Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
XBI vs XLG: how they differ
XBI and XLG hold 1% of their weight in the same names, and XBI returned more over the year.
State Street(R) SPDR(R) S&P(R) Biotech ETF and Invesco S&P 500 Top 50 ETF.
What they hold in common
By the books each fund has filed, XBI and XLG hold 1% of their money in the same securities at the same weight.
| Holding | XBI | XLG |
|---|---|---|
| AbbVie Inc | 1.04% | 1.01% |
| Only in XBI | Only in XLG |
|---|---|
| Apogee Therapeutics Inc 1.49% | NVIDIA Corp. 13.10% |
| Moderna Inc 1.41% | Apple Inc. 10.76% |
| Twist Bioscience Corp 1.41% | Microsoft Corp. 8.18% |
| Oruka Therapeutics Inc 1.38% | Amazon.com, Inc. 6.99% |
| Kymera Therapeutics Inc 1.36% | Alphabet Inc. 6.05% |
| Viking Therapeutics Inc 1.31% | Broadcom Inc. 4.85% |
| Praxis Precision Medicines Inc 1.29% | Alphabet Inc. 4.82% |
| Erasca Inc 1.27% | Meta Platforms, Inc. 3.61% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jun 30, 2026.
| XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | XLG Invesco S&P 500 Top 50 ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | State Street | Invesco |
| What it is | SPDR S&P Biotech | S&P 500 top 50 |
| Total return, 1 year | +64.0% | +12.2% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +46.5 pts | −5.3 pts |
| Expense ratio | 0.35% | 0.20% |
| Already in the S&P 500 | 8.5% | 100.0% |
| Holdings | 150 | 51 |
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
XLG in plain words
XLG is an index equity fund tracking the S&P 500 top 50. Over the year to Sep 11, 2026 it returned +12.2% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.20% a year. By its holdings filed for Apr 30, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 51 positions, with the top ten at 63.6%.
Questions people ask
- Which returned more over the last year, XBI or XLG?
- In the year to Sep 12, 2026, with distributions reinvested, XBI returned +64.0% and XLG returned +12.2%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, XBI or XLG?
- XBI charges 0.35% a year and XLG charges 0.20%, so XLG is cheaper. Fees come from each fund's prospectus.
- How much do XBI and XLG overlap with the S&P 500?
- By their latest filed holdings, 8% of XBI and 100% of XLG by weight is stocks the S&P 500 already holds. Between the two funds, 1% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, XBI against XLG, data as of Sep 12, 2026. https://etfiq.com/compare/any/XBI-XLG Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources