Data as of Oct 28, 2026.

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AVUS vs IBB: Differences, Returns & Fees

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Over the year to Oct 28, 2026, AVUS returned +18.0% to IBB's +37.5%, and AVUS charges 0.15% to IBB's 0.44%.

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Net assets on Oct 27, 2026: $14.8bn for Avantis U.S. Equity ETF and $11.0bn for iShares Biotechnology ETF.

At a glance
+18.0%
AVUS total return, 1 year
+37.5%
IBB total return, 1 year
0.15%
AVUS expense ratio
0.44%
IBB expense ratio

Pair scorecard

AVUS costs 0.29 points a year less; their one-year returns differ by 19.5 points; AVUS is 1.3 times larger.

AVUS vs IBB: Differences, Returns & Fees
MeasureAVUSIBB
Return
Total return, 1 year+18.0%+37.5%
Benchmark
What it tracksNo index, actively managedBiotech
Cost and size
Expense ratio0.15%0.44%
Net assets, as of Oct 27, 2026$14.8bn$11.0bn
Active share vs the S&P 50099%
Holdings
Holdings in common2%
Top ten holdings, share of the fund30.0%50%

Holdings in common uses holdings dated Oct 27, 2026. Method

What they share

2%

By the books each fund has filed, AVUS and IBB hold 2% of their money in the same securities at the same weight. Holdings dated Oct 27, 2026.

0 half 100%

half

2% in common

Positions both hold · largest shared weight first AVUS IBB
GILEAD SCIENCES INC COMMON STOCK USD.001 0.47% 8.56%
AMGEN INC COMMON STOCK USD.0001 0.26% 8.20%
VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01 0.17% 7.53%
REGENERON PHARMACEUTICALS COMMON STOCK USD.001 0.14% 5.64%
EXELIXIS INC COMMON STOCK USD.001 0.09% 1.09%
MODERNA INC COMMON STOCK USD.0001 0.09% 5.29%
BIOGEN INC COMMON STOCK USD.0005 0.08% 2.58%
UNITED THERAPEUTICS CORP COMMON STOCK USD.01 0.08% 1.71%
ILLUMINA INC COMMON STOCK USD.01 0.06% 2.93%
HALOZYME THERAPEUTICS INC COMMON STOCK USD.001 0.04% 1.01%
INCYTE CORP COMMON STOCK USD.001 0.04% 1.63%
ALKERMES PLC COMMON STOCK USD.01 0.03% 0.50%
Only in one fund ↓
Only in AVUS
APPLE INC COMMON STOCK USD.00001 5.90%
NVIDIA CORP COMMON STOCK USD.001 5.54%
MICROSOFT CORP COMMON STOCK USD.00000625 4.71%
AMAZON.COM INC COMMON STOCK USD.01 3.39%
MICRON TECHNOLOGY INC COMMON STOCK USD.1 2.19%
META PLATFORMS INC CLASS A COMMON STOCK USD.000006 2.13%
ALPHABET INC CL A COMMON STOCK USD.001 1.89%
ALPHABET INC CL C COMMON STOCK USD.001 1.52%
Only in IBB
ARGENX SE ADR 3.42%
BEONE MEDICINES AG 2.15%
GENMAB SPONSORED ADR 1.72%
INSMED 1.42%
ASCENDIS PHARMA 1.06%
BRIDGEBIO PHARMA 0.85%
TWIST BIOSCIENCE 0.71%
MADRIGAL PHARMACEUTICALS 0.66%
Check overlap with more funds →

Side by side

AVUS Avantis U.S. Equity ETF IBB iShares Biotechnology ETF
Where it sits Stock ETF Thematic ETF
What it is Actively managed Biotech
Total return, 1 year +18.0% +37.5%
Its benchmark over the same days +13.3% (IWV) not measured
Gap to its benchmark +4.7 pts vs IWV not measured
Expense ratio 0.15% 0.44%
Already in the S&P 500 84.1% 40.2%
Holdings 1943 245
Net assets, as of Oct 27, 2026 $14.8bn $11.0bn

AVUS and IBB on the fields both publish, as of Oct 28, 2026. Source: ETFIQ.

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About each fund
AVUS

Over the year to Oct 28, 2026 it returned +18.0% with distributions reinvested, against +13.3% for its benchmark, the Russell 3000.

AVUS is actively managed and tracks no index. The prospectus expense ratio is 0.15% a year. By its holdings published by its issuer for Oct 27, 2026, 84% of the fund by weight is stocks the S&P 500 also holds, across 1,943 positions, with the top ten at 30.0%.

IBB

By weight, 40% of IBB's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 245 positions, as published by its issuer for Oct 27, 2026. Over the year to Oct 28, 2026 the fund returned +37.5% with distributions reinvested.

Questions people ask

Are AVUS and IBB in the same category?
AVUS is a stock ETF and IBB is a thematic ETF, so they do different jobs. The table compares what both publish: return, cost and holdings.
Which returned more over the last year, AVUS or IBB?
In the year to Oct 28, 2026, with distributions reinvested, AVUS returned +18.0% and IBB +37.5%.
Which is cheaper, AVUS or IBB?
AVUS is cheaper, by 0.29 percentage points a year. That is about $29 on $10,000 held for a year. Fees come from each fund's prospectus.
How much do AVUS and IBB overlap with the S&P 500?
By their latest filed holdings, 84% of AVUS and 40% of IBB by weight is stocks the S&P 500 already holds.
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ETFIQ, AVUS against IBB, data as of Oct 28, 2026. https://etfiq.com/compare/any/avus-vs-ibb

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