Data as of Oct 28, 2026.

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FTXH vs IYH: Differences, Returns & Fees

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Over the year to Oct 28, 2026, FTXH returned +47.9% to IYH's +25.3%; 48% of their weight is in the same names.

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Net assets: $1.2bn on Oct 27, 2026 for First Trust Nasdaq Pharmaceuticals ETF, and $4.5bn on Oct 28, 2026 for iShares U.S. Healthcare ETF.

At a glance
+47.9%
FTXH total return, 1 year
+25.3%
IYH total return, 1 year
0.60%
FTXH expense ratio
0.37%
IYH expense ratio

Pair scorecard

IYH costs 0.23 points a year less; their one-year returns differ by 22.6 points; IYH is 3.8 times larger.

FTXH vs IYH: Differences, Returns & Fees
MeasureFTXHIYH
Return
Total return, 1 year+47.9%+25.3%
Benchmark
What it tracksNasdaq US Smart Pharmaceuticals IndexRussell 1000 Health Care RIC 22
Cost and size
Expense ratio0.60%0.37%
Net assets, as of Oct 27, 2026$1.2bn$4.5bn
Holdings
Holdings in common48%
Top ten holdings, share of the fund54.8%58.9%

Holdings in common uses holdings dated Oct 27, 2026. Method

Risk and return

Sep 30, 2016 to Oct 23, 2026 · 525 weekly returns
FTXH IYH
Return
Total return edge IYH +145.2% +185.1%
Annualized edge IYH +9.3% +10.9%
Price return edge IYH +116.4% +151.0%
Risk
Volatility edge IYH (slight) 18.3% 17.1%
Max drawdown edge IYH −28.9% −24.7%
Risk-adjusted
Sharpe edge IYH 0.44 0.55
Sortino edge IYH 0.63 0.79
Calmar edge IYH 0.32 0.44
Reading

IYH returned more: +185.1% to +145.2%. IYH swung slightly less: 17.1% to 18.3%. IYH fell less at its worst: −24.7% to −28.9%.

Full scorecard

9 measures, with how each is measured
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Risk and return: FTXH vs IYH: Differences, Returns & Fees
MeasureFTXHIYHEdgeHow it is measured
Return
Total return+145.2%+185.1%IYHPrice change plus distributions, reinvested.
Annualized+9.3%+10.9%IYHTotal return as a yearly rate.
Price return+116.4%+151.0%IYHPrice change alone, distributions left out.
Risk
Volatility18.3%17.1%IYH (slight)Spread of weekly returns, annualized. Lower is steadier.
Downside deviation12.8%11.9%IYH (slight)Like volatility, counting only weeks below the Treasury bill rate.
Max drawdown−28.9%−24.7%IYHDeepest fall from a high to the low after it.
Risk-adjusted
Sharpe0.440.55IYHReturn above Treasury bills per unit of volatility.
Sortino0.630.79IYHReturn above Treasury bills per unit of downside deviation.
Calmar0.320.44IYHAnnualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 525 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

48%

By the books each fund has filed, FTXH and IYH hold 48% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

48% in common

Positions both hold · largest shared weight first FTXH IYH
Eli Lilly and Company 7.62% 15.29%
AbbVie Inc. 7.68% 7.57%
Johnson & Johnson 6.95% 9.67%
Merck & Co., Inc. 6.60% 5.24%
Amgen Inc. 3.58% 3.61%
Gilead Sciences, Inc. 3.74% 2.95%
Pfizer Inc. 7.20% 2.53%
Vertex Pharmaceuticals Incorporated 3.29% 1.98%
Bristol-Myers Squibb Company 3.17% 1.88%
Regeneron Pharmaceuticals, Inc. 3.51% 1.21%
Moderna, Inc. 0.71% 1.13%
Illumina, Inc. 2.22% 0.63%
Only in one fund ↓
Only in FTXH
Iovance Biotherapeutics, Inc. 0.85%
10X Genomics, Inc. (Class A) 0.60%
Amneal Pharmaceuticals, Inc. 0.59%
Twist Bioscience Corporation 0.55%
Adaptive Biotechnologies Corporation 0.53%
Spyre Therapeutics, Inc. 0.53%
Ligand Pharmaceuticals Inc. (Class B) 0.52%
TG Therapeutics, Inc. 0.50%
Only in IYH
UNITEDHEALTH GROUP 5.54%
THERMO FISHER SCIENTIFIC 3.85%
ABBOTT LABORATORIES 2.67%
INTUITIVE SURGICAL 2.35%
DANAHER 2.19%
MEDTRONIC PLC 1.72%
STRYKER 1.56%
ELEVANCE HEALTH INC 1.37%
Check overlap with more funds →

Side by side

FTXH First Trust Nasdaq Pharmaceuticals ETF IYH iShares U.S. Healthcare ETF
Where it sits Stock ETF Stock ETF
What it is Tracks an index Tracks an index
Total return, 1 year +47.9% +25.3%
Expense ratio 0.60% 0.37%
Already in the S&P 500 68.0% 90.3%
Holdings 50 101
Net assets, FTXH as of Oct 27, 2026 and IYH as of Oct 28, 2026 $1.2bn $4.5bn

FTXH and IYH on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Client brief · page 1 of 2 Report BR-6400891B4E

FTXH and IYH are built for the same job. How do they differ in cost, holdings and results?

  1. What each follows. FTXH follows Nasdaq US Smart Pharmaceuticals Index and IYH follows Russell 1000 Health Care RIC 22.
  2. Holdings in common. 48% of the weight is in the same securities (holdings dated Oct 27, 2026).
  3. One-year total return. Over 1 year to Oct 28, 2026 FTXH returned +47.9% and IYH +25.3% with distributions reinvested, a gap of 22.6 points.

Data as of Oct 28, 2026.

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About each fund
FTXH

FTXH tracks an index. Over the year to Oct 28, 2026 it returned +47.9% with distributions reinvested. The prospectus expense ratio is 0.60% a year. By its holdings published by its issuer for Oct 27, 2026, 68% of the fund by weight is stocks the S&P 500 also holds, across 50 positions, with the top ten at 54.8%.

IYH

IYH tracks an index. Over the year to Oct 28, 2026 it returned +25.3% with distributions reinvested. The prospectus expense ratio is 0.37% a year. By its holdings published by its issuer for Oct 27, 2026, 90% of the fund by weight is stocks the S&P 500 also holds, across 101 positions, with the top ten at 58.9%.

Questions people ask

Which returned more over the last year, FTXH or IYH?
In the year to Oct 28, 2026, with distributions reinvested, FTXH returned +47.9% and IYH +25.3%.
Which is cheaper, FTXH or IYH?
IYH is cheaper, by 0.23 percentage points a year. That is about $23 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do FTXH and IYH overlap with the S&P 500?
By their latest filed holdings, 68% of FTXH and 90% of IYH by weight is stocks the S&P 500 already holds.
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ETFIQ, FTXH against IYH, data as of Oct 28, 2026. https://etfiq.com/compare/any/ftxh-vs-iyh

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