Do XBI and XME hold the same stocks?

By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.

Which is more different from the S&P 500, XBI or XME?

XBI has 13% of its weight in S&P 500 names and XME has 20%, so XME differs more from the index.

Which is cheaper, XBI or XME?

XBI and XME both charge 0.35% a year, so neither is cheaper. Fees come from each fund's prospectus.

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XBI vs XME: which is really different?

XBI and XME hold 0% of their weight in the same names, and XBI returned +45.0% over the year. State Street(R) SPDR(R) S&P(R) Biotech ETF and State Street(R) SPDR(R) S&P(R) Metals & Mining ETF.

Both cost 0.35% a year; their one-year returns differ by 40.8 points; XBI is 2.4 times larger.

	XBI	XME
Expense ratio	0.35%	0.35%
Net assets, as of Oct 8, 2026	$9.9bn	$4.1bn
Total return, 1 year	+45.0%	+4.2%
What it tracks	Biotech	Miners and metals
Holdings in common	0%
S&P 500, total return, 1 year	+17.3%
Against the S&P 500, 1 year	ahead by 27.7 pts	behind by 13.0 pts
Below its all-time high	11.1%, high on Feb 8, 2021	19.8%, high on Jun 2, 2026

Holdings in common uses holdings dated Oct 8, 2026.

12.7%

XBI in the S&P 500

20.3%

XME in the S&P 500

+45.0%

XBI total return, 1 year

+4.2%

XME total return, 1 year

XBI · 1 year to Oct 9, 202687% of its weight is outside the S&P 500

13% of XBI's weight is in S&P 500 companies and 87% is outside the index. Holdings as of Oct 8, 2026.

XME · 1 year to Oct 9, 202680% of its weight is outside the S&P 500

20% of XME's weight is in S&P 500 companies and 80% is outside the index. Holdings as of Oct 8, 2026.

ETFIQ Off-Index Score · XME scores higherHow much of it is not the index it is sold as an alternative to?

XBI 55.2

XME 72.6

0.1, the lowest in this set92.3, the highest

A percentile among the 391 thematic ETFs with a holdings filing. All thematic ETFs ranked by it → How it is computed →

What they hold in common

By the books each fund has filed, XBI and XME hold 0% of their money in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice. Holdings dated Oct 8, 2026.

50%

half

0% in common

Positions both hold, largest shared weight first

Holding XBI XME

Only in XBI

MODERNA INC 2.20%

TWIST BIOSCIENCE CORP 1.84%

NATERA INC 1.79%

ABBVIE INC 1.65%

UNITED THERAPEUTICS CORP 1.59%

AMGEN INC 1.58%

BIOGEN INC 1.57%

HALOZYME THERAPEUTICS INC 1.55%

Only in XME

CLEVELAND CLIFFS INC 5.44%

RELIANCE INC 5.42%

STEEL DYNAMICS INC 5.25%

MATERION CORP 5.17%

NUCOR CORP 5.15%

FREEPORT MCMORAN INC 5.04%

COMMERCIAL METALS CO 4.94%

NEWMONT CORP 4.84%

0% of the two portfolios are the same securities at the same weight.

Performance, window by window

	Total return		vs the S&P 500		vs the Nasdaq-100
Window	XBI	XME	XBI	XME	XBI	XME
3 months	−3.3%	+2.6%	−6.7 pts	−0.8 pts	−7.0 pts	−1.0 pts
6 months	+18.9%	−6.2%	+3.8 pts	−21.4 pts	−4.3 pts	−29.4 pts
1 year	+45.0%	+4.2%	+27.7 pts	−13.0 pts	+21.4 pts	−19.4 pts
3 years	+114.6%	+107.5%	+28.8 pts	+21.7 pts	+7.3 pts	+0.2 pts
Since launch XBI Feb 2006 · XME Jun 2006	+890.7%	+204.2%	+92.2 pts	−602.0 pts	−1,164.7 pts	−1,995.8 pts

Source: ETFIQ. Open the live comparison on ETFIQ →

On the same fields

XBI

State Street(R) SPDR(R) S&P(R) Biotech ETF · Holds 165 stocks in biotech, 13% of its weight in S&P 500 companies

XME

State Street(R) SPDR(R) S&P(R) Metals & Mining ETF · Holds 38 stocks in miners and metals, 20% of its weight in S&P 500 companies

Issuer State Street State Street

Theme Biotech Miners and metals

In the S&P 500 12.7% 20.3%

Active share vs the S&P 500 98.4% 99.6%

In the Nasdaq-100 8.5% 0.0%

Holdings 165 38

Top ten, share of the fund 16.9% 50.6%

Expense ratio 0.35% 0.35%

Fee for the differing part 0.36% 0.35%

Total return, 1 year +45.0% +4.2%

vs the S&P 500 +27.7 pts −13.0 pts

vs the Nasdaq-100 +21.4 pts −19.4 pts

Below its high −11.1% −19.8%

Net assets, as of Oct 8, 2026 $9.9bn $4.1bn

As of Oct 9, 2026. Source: ETFIQ.

XBI in plain words

By weight, 13% of XBI's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 98%. The top ten holdings are 17% of the fund across 165 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +45.0% with distributions reinvested against +17.3% for the S&P 500, so a holder was ahead by 27.7 pts. It sits 11.1% below its all-time high of Feb 8, 2021.

XME in plain words

By weight, 20% of XME's portfolio is stocks that are also in the S&P 500; its active share against the S&P 500 is 100%. The top ten holdings are 51% of the fund across 38 positions, as published by its issuer for Oct 8, 2026. Over the year to Oct 9, 2026 the fund returned +4.2% with distributions reinvested against +17.3% for the S&P 500, so a holder was behind by 13.0 pts. It sits 19.8% below its all-time high of Jun 2, 2026.

Questions people ask

Do XBI and XME hold the same stocks?: By their latest filings, 0% of their books are the same securities at the same weight, which is mostly different names. Overlap is the sum of the smaller weight of every security they share.
Which is more different from the S&P 500, XBI or XME?: XBI has 13% of its weight in S&P 500 names and XME has 20%, so XME differs more from the index.
Which is cheaper, XBI or XME?: XBI and XME both charge 0.35% a year, so neither is cheaper. Fees come from each fund's prospectus.

Other comparisons

XBI vs XT XBI vs ARTY XBI vs SIL XBI vs KWEB XME vs IBB XME vs AIQ XME vs BOTZ XME vs AIRR

XBI on its own →XME on its own →How every figure is computed →Standards and sources →

Where these figures came from

XBI and XME filings on SEC EDGAR ↗XBI and XME prospectus with the expense ratio (SEC) ↗State Street website ↗

ETFIQ links to the documents behind every figure; a link is not an endorsement. A comparison is not a recommendation.

How this is computed

It is a position in a set, not a rating, and neither end of it is a recommendation.

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed.

Every figure is an ETFIQ calculation with distributions reinvested.

Cite this page

ETFIQ, XBI against XME, data as of Oct 9, 2026. https://etfiq.com/compare/themes/xbi-vs-xme

Open data

Free to use with attribution for figures ETFIQ computes; issuer data stays under its owner's terms.