Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
ONEQ vs XBI: how they differ
ONEQ and XBI hold 3% of their weight in the same names, and XBI returned more over the year.
Fidelity Nasdaq Composite Index ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, ONEQ and XBI hold 3% of their money in the same securities at the same weight.
| Holding | ONEQ | XBI |
|---|---|---|
| AMGEN INC | 0.40% | 1.00% |
| GILEAD SCIENCES INC | 0.36% | 0.97% |
| VERTEX PHARMACEUTICALS INC | 0.25% | 1.06% |
| REGENERON PHARMACEUTICALS INC | 0.14% | 0.96% |
| ALNYLAM PHARMACEUTICALS INC | 0.09% | 0.96% |
| NATERA INC | 0.07% | 1.17% |
| REVOLUTION MEDICINES INC | 0.07% | 1.21% |
| BIOGEN INC | 0.06% | 1.03% |
| UNITED THERAPEUTICS CORP DEL | 0.05% | 0.93% |
| INSMED INC | 0.05% | 1.08% |
| MODERNA INC | 0.04% | 1.41% |
| INCYTE CORP | 0.04% | 1.00% |
| Only in ONEQ | Only in XBI |
|---|---|
| NVIDIA CORP 11.24% | Roivant Sciences Ltd 1.16% |
| APPLE INC 10.04% | Alkermes PLC 1.11% |
| MICROSOFT CORP 7.32% | AbbVie Inc 1.04% |
| AMAZON.COM INC 6.37% | uniQure NV 1.03% |
| ALPHABET INC 4.85% | CRISPR Therapeutics AG 1.02% |
| BROADCOM INC 4.64% | Arcus Biosciences Inc 0.74% |
| ALPHABET INC 4.48% | Absci Corp 0.56% |
| TESLA INC 3.58% | Biohaven Ltd 0.53% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.
| ONEQ Fidelity Nasdaq Composite Index ETF | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Fidelity | State Street |
| What it is | Nasdaq Composite | SPDR S&P Biotech |
| Total return, 1 year | +20.6% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +3.1 pts | +46.5 pts |
| Expense ratio | 0.21% | 0.35% |
| Already in the S&P 500 | 87.4% | 8.5% |
| Holdings | 1022 | 150 |
ONEQ in plain words
ONEQ is an index equity fund tracking the Nasdaq Composite. Over the year to Sep 11, 2026 it returned +20.6% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.21% a year. By its holdings filed for May 31, 2026, 87% of the fund by weight is stocks the S&P 500 also holds, across 1022 positions, with the top ten at 57.9%.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, ONEQ or XBI?
- In the year to Sep 12, 2026, with distributions reinvested, ONEQ returned +20.6% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, ONEQ or XBI?
- ONEQ charges 0.21% a year and XBI charges 0.35%, so ONEQ is cheaper. Fees come from each fund's prospectus.
- How much do ONEQ and XBI overlap with the S&P 500?
- By their latest filed holdings, 87% of ONEQ and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 3% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, ONEQ against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/ONEQ-XBI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources