Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
XBI vs XLI: how they differ
XBI and XLI hold 0% of their weight in the same names, and XBI returned more over the year.
State Street(R) SPDR(R) S&P(R) Biotech ETF and State Street(R) Industrial Select Sector SPDR(R) ETF.
What they hold in common
By the books each fund has filed, XBI and XLI hold 0% of their money in the same securities at the same weight.
| Only in XBI | Only in XLI |
|---|---|
| Apogee Therapeutics Inc 1.49% | Caterpillar Inc 8.52% |
| Moderna Inc 1.41% | General Electric Co 6.77% |
| Twist Bioscience Corp 1.41% | GE Vernova Inc 5.48% |
| Oruka Therapeutics Inc 1.38% | RTX Corp 4.44% |
| Kymera Therapeutics Inc 1.36% | Boeing Co/The 2.96% |
| Viking Therapeutics Inc 1.31% | Eaton Corp PLC 2.87% |
| Praxis Precision Medicines Inc 1.29% | Union Pacific Corp 2.81% |
| Erasca Inc 1.27% | Deere & Co 2.77% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.
| XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | XLI State Street(R) Industrial Select Sector SPDR(R) ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | State Street | State Street |
| What it is | SPDR S&P Biotech | Industrials |
| Total return, 1 year | +64.0% | +14.3% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +46.5 pts | −3.3 pts |
| Expense ratio | 0.35% | 0.08% |
| Already in the S&P 500 | 8.5% | 100.0% |
| Holdings | 150 | 81 |
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
XLI in plain words
XLI is an index equity fund tracking the Industrials. Over the year to Sep 11, 2026 it returned +14.3% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.08% a year. By its holdings filed for Jun 30, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 81 positions, with the top ten at 41.4%. It sat 7.6% below its high of Aug 14, 2026 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, XBI or XLI?
- In the year to Sep 12, 2026, with distributions reinvested, XBI returned +64.0% and XLI returned +14.3%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, XBI or XLI?
- XBI charges 0.35% a year and XLI charges 0.08%, so XLI is cheaper. Fees come from each fund's prospectus.
- How much do XBI and XLI overlap with the S&P 500?
- By their latest filed holdings, 8% of XBI and 100% of XLI by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, XBI against XLI, data as of Sep 12, 2026. https://etfiq.com/compare/any/XBI-XLI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources