GNOM · Global X Genomics & Biotechnology ETF
GNOM holds 50 stocks. 98% of it is not in the S&P 500, and its top ten are 43% of the fund.
Its ten largest positions
| Holding | Ticker | Weight | |
|---|---|---|---|
| GUARDANT HEALTH, INC. | 5.60% | ||
| ILLUMINA, INC. | 4.83% | ||
| NATERA, INC. | 4.16% | ||
| BIOMARIN PHARMACEUTICAL INC. | 4.09% | ||
| ARROWHEAD PHARMACEUTICALS, INC. | 4.07% | ||
| Legend Biotech Corp | 4.05% | ||
| Praxis Precision Medicines Inc | 4.01% | ||
| Twist Bioscience Corp | 3.97% | ||
| VERTEX PHARMACEUTICALS INCORPORATED | 3.95% | ||
| CRISPR Therapeutics AG | 3.85% |
Period by period
| Window | Total return | S&P 500 | Gap to S&P 500 | Gap to Nasdaq-100 |
|---|---|---|---|---|
| 3 months | +32.5% | +4.7% | +27.8 pts | +30.4 pts |
| 6 months | +42.3% | +15.2% | +27.1 pts | +22.1 pts |
| 1 year | +75.7% | +20.0% | +55.8 pts | +50.1 pts |
| 3 years | +46.0% | +78.0% | −31.9 pts | −47.4 pts |
| Since launch | +6.3% | +197.5% | −191.2 pts | −299.5 pts |
In plain words
The top ten holdings are 43% of the fund across 50 positions, as filed for May 31, 2026. Over the year to Sep 4, 2026 the fund returned +75.7% with distributions reinvested against +20.0% for the S&P 500, so a holder was ahead by 55.8 pts. It sits 41.5% below its all-time high of Feb 8, 2021.
| Theme (ETFIQ, editorial) | Genomics and biotech innovation |
|---|---|
| Launched | Apr 10, 2019 |
| Already in the S&P 500, by weight (ETFIQ) | 17.9% |
| Active share vs the S&P 500 (ETFIQ) | 97.6% |
| Already in the Nasdaq-100, by weight (ETFIQ) | 5.9% |
| Active share vs the Nasdaq-100 (ETFIQ) | 98.8% |
| Top ten holdings weight | 42.6% |
| Holdings | 50 |
| Holdings as of (SEC N-PORT) | May 31, 2026 |
| Top holdings | GUARDANT HEALTH, INC. 5.6%, ILLUMINA, INC. 4.8%, NATERA, INC. 4.2%, BIOMARIN PHARMACEUTICAL INC. 4.1%, ARROWHEAD PHARMACEUTICALS, INC. 4.1%, Legend Biotech Corp 4.0%, Praxis Precision Medicines Inc 4.0%, Twist Bioscience Corp 4.0%, VERTEX PHARMACEUTICALS INCORPORATED 4.0%, CRISPR Therapeutics AG 3.9% |
| Net assets (SEC filing, whole fund, as filed for May 31, 2026) | $56m |
| Below its all-time high (ETFIQ) | −41.5% |
| Expense ratio (prospectus XBRL) | 0.50% |
| Fee for the part that differs from the S&P 500, active expense ratio (ETFIQ) | 0.51% |
| Closest funds by holdings overlap | ARKG 37%, HELX 30%, EKG 25%, HTEC 22%, IDNA 20% |
Holdings from the fund’s latest public SEC N-PORT filing; overlap and active share computed by ETFIQ against the IVV and QQQM books; returns from Tiingo end-of-day prices with distributions reinvested. How this desk computes every figure
Questions people ask
- How much of GNOM is already in the S&P 500?
- By its holdings filed for May 31, 2026, 18% of GNOM by weight is stocks the S&P 500 already holds. Its active share against the index is 98%, so that share is the part doing something different.
- What does GNOM hold?
- 50 positions as filed for May 31, 2026, with the top ten at 43% of the fund. The largest are GUARDANT HEALTH, INC. at 5.6%, ILLUMINA, INC. at 4.8%, NATERA, INC. at 4.2%.
- Has GNOM beaten the S&P 500?
- Over the year to Sep 4, 2026 GNOM returned +75.7% with distributions reinvested, against +20.0% for the S&P 500, so it finished ahead of the index by 55.8 points.
- What does GNOM cost?
- The prospectus expense ratio is 0.50% a year. Because 98% of the fund differs from the S&P 500, the fee on that differing part works out at 0.51%.
The words on this page
- Active share
- The part of the fund doing something the index is not, as a percentage. It is the part a fee is actually buying.
- Weight overlap
- The share of money two portfolios hold in the same securities at the same weight. Above 50%, holding both is close to holding one of them twice.
- Already in the index
- The fund’s weight in securities the S&P 500 holds at all. A fund can be made entirely of index names and still have high active share, because it holds them at very different weights.
- Top ten
- What the ten largest positions add up to. The higher it is, the more the fund is a bet on a few companies rather than a theme.
Every term this desk uses, defined in full on the themes desk vocabulary page.
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Funds near this one
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Cite this page. ETFIQ, GNOM on the themes desk, data as of Sep 4, 2026. https://etfiq.com/funds/GNOM.html Free to use with attribution; the underlying files are at Open data.