Get the weekly note

Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.

ETFIQetfiq.com · independent ETF data

IBB vs VGSH: how they differ

IBB and VGSH hold 0% of their weight in the same names, and IBB returned more over the year.

iShares Biotechnology ETF and Vanguard Short-Term Treasury Index Fund.

What they hold in common

By the books each fund has filed, IBB and VGSH hold 0% of their money in the same securities at the same weight.

Largest positions each one holds and the other does not
Only in IBBOnly in VGSH
Vertex Pharmaceuticals, Inc. 8.09%United States Treasury Note/Bond 2.26%
Amgen, Inc. 7.84%United States Treasury Note/Bond 1.41%
Gilead Sciences, Inc. 6.85%United States Treasury Note/Bond 1.36%
Regeneron Pharmaceuticals, Inc. 4.91%United States Treasury Note/Bond 1.32%
Argenx SE 3.76%United States Treasury Note/Bond 1.31%
Alnylam Pharmaceuticals, Inc. 3.12%United States Treasury Note/Bond 1.30%
Natera, Inc. 2.89%United States Treasury Note/Bond 1.27%
Revolution Medicines, Inc. 2.78%United States Treasury Note/Bond 1.27%

Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026 and May 31, 2026.

IBB and VGSH on the fields both publish, as of Sep 12, 2026. Source: ETFIQ.
IBB
iShares Biotechnology ETF
VGSH
Vanguard Short-Term Treasury Index Fund
Where it sitsCore index fundCore index fund
IssueriSharesVanguard
What it isBiotechnologyShort-Term Treasury
Total return, 1 year+41.5%+1.8%
S&P 500 over the same days+17.5%+17.5%
Gap to the S&P 500+24.0 pts−15.7 pts
Expense ratio0.44%0.03%
Holdings24891

IBB in plain words

IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.

VGSH in plain words

VGSH is a bond fund tracking the Short-Term Treasury. Over the year to Sep 11, 2026 it returned +1.8% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.03% a year.

Questions people ask

Which returned more over the last year, IBB or VGSH?
In the year to Sep 12, 2026, with distributions reinvested, IBB returned +41.5% and VGSH returned +1.8%, so IBB returned more. One year is one year; the longer windows are in the table.
Which is cheaper, IBB or VGSH?
IBB charges 0.44% a year and VGSH charges 0.03%, so VGSH is cheaper. Fees come from each fund's prospectus.

Other comparisons

Where to next

Where these figures came from

ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.

IBB against VGSH, ETFIQ, data as of Sep 12, 2026. Every figure is arithmetic on a named public source; the method is at etfiq.com/methodology. A comparison is not a recommendation.

Cite this page. ETFIQ, IBB against VGSH, data as of Sep 12, 2026. https://etfiq.com/compare/any/IBB-VGSH Free to use with attribution; the underlying files are at Open data.

A comparison is not a recommendation. Standards and sources