Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs USMV: how they differ
IBB and USMV hold 4% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and iShares MSCI USA Min Vol Factor ETF.
What they hold in common
By the books each fund has filed, IBB and USMV hold 4% of their money in the same securities at the same weight.
| Holding | IBB | USMV |
|---|---|---|
| Vertex Pharmaceuticals, Inc. | 8.09% | 1.36% |
| Gilead Sciences, Inc. | 6.85% | 0.82% |
| Incyte Corp. | 1.75% | 0.54% |
| Amgen, Inc. | 7.84% | 0.31% |
| Alnylam Pharmaceuticals, Inc. | 3.12% | 0.31% |
| Neurocrine Biosciences, Inc. | 1.30% | 0.31% |
| United Therapeutics Corp. | 1.74% | 0.21% |
| Regeneron Pharmaceuticals, Inc. | 4.91% | 0.07% |
| Only in IBB | Only in USMV |
|---|---|
| Argenx SE 3.76% | CISCO SYSTEMS, INC. 1.81% |
| Natera, Inc. 2.89% | NVIDIA CORPORATION 1.64% |
| Revolution Medicines, Inc. 2.78% | EXXON MOBIL CORPORATION 1.60% |
| Biogen, Inc. 2.47% | MICROSOFT CORPORATION 1.56% |
| Illumina, Inc. 2.07% | DUKE ENERGY CORPORATION 1.55% |
| Moderna, Inc. 1.99% | THE SOUTHERN COMPANY 1.53% |
| Insmed, Inc. 1.79% | AMPHENOL CORPORATION 1.51% |
| BeOne Medicines Ltd. 1.77% | Chubb Limited 1.50% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jun 30, 2026.
| IBB iShares Biotechnology ETF | USMV iShares MSCI USA Min Vol Factor ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | iShares |
| What it is | Biotechnology | MSCI USA Min Vol Factor |
| Total return, 1 year | +41.5% | +6.6% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | −10.9 pts |
| Expense ratio | 0.44% | 0.15% |
| Already in the S&P 500 | 35.6% | 94.8% |
| Holdings | 248 | 170 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
USMV in plain words
USMV is an index equity fund tracking the MSCI USA Min Vol Factor. Over the year to Sep 11, 2026 it returned +6.6% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.15% a year. By its holdings filed for Apr 30, 2026, 95% of the fund by weight is stocks the S&P 500 also holds, across 170 positions, with the top ten at 15.7%.
Questions people ask
- Which returned more over the last year, IBB or USMV?
- In the year to Sep 12, 2026, with distributions reinvested, IBB returned +41.5% and USMV returned +6.6%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or USMV?
- IBB charges 0.44% a year and USMV charges 0.15%, so USMV is cheaper. Fees come from each fund's prospectus.
- How much do IBB and USMV overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 95% of USMV by weight is stocks the S&P 500 already holds. Between the two funds, 4% of their books are the same securities at the same weight.
Other comparisons
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against USMV, data as of Sep 12, 2026. https://etfiq.com/compare/any/IBB-USMV Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources