Which returned more over the last year, IUSB or XBI?

In the year to Sep 12, 2026, with distributions reinvested, IUSB returned −0.3% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.

Which is cheaper, IUSB or XBI?

IUSB charges 0.06% a year and XBI charges 0.35%, so IUSB is cheaper. Fees come from each fund's prospectus.

Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.

ETFIQetfiq.com · independent ETF data

IUSB vs XBI: how they differ

IUSB and XBI hold 0% of their weight in the same names, and XBI returned more over the year.

iShares Core Universal USD Bond ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.

What they hold in common

By the books each fund has filed, IUSB and XBI hold 0% of their money in the same securities at the same weight.

Largest positions each one holds and the other does not
Only in IUSB	Only in XBI
United States of America 0.38%	Apogee Therapeutics Inc 1.49%
United States of America 0.37%	Moderna Inc 1.41%
United States of America 0.37%	Twist Bioscience Corp 1.41%
United States of America 0.37%	Oruka Therapeutics Inc 1.38%
United States of America 0.36%	Kymera Therapeutics Inc 1.36%
United States of America 0.36%	Viking Therapeutics Inc 1.31%
United States of America 0.36%	Praxis Precision Medicines Inc 1.29%
United States of America 0.35%	Erasca Inc 1.27%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jun 30, 2026.

IUSB and XBI on the fields both publish, as of Sep 12, 2026. Source: ETFIQ.
	IUSB iShares Core Universal USD Bond ETF	XBI State Street(R) SPDR(R) S&P(R) Biotech ETF
Where it sits	Core index fund	Core index fund
Issuer	iShares	State Street
What it is	Core Universal USD Bond	SPDR S&P Biotech
Total return, 1 year	−0.3%	+64.0%
S&P 500 over the same days	+17.5%	+17.5%
Gap to the S&P 500	−17.8 pts	+46.5 pts
Expense ratio	0.06%	0.35%
Holdings	17819	150

IUSB in plain words

IUSB is a bond fund tracking the Core Universal USD Bond. Over the year to Sep 11, 2026 it returned −0.3% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.06% a year.

XBI in plain words

XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.

Questions people ask

Which returned more over the last year, IUSB or XBI?: In the year to Sep 12, 2026, with distributions reinvested, IUSB returned −0.3% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
Which is cheaper, IUSB or XBI?: IUSB charges 0.06% a year and XBI charges 0.35%, so IUSB is cheaper. Fees come from each fund's prospectus.

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Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

IUSB against XBI, ETFIQ, data as of Sep 12, 2026. Every figure is arithmetic on a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, IUSB against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/IUSB-XBI Free to use with attribution; the underlying files are at Open data.

A comparison is not a recommendation. Standards and sources