Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs VTI: how they differ
IBB and VTI hold 2% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and Vanguard Total Stock Market Index Fund.
What they hold in common
By the books each fund has filed, IBB and VTI hold 2% of their money in the same securities at the same weight.
| Holding | IBB | VTI |
|---|---|---|
| Amgen, Inc. | 7.84% | 0.27% |
| Gilead Sciences, Inc. | 6.85% | 0.22% |
| Vertex Pharmaceuticals, Inc. | 8.09% | 0.17% |
| Regeneron Pharmaceuticals, Inc. | 4.91% | 0.09% |
| Alnylam Pharmaceuticals, Inc. | 3.12% | 0.06% |
| Revolution Medicines, Inc. | 2.78% | 0.05% |
| Natera, Inc. | 2.89% | 0.05% |
| Biogen, Inc. | 2.47% | 0.04% |
| Illumina, Inc. | 2.07% | 0.04% |
| Moderna, Inc. | 1.99% | 0.04% |
| Insmed, Inc. | 1.79% | 0.03% |
| United Therapeutics Corp. | 1.74% | 0.03% |
| Only in IBB | Only in VTI |
|---|---|
| Argenx SE 3.76% | NVIDIA Corp 6.37% |
| BeOne Medicines Ltd. 1.77% | Apple Inc 5.88% |
| Roivant Sciences Ltd. 1.43% | Microsoft Corp 3.84% |
| Ascendis Pharma A/S 1.29% | Amazon.com Inc 3.19% |
| Genmab A/S 1.12% | Alphabet Inc 2.90% |
| Abivax SA 0.67% | Broadcom Inc 2.48% |
| Alkermes plc 0.67% | Alphabet Inc 2.29% |
| BioNTech SE 0.66% | Micron Technology Inc 1.80% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.
| IBB iShares Biotechnology ETF | VTI Vanguard Total Stock Market Index Fund | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | Vanguard |
| What it is | Biotechnology | US total market |
| Total return, 1 year | +41.5% | +17.2% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | −0.3 pts |
| Expense ratio | 0.44% | 0.03% |
| Already in the S&P 500 | 35.6% | 88.3% |
| Holdings | 248 | 3531 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
VTI in plain words
VTI is an index equity fund tracking the US total market. Over the year to Sep 11, 2026 it returned +17.2% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.03% a year. By its holdings filed for Jun 30, 2026, 88% of the fund by weight is stocks the S&P 500 also holds, across 3531 positions, with the top ten at 32.1%.
Questions people ask
- Which returned more over the last year, IBB or VTI?
- In the year to Sep 12, 2026, with distributions reinvested, IBB returned +41.5% and VTI returned +17.2%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or VTI?
- IBB charges 0.44% a year and VTI charges 0.03%, so VTI is cheaper. Fees come from each fund's prospectus.
- How much do IBB and VTI overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 88% of VTI by weight is stocks the S&P 500 already holds. Between the two funds, 2% of their books are the same securities at the same weight.
Other comparisons
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against VTI, data as of Sep 12, 2026. https://etfiq.com/compare/any/IBB-VTI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources