Data as of Sep 13, 2026. Both funds on the fields they both publish, from the same sources.
VOE vs XBI: how they differ
VOE and XBI hold 0% of their weight in the same names, and XBI returned more over the year.
Vanguard Mid-Cap Value Index Fund and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, VOE and XBI hold 0% of their money in the same securities at the same weight.
| Only in VOE | Only in XBI |
|---|---|
| Cummins Inc 1.71% | MODERNA INC 2.87% |
| Valero Energy Corp 1.34% | TWIST BIOSCIENCE CORP 1.81% |
| Marathon Petroleum Corp 1.29% | HALOZYME THERAPEUTICS INC 1.47% |
| CRH PLC 1.24% | NATERA INC 1.46% |
| United Rentals Inc 1.23% | KYMERA THERAPEUTICS INC 1.45% |
| General Motors Co 1.21% | TRAVERE THERAPEUTICS INC 1.40% |
| SLB Ltd 1.21% | ROIVANT SCIENCES LTD 1.39% |
| Simon Property Group Inc 1.20% | ORUKA THERAPEUTICS INC 1.38% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and Sep 10, 2026.
| VOE Vanguard Mid-Cap Value Index Fund | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Vanguard | State Street |
| What it is | Mid-Cap Value | SPDR S&P Biotech |
| Total return, 1 year | +20.2% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +2.7 pts | +46.5 pts |
| Expense ratio | 0.05% | 0.35% |
| Already in the S&P 500 | 96.6% | 8.5% |
| Holdings | 170 | 154 |
VOE in plain words
VOE is an index equity fund tracking the Mid-Cap Value. Over the year to Sep 11, 2026 it returned +20.2% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.05% a year. By its holdings filed for Jun 30, 2026, 97% of the fund by weight is stocks the S&P 500 also holds, across 170 positions, with the top ten at 12.7%.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Sep 10, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 154 positions, with the top ten at 15.9%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, VOE or XBI?
- In the year to Sep 13, 2026, with distributions reinvested, VOE returned +20.2% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, VOE or XBI?
- VOE charges 0.05% a year and XBI charges 0.35%, so VOE is cheaper. Fees come from each fund's prospectus.
- How much do VOE and XBI overlap with the S&P 500?
- By their latest filed holdings, 97% of VOE and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, VOE against XBI, data as of Sep 13, 2026. https://etfiq.com/compare/any/voe-vs-xbi Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources