9 times larger.

IBB vs VB: Differences, Returns & Fees
MeasureIBBVB
Return
Total return, 1 year+37.5%+14.4%
Drawdown
Below its high5.7%, high on Aug 14, 2026
Benchmark
What it tracksBiotechMorningstar US Small Cap Index
Cost and size
Expense ratio0.44%0.03%
Net assets, as of Sep 30, 2026$11.2bn$76.9bn
Active share vs the S&P 50099%
Holdings
Holdings in common7%
Top ten holdings, share of the fund50%5.9%

Holdings in common uses holdings dated Sep 30, 2026 and Oct 27, 2026. Method

What they share

7%

By the books each fund has filed, IBB and VB hold 7% of their money in the same securities at the same weight. Holdings dated Sep 30, 2026 and Oct 27, 2026.

0 half 100%

half

7% in common

Positions both hold · largest shared weight first IBB VB
NATERA 3.85% 0.72%
REVOLUTION MEDICINES 2.50% 0.53%
ILLUMINA INC 2.93% 0.52%
MODERNA 5.29% 0.44%
UNITED THERAPEUTICS 1.71% 0.29%
INCYTE CORP 1.63% 0.27%
ROIVANT SCIENCES LTD 1.33% 0.23%
NEUROCRINE BIOSCIENCES 1.02% 0.18%
CHARLES RIVER LABORATORIES INTERNA 1.18% 0.18%
MEDPACE HOLDINGS 1.06% 0.18%
EXELIXIS INC 1.09% 0.17%
TWIST BIOSCIENCE 0.71% 0.16%
Only in one fund ↓
Only in IBB
GILEAD SCIENCES 8.56%
AMGEN INC 8.20%
VERTEX PHARMACEUTICALS 7.53%
REGENERON PHARMACEUTICALS 5.64%
ARGENX SE ADR 3.42%
BIOGEN 2.58%
BEONE MEDICINES AG 2.15%
ALNYLAM PHARMACEUTICALS 2.11%
Only in VB
SLCMT1142 1.31%
Twilio Inc 0.57%
Everpure Inc 0.52%
Okta Inc 0.44%
EMCOR Group Inc 0.42%
Credo Technology Group Holding Ltd 0.42%
Jabil Inc 0.38%
Williams-Sonoma Inc 0.34%
Check overlap with more funds →

Side by side

IBB iShares Biotechnology ETF VB Vanguard Morningstar Small-Cap ETF
Where it sits Thematic ETF Stock ETF
What it is Biotech Tracks an index of Small-Cap
Total return, 1 year +37.5% +14.4%
Expense ratio 0.44% 0.03%
Already in the S&P 500 40.2% 21.6%
Holdings 245 1303
Net assets, IBB as of Oct 27, 2026 and VB as of Sep 30, 2026 $11.0bn $76.9bn

IBB and VB on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

VB

VB tracks an index of Small-Cap. Over the year to Oct 28, 2026 it returned +14.4% with distributions reinvested. The prospectus expense ratio is 0.03% a year. By its holdings published by its issuer as of Sep 30, 2026, 22% of the fund by weight is stocks the S&P 500 also holds, across 1,303 positions, with the top ten at 5.9%. It sat 5.7% below its high of Aug 14, 2026 on Oct 28, 2026.

Questions people ask

Are IBB and VB in the same category?
IBB is a thematic ETF and VB is a stock ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, IBB or VB?
In the year to Oct 28, 2026, with distributions reinvested, IBB returned +37.5% and VB +14.4%.
Which is cheaper, IBB or VB?
VB is cheaper, by 0.41 percentage points a year. That is about $41 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do IBB and VB overlap with the S&P 500?
By their latest filed holdings, 40% of IBB and 22% of VB by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, IBB against VB, data as of Oct 28, 2026. https://etfiq.com/compare/any/ibb-vs-vb

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Free to use with attribution for data ETFIQ computes; issuer data stays under its owner's terms.