Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
QQQ vs XBI: how they differ
QQQ and XBI hold 3% of their weight in the same names, and XBI returned more over the year.
Invesco QQQ Trust and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, QQQ and XBI hold 3% of their money in the same securities at the same weight.
| Holding | QQQ | XBI |
|---|---|---|
| Amgen Inc. | 0.80% | 1.00% |
| Gilead Sciences, Inc. | 0.73% | 0.97% |
| Vertex Pharmaceuticals Inc. | 0.50% | 1.06% |
| Regeneron Pharmaceuticals, Inc. | 0.28% | 0.96% |
| Alnylam Pharmaceuticals, Inc. | 0.18% | 0.96% |
| Insmed Inc. | 0.10% | 1.08% |
| Only in QQQ | Only in XBI |
|---|---|
| NVIDIA Corp. 8.16% | Apogee Therapeutics Inc 1.49% |
| Apple Inc. 7.29% | Moderna Inc 1.41% |
| Microsoft Corp. 5.32% | Twist Bioscience Corp 1.41% |
| Micron Technology, Inc. 4.80% | Oruka Therapeutics Inc 1.38% |
| Amazon.com, Inc. 4.62% | Kymera Therapeutics Inc 1.36% |
| Advanced Micro Devices, Inc. 3.70% | Viking Therapeutics Inc 1.31% |
| Alphabet Inc. 3.52% | Praxis Precision Medicines Inc 1.29% |
| Tesla, Inc. 3.46% | Erasca Inc 1.27% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.
| QQQ Invesco QQQ Trust | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Invesco | State Street |
| What it is | Nasdaq-100, book from QQQM | SPDR S&P Biotech |
| Total return, 1 year | +23.0% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +5.5 pts | +46.5 pts |
| Expense ratio | 0.18% | 0.35% |
| Already in the S&P 500 | 96.7% | 8.5% |
| Holdings | 101 | 150 |
QQQ in plain words
QQQ is an index equity fund tracking the Nasdaq-100. Over the year to Sep 11, 2026 it returned +23.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.18% a year. By its holdings filed for May 31, 2026, 97% of the fund by weight is stocks the S&P 500 also holds, across 101 positions, with the top ten at 47.5%. It sat 4.1% below its high of Jun 2, 2026 on Sep 11, 2026.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, QQQ or XBI?
- In the year to Sep 12, 2026, with distributions reinvested, QQQ returned +23.0% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, QQQ or XBI?
- QQQ charges 0.18% a year and XBI charges 0.35%, so QQQ is cheaper. Fees come from each fund's prospectus.
- How much do QQQ and XBI overlap with the S&P 500?
- By their latest filed holdings, 97% of QQQ and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 3% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, QQQ against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/QQQ-XBI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources