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Data as of .

EPAI vs HLTH: which is really different?

EPAI and HLTH hold 0% of their weight in the same names.

Harbor AI Inflection Strategy ETF and Tema Healthcare AI ETF.

58.0%EPAI in the S&P 500
19.2%HLTH in the S&P 500
+33.6%EPAI total return, 1 year
+15.8%HLTH total return, 1 year

ETFIQ Off-Index Score: HLTH scores higher

How much of it is not the index it is sold as an alternative to?

EPAI 34.3HLTH 65.80.1, the lowest in this set91.8, the highest

A percentile among the 379 thematic ETFs with a holdings filing. It is a position in a set, not a rating, and neither end of it is a recommendation. All thematic ETFs ranked by it · How it is computed

EPAI42% of its weight is outside the S&P 500 · 6 months to Sep 18, 2026
58%42%of its weight in S&P 500 companiesof its weight outside the S&P 500active share 96% · top ten 38% of the fund · 37 holdings filed Apr 30, 2026 · Nasdaq-100: 19% in58%42%in the S&P 500outsideactive share 96% · top ten 38% of the fund
HLTH81% of its weight is outside the S&P 500 · since launch to Sep 18, 2026
19%81%in the S&P 500of its weight outside the S&P 500active share 99% · top ten 50% of the fund · 32 holdings filed Sep 18, 2026 · Nasdaq-100: 12% in19%81%inoutside the S&P 500active share 99% · top ten 50% of the fund

0% of the two portfolios are the same securities at the same weight.

What they hold in common

By the books each fund has filed, EPAI and HLTH hold 0% of their money in the same securities at the same weight.

Only in each
Only in EPAIOnly in HLTH
Vertiv Holdings Co 4.76%10X GENOMICS INC 7.67%
Teradyne Inc 4.25%TWIST BIOSCIENCE CORP 6.52%
FormFactor Inc 3.98%ILLUMINA INC 5.44%
MasTec Inc 3.82%NATERA INC 5.11%
Applied Materials Inc 3.65%CYTOKINETICS INC 4.61%
Monolithic Power Systems Inc 3.61%INTUITIVE SURGICAL INC 4.36%
Taiwan Semiconductor Manufacturing Co Lt 3.61%REVOLUTION MEDICINES INC 4.28%
Everus Construction Group Inc 3.48%VERTEX PHARMACEUTICALS INC 4.08%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Sep 18, 2026.

Performance, window by window

EPAI and HLTH over each window. Every figure is an ETFIQ calculation with distributions reinvested. Source: ETFIQ.
WindowTotal returnvs the S&P 500vs the Nasdaq-100
EPAIHLTHEPAIHLTHEPAIHLTH
3 months−13.1%not published−15.3 ptsnot published−10.6 ptsnot published
6 months+19.2%not published+1.2 ptsnot published−5.0 ptsnot published
Since launch+33.6%+15.8%+19.8 pts+13.7 pts+14.8 pts+14.0 pts
Open the live comparison on ETFIQ
EPAI and HLTH on the same fields, as of Sep 18, 2026. Source: ETFIQ.
EPAI
Harbor AI Inflection Strategy ETF
Holds 37 stocks in artificial intelligence, 58% of its weight in S&P 500 companies
HLTH
Tema Healthcare AI ETF
Holds 32 stocks in artificial intelligence, 19% of its weight in S&P 500 companies
IssuerHarborTema
ThemeArtificial intelligenceArtificial intelligence
In the S&P 50058.0%19.2%
Active share vs the S&P 50095.5%99.2%
In the Nasdaq-10019.0%11.9%
Holdings3732
Top ten, share of the fund37.9%49.9%
Expense ratio0.88%0.75%
Fee for the differing part0.92%0.76%
Total return, 1 year+33.6% (since launch on Dec 18, 2025)+15.8% (since launch on Jul 21, 2026)
vs the S&P 500+19.8 pts+13.7 pts
vs the Nasdaq-100+14.8 pts+14.0 pts
Below its high−16.8%−2.1%
Net assets$5mnot published

EPAI in plain words

By weight, 58% of EPAI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 96%. The top ten holdings are 38% of the fund across 37 positions, as filed for Apr 30, 2026. Since it launched on Dec 18, 2025 the fund returned +33.6% with distributions reinvested against +13.8% for the S&P 500, so a holder was ahead by 19.8 pts. It sits 16.8% below its all-time high of Jun 30, 2026.

HLTH in plain words

By weight, 19% of HLTH's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 99%. The top ten holdings are 50% of the fund across 32 positions, as published by its issuer for Sep 18, 2026. Since it launched on Jul 21, 2026 the fund returned +15.8% with distributions reinvested against +2.0% for the S&P 500, so a holder was ahead by 13.7 pts.

Questions people ask

Do EPAI and HLTH hold the same stocks?
By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, EPAI or HLTH?
EPAI has 58% of its weight in S&P 500 names and HLTH has 19%, so HLTH differs more from the index.
Which is cheaper, EPAI or HLTH?
EPAI charges 0.88% a year and HLTH charges 0.75%, so HLTH is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

EPAI against HLTH, ETFIQ, data as of Sep 18, 2026. Every figure is calculated from a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, EPAI against HLTH, data as of Sep 18, 2026. https://etfiq.com/compare/themes/epai-vs-hlth Free to use with attribution; the underlying files are at Open data.

How every figure is computed · Standards and sources