Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
VTWO vs XBI: how they differ
VTWO and XBI hold 7% of their weight in the same names, and XBI returned more over the year.
Vanguard Russell 2000 Index Fund and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, VTWO and XBI hold 7% of their money in the same securities at the same weight.
| Holding | VTWO | XBI |
|---|---|---|
| Arrowhead Pharmaceuticals Inc | 0.31% | 1.07% |
| Bridgebio Pharma Inc | 0.31% | 1.03% |
| Cytokinetics Inc | 0.29% | 1.18% |
| Praxis Precision Medicines Inc | 0.27% | 1.29% |
| Madrigal Pharmaceuticals Inc | 0.25% | 1.06% |
| Krystal Biotech Inc | 0.23% | 1.10% |
| Vaxcyte Inc | 0.19% | 1.19% |
| PTC Therapeutics Inc | 0.17% | 1.03% |
| Protagonist Therapeutics Inc | 0.17% | 1.08% |
| Nuvalent Inc | 0.16% | 0.93% |
| TG Therapeutics Inc | 0.16% | 1.09% |
| Spyre Therapeutics Inc | 0.16% | 1.10% |
| Only in VTWO | Only in XBI |
|---|---|
| Bloom Energy Corp 1.83% | Moderna Inc 1.41% |
| Credo Technology Group Holding Ltd 1.12% | Viking Therapeutics Inc 1.31% |
| Sterling Infrastructure Inc 0.76% | Revolution Medicines Inc 1.21% |
| Fabrinet 0.69% | Natera Inc 1.17% |
| Nextpower Inc 0.67% | Roivant Sciences Ltd 1.16% |
| IonQ Inc 0.63% | Ultragenyx Pharmaceutical Inc 1.14% |
| Coeur Mining Inc 0.58% | Alkermes PLC 1.11% |
| TTM Technologies Inc 0.52% | Insmed Inc 1.08% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.
| VTWO Vanguard Russell 2000 Index Fund | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Vanguard | State Street |
| What it is | Russell 2000 | SPDR S&P Biotech |
| Total return, 1 year | +21.4% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +3.9 pts | +46.5 pts |
| Expense ratio | 0.07% | 0.35% |
| Already in the S&P 500 | 0.5% | 8.5% |
| Holdings | 1951 | 150 |
VTWO in plain words
VTWO is an index equity fund tracking the Russell 2000. Over the year to Sep 11, 2026 it returned +21.4% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.07% a year. By its holdings filed for May 31, 2026, 0% of the fund by weight is stocks the S&P 500 also holds, across 1951 positions, with the top ten at 7.8%. It sat 5.3% below its high of Aug 14, 2026 on Sep 11, 2026.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, VTWO or XBI?
- In the year to Sep 12, 2026, with distributions reinvested, VTWO returned +21.4% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, VTWO or XBI?
- VTWO charges 0.07% a year and XBI charges 0.35%, so VTWO is cheaper. Fees come from each fund's prospectus.
- How much do VTWO and XBI overlap with the S&P 500?
- By their latest filed holdings, 0% of VTWO and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 7% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, VTWO against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/VTWO-XBI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources