Which returned more over the last year, VXF or XBI?

In the year to Sep 12, 2026, with distributions reinvested, VXF returned +14.1% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.

Which is cheaper, VXF or XBI?

VXF charges 0.05% a year and XBI charges 0.35%, so VXF is cheaper. Fees come from each fund's prospectus.

How much do VXF and XBI overlap with the S&P 500?

By their latest filed holdings, 0% of VXF and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 7% of their books are the same securities at the same weight.

Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.

ETFIQetfiq.com · independent ETF data

VXF vs XBI: how they differ

VXF and XBI hold 7% of their weight in the same names, and XBI returned more over the year.

Vanguard Extended Market Index Fund and State Street(R) SPDR(R) S&P(R) Biotech ETF.

What they hold in common

By the books each fund has filed, VXF and XBI hold 7% of their money in the same securities at the same weight.

Positions VXF and XBI both hold, largest shared weight first
Holding	VXF	XBI
Alnylam Pharmaceuticals Inc	0.47%	0.96%
Natera Inc	0.46%	1.17%
REVOLUTION Medicines Inc	0.44%	1.21%
Insmed Inc	0.27%	1.08%
United Therapeutics Corp	0.27%	0.93%
Neurocrine Biosciences Inc	0.20%	0.97%
Exelixis Inc	0.16%	0.96%
Ionis Pharmaceuticals Inc	0.15%	1.00%
Bridgebio Pharma Inc	0.15%	1.03%
Cytokinetics Inc	0.14%	1.18%
Arrowhead Pharmaceuticals Inc	0.14%	1.07%
BioMarin Pharmaceutical Inc	0.13%	0.95%

Largest positions each one holds and the other does not
Only in VXF	Only in XBI
Space Exploration Technologies Corp 1.19%	Moderna Inc 1.41%
Snowflake Inc 1.03%	Roivant Sciences Ltd 1.16%
Bloom Energy Corp 0.93%	Alkermes PLC 1.11%
Cloudflare Inc 0.92%	Vertex Pharmaceuticals Inc 1.06%
Astera Labs Inc 0.76%	AbbVie Inc 1.04%
Rocket Lab Corp 0.61%	Biogen Inc 1.03%
Cheniere Energy Inc 0.59%	uniQure NV 1.03%
Ferguson Enterprises Inc 0.54%	CRISPR Therapeutics AG 1.02%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.

VXF and XBI on the fields both publish, as of Sep 12, 2026. Source: ETFIQ.
	VXF Vanguard Extended Market Index Fund	XBI State Street(R) SPDR(R) S&P(R) Biotech ETF
Where it sits	Core index fund	Core index fund
Issuer	Vanguard	State Street
What it is	Extended Market	SPDR S&P Biotech
Total return, 1 year	+14.1%	+64.0%
S&P 500 over the same days	+17.5%	+17.5%
Gap to the S&P 500	−3.4 pts	+46.5 pts
Expense ratio	0.05%	0.35%
Already in the S&P 500	0.0%	8.5%
Holdings	3365	150

VXF in plain words

VXF is an index equity fund tracking the Extended Market. Over the year to Sep 11, 2026 it returned +14.1% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.05% a year. By its holdings filed for Jun 30, 2026, 0% of the fund by weight is stocks the S&P 500 also holds, across 3365 positions, with the top ten at 7.6%. It sat 5.1% below its high of Aug 14, 2026 on Sep 11, 2026.

XBI in plain words

XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.

Questions people ask

Which returned more over the last year, VXF or XBI?: In the year to Sep 12, 2026, with distributions reinvested, VXF returned +14.1% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
Which is cheaper, VXF or XBI?: VXF charges 0.05% a year and XBI charges 0.35%, so VXF is cheaper. Fees come from each fund's prospectus.
How much do VXF and XBI overlap with the S&P 500?: By their latest filed holdings, 0% of VXF and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 7% of their books are the same securities at the same weight.

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Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

VXF against XBI, ETFIQ, data as of Sep 12, 2026. Every figure is arithmetic on a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, VXF against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/VXF-XBI Free to use with attribution; the underlying files are at Open data.

A comparison is not a recommendation. Standards and sources