Data as of .
HLTH vs WISE: which is really different?
HLTH and WISE hold 0% of their weight in the same names.
ETFIQ Off-Index Score: HLTH scores higher
How much of it is not the index it is sold as an alternative to?
A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed
0% of the two portfolios are the same securities at the same weight.
What they hold in common
By the books each fund has filed, HLTH and WISE hold 0% of their money in the same securities at the same weight.
| Only in HLTH | Only in WISE |
|---|---|
| 10X GENOMICS INC 7.67% | NVIDIA Corp 5.22% |
| TWIST BIOSCIENCE CORP 6.52% | Advanced Micro Devices Inc 5.12% |
| ILLUMINA INC 5.44% | Snowflake Inc 4.92% |
| NATERA INC 5.11% | Information Services Group Inc 4.45% |
| CYTOKINETICS INC 4.61% | Alphabet Inc 4.43% |
| INTUITIVE SURGICAL INC 4.36% | Kingsoft Cloud Holdings Ltd 4.29% |
| REVOLUTION MEDICINES INC 4.28% | Palantir Technologies Inc 4.08% |
| VERTEX PHARMACEUTICALS INC 4.08% | Caris Life Sciences Inc 4.06% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Sep 18, 2026 and Sep 21, 2026.
Performance, window by window
| Window | Total return | vs the S&P 500 | vs the Nasdaq-100 | |||
|---|---|---|---|---|---|---|
| HLTH | WISE | HLTH | WISE | HLTH | WISE | |
| 3 months | not published | −13.3% | not published | −15.6 pts | not published | −10.8 pts |
| 6 months | not published | +7.5% | not published | −10.5 pts | not published | −16.8 pts |
| 1 year | not published | −17.1% | not published | −33.7 pts | not published | −38.9 pts |
| Since launch | +15.8% | +42.7% | +13.7 pts | −28.9 pts | +14.0 pts | −44.1 pts |
| HLTH Tema Healthcare AI ETF Holds 32 stocks in artificial intelligence, 19% of its weight in S&P 500 companies | WISE Themes Generative Artificial Intelligence ETF Holds 40 stocks in artificial intelligence, 32% of its weight in S&P 500 companies | |
|---|---|---|
| Issuer | Tema | Themes |
| Theme | Artificial intelligence | Artificial intelligence |
| In the S&P 500 | 19.2% | 32.4% |
| Active share vs the S&P 500 | 99.2% | 83.6% |
| In the Nasdaq-100 | 11.9% | 29.2% |
| Holdings | 32 | 40 |
| Top ten, share of the fund | 49.9% | 51.4% |
| Expense ratio | 0.75% | 0.35% |
| Fee for the differing part | 0.76% | 0.42% |
| Total return, 1 year | +15.8% (since launch on Jul 21, 2026) | −17.1% |
| vs the S&P 500 | +13.7 pts | −33.7 pts |
| vs the Nasdaq-100 | +14.0 pts | −38.9 pts |
| Below its high | −2.1% | −24.0% |
| Net assets | not published | $28m |
HLTH in plain words
By weight, 19% of HLTH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 32 positions, as published by its issuer for Sep 18, 2026. Since it launched on Jul 21, 2026 the fund returned +15.8% with distributions reinvested against +2.0% for the S&P 500, so a holder was ahead by 13.7 pts.
WISE in plain words
By weight, 32% of WISE's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 84%. The top ten holdings are 51% of the fund across 40 positions, as published by its issuer for Sep 21, 2026. Over the year to Sep 18, 2026 the fund returned −17.1% with distributions reinvested against +16.6% for the S&P 500, so a holder was behind by 33.7 pts. It sits 24.0% below its all-time high of Oct 15, 2025.
Questions people ask
- Do HLTH and WISE hold the same stocks?
- By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
- Which is more different from the S&P 500, HLTH or WISE?
- HLTH has 19% of its weight in S&P 500 names and WISE has 32%, so HLTH differs more from the index.
- Which is cheaper, HLTH or WISE?
- HLTH charges 0.75% a year and WISE charges 0.35%, so WISE is cheaper. Fees come from each fund's prospectus.
Other comparisons
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, HLTH against WISE, data as of Sep 18, 2026. https://etfiq.com/compare/themes/hlth-vs-wise Free to use with attribution; the underlying files are at Open data.