Data as of Oct 28, 2026.

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FTXH vs FXH: Differences, Returns & Fees

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Over the year to Oct 28, 2026, FTXH returned +47.9% to FXH's +21.5%; 30% of their weight is in the same names.

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Net assets on Oct 27, 2026: $1.2bn for First Trust Nasdaq Pharmaceuticals ETF and $1.1bn for First Trust Health Care AlphaDEX Fund.

At a glance
+47.9%
FTXH total return, 1 year
+21.5%
FXH total return, 1 year
0.60%
FTXH expense ratio
0.61%
FXH expense ratio

Pair scorecard

FTXH costs 0.01 points a year less; their one-year returns differ by 26.4 points; FTXH is 1.1 times larger.

FTXH vs FXH: Differences, Returns & Fees
MeasureFTXHFXH
Return
Total return, 1 year+47.9%+21.5%
Benchmark
What it tracksNasdaq US Smart Pharmaceuticals IndexStrataQuant Health Care Index
Cost and size
Expense ratio0.60%0.61%
Net assets, as of Oct 27, 2026$1.2bn$1.1bn
Holdings
Holdings in common30%
Top ten holdings, share of the fund54.8%24.7%

Holdings in common uses holdings dated Oct 27, 2026. Method

Risk and return

Sep 30, 2016 to Oct 23, 2026 · 525 weekly returns
FTXH FXH
Return
Total return edge FTXH +145.2% +126.9%
Annualized edge FTXH (slight) +9.3% +8.5%
Price return edge FXH (slight) +116.4% +122.1%
Risk
Volatility edge Tie 18.3% 18.6%
Max drawdown edge FTXH (slight) −28.9% −29.5%
Risk-adjusted
Sharpe edge FTXH 0.44 0.40
Sortino edge FTXH 0.63 0.56
Calmar edge FTXH 0.32 0.29
Reading

FTXH returned more: +145.2% to +126.9%. FTXH and FXH swung about the same: 18.3% and 18.6%. FTXH fell slightly less at its worst: −28.9% to −29.5%.

Full scorecard

9 measures, with how each is measured
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Risk and return: FTXH vs FXH: Differences, Returns & Fees
MeasureFTXHFXHEdgeHow it is measured
Return
Total return+145.2%+126.9%FTXHPrice change plus distributions, reinvested.
Annualized+9.3%+8.5%FTXH (slight)Total return as a yearly rate.
Price return+116.4%+122.1%FXH (slight)Price change alone, distributions left out.
Risk
Volatility18.3%18.6%TieSpread of weekly returns, annualized. Lower is steadier.
Downside deviation12.8%13.1%FTXH (slight)Like volatility, counting only weeks below the Treasury bill rate.
Max drawdown−28.9%−29.5%FTXH (slight)Deepest fall from a high to the low after it.
Risk-adjusted
Sharpe0.440.40FTXHReturn above Treasury bills per unit of volatility.
Sortino0.630.56FTXHReturn above Treasury bills per unit of downside deviation.
Calmar0.320.29FTXHAnnualized return divided by the max drawdown.

Computed by ETFIQ from Tiingo daily prices and ETFIQ's distribution records, 525 weekly returns. Cash rate: the 13-week Treasury bill.

What they share

30%

By the books each fund has filed, FTXH and FXH hold 30% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

30% in common

Positions both hold · largest shared weight first FTXH FXH
Exelixis, Inc. 2.50% 2.06%
Zoetis Inc. 3.49% 2.06%
Eli Lilly and Company 7.62% 2.04%
United Therapeutics Corporation 3.54% 2.01%
Regeneron Pharmaceuticals, Inc. 3.51% 1.98%
Amgen Inc. 3.58% 1.96%
Bristol-Myers Squibb Company 3.17% 1.82%
Halozyme Therapeutics, Inc. 1.77% 2.68%
Incyte Corporation 3.22% 1.77%
Jazz Pharmaceuticals Plc 2.26% 1.64%
Medpace Holdings, Inc. 1.60% 2.48%
AbbVie Inc. 7.68% 1.41%
Only in one fund ↓
Only in FTXH
Merck & Co., Inc. 6.60%
Gilead Sciences, Inc. 3.74%
Illumina, Inc. 2.22%
Charles River Laboratories International, Inc. 1.19%
Alnylam Pharmaceuticals, Inc. 1.12%
BioMarin Pharmaceutical Inc. 1.11%
Iovance Biotherapeutics, Inc. 0.85%
Moderna, Inc. 0.71%
Only in FXH
Centene Corporation 2.55%
The Cigna Group 2.53%
Globus Medical, Inc. (Class A) 2.49%
Zimmer Biomet Holdings, Inc. 2.49%
Universal Health Services, Inc. (Class B) 2.34%
Natera, Inc. 2.29%
Solventum Corporation 2.17%
DexCom, Inc. 2.10%
Check overlap with more funds →

Side by side

FTXH First Trust Nasdaq Pharmaceuticals ETF FXH First Trust Health Care AlphaDEX Fund
Where it sits Stock ETF Stock ETF
What it is Tracks an index Tracks an index
Total return, 1 year +47.9% +21.5%
Expense ratio 0.60% 0.61%
Already in the S&P 500 68.0% 59.2%
Holdings 50 72
Net assets, as of Oct 27, 2026 $1.2bn $1.1bn

FTXH and FXH on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

Client brief · page 1 of 2 Report BR-5CA8156701

FTXH and FXH are built for the same job. How do they differ in cost, holdings and results?

  1. What each follows. FTXH follows Nasdaq US Smart Pharmaceuticals Index and FXH follows StrataQuant Health Care Index.
  2. Holdings in common. 30% of the weight is in the same securities (holdings dated Oct 27, 2026).
  3. One-year total return. Over 1 year to Oct 28, 2026 FTXH returned +47.9% and FXH +21.5% with distributions reinvested, a gap of 26.4 points.

Data as of Oct 28, 2026.

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About each fund
FTXH

FTXH tracks an index. Over the year to Oct 28, 2026 it returned +47.9% with distributions reinvested. The prospectus expense ratio is 0.60% a year. By its holdings published by its issuer for Oct 27, 2026, 68% of the fund by weight is stocks the S&P 500 also holds, across 50 positions, with the top ten at 54.8%.

FXH

FXH tracks an index. Over the year to Oct 28, 2026 it returned +21.5% with distributions reinvested. The prospectus expense ratio is 0.61% a year. By its holdings published by its issuer for Oct 27, 2026, 59% of the fund by weight is stocks the S&P 500 also holds, across 72 positions, with the top ten at 24.7%.

Questions people ask

Which returned more over the last year, FTXH or FXH?
In the year to Oct 28, 2026, with distributions reinvested, FTXH returned +47.9% and FXH +21.5%.
Which is cheaper, FTXH or FXH?
FTXH is cheaper, by 0.01 percentage points a year. That is about $1 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do FTXH and FXH overlap with the S&P 500?
By their latest filed holdings, 68% of FTXH and 59% of FXH by weight is stocks the S&P 500 already holds.
Other comparisons
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ETFIQ, FTXH against FXH, data as of Oct 28, 2026. https://etfiq.com/compare/any/ftxh-vs-fxh

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