Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
VOO vs XBI: how they differ
VOO and XBI hold 2% of their weight in the same names, and XBI returned more over the year.
Vanguard 500 Index Fund and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, VOO and XBI hold 2% of their money in the same securities at the same weight.
| Holding | VOO | XBI |
|---|---|---|
| AbbVie Inc | 0.69% | 1.04% |
| Amgen Inc | 0.30% | 1.00% |
| Gilead Sciences Inc | 0.24% | 0.97% |
| Vertex Pharmaceuticals Inc | 0.20% | 1.06% |
| Regeneron Pharmaceuticals Inc | 0.10% | 0.96% |
| Biogen Inc | 0.05% | 1.03% |
| Moderna Inc | 0.04% | 1.41% |
| Incyte Corp | 0.03% | 1.00% |
| Only in VOO | Only in XBI |
|---|---|
| NVIDIA Corp 7.53% | Apogee Therapeutics Inc 1.49% |
| Apple Inc 6.61% | Twist Bioscience Corp 1.41% |
| Microsoft Corp 4.31% | Oruka Therapeutics Inc 1.38% |
| Amazon.com Inc 3.63% | Kymera Therapeutics Inc 1.36% |
| Alphabet Inc 3.26% | Viking Therapeutics Inc 1.31% |
| Broadcom Inc 2.78% | Praxis Precision Medicines Inc 1.29% |
| Alphabet Inc 2.60% | Erasca Inc 1.27% |
| Micron Technology Inc 2.02% | Revolution Medicines Inc 1.21% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.
| VOO Vanguard 500 Index Fund | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Vanguard | State Street |
| What it is | S&P 500 | SPDR S&P Biotech |
| Total return, 1 year | +17.6% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +0.1 pts | +46.5 pts |
| Expense ratio | 0.03% | 0.35% |
| Already in the S&P 500 | 100.0% | 8.5% |
| Holdings | 506 | 150 |
VOO in plain words
VOO is an index equity fund tracking the S&P 500. Over the year to Sep 11, 2026 it returned +17.6% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.03% a year. By its holdings filed for Jun 30, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 506 positions, with the top ten at 36.5%.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, VOO or XBI?
- In the year to Sep 12, 2026, with distributions reinvested, VOO returned +17.6% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, VOO or XBI?
- VOO charges 0.03% a year and XBI charges 0.35%, so VOO is cheaper. Fees come from each fund's prospectus.
- How much do VOO and XBI overlap with the S&P 500?
- By their latest filed holdings, 100% of VOO and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 2% of their books are the same securities at the same weight.
Other comparisons
Where to next
Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, VOO against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/VOO-XBI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources