Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs SPYG: how they differ
IBB and SPYG hold 1% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and State Street(R) SPDR(R) Portfolio S&P 500(R) Growth ETF.
What they hold in common
By the books each fund has filed, IBB and SPYG hold 1% of their money in the same securities at the same weight.
| Holding | IBB | SPYG |
|---|---|---|
| Amgen, Inc. | 7.84% | 0.38% |
| Gilead Sciences, Inc. | 6.85% | 0.24% |
| Incyte Corp. | 1.75% | 0.05% |
| Only in IBB | Only in SPYG |
|---|---|
| Vertex Pharmaceuticals, Inc. 8.09% | NVIDIA Corp 13.66% |
| Regeneron Pharmaceuticals, Inc. 4.91% | Microsoft Corp 7.81% |
| Argenx SE 3.76% | Apple Inc 5.99% |
| Alnylam Pharmaceuticals, Inc. 3.12% | Alphabet Inc 5.91% |
| Natera, Inc. 2.89% | Broadcom Inc 5.04% |
| Revolution Medicines, Inc. 2.78% | Alphabet Inc 4.71% |
| Biogen, Inc. 2.47% | Micron Technology Inc 3.67% |
| Illumina, Inc. 2.07% | Meta Platforms Inc 3.49% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.
| IBB iShares Biotechnology ETF | SPYG State Street(R) SPDR(R) Portfolio S&P 500(R) Growth ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | State Street |
| What it is | Biotechnology | SPDR Portfolio S&P 500 Growth |
| Total return, 1 year | +41.5% | +17.9% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | +0.4 pts |
| Expense ratio | 0.44% | 0.04% |
| Already in the S&P 500 | 35.6% | 100.0% |
| Holdings | 248 | 147 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
SPYG in plain words
SPYG is an index equity fund tracking the SPDR Portfolio S&P 500 Growth. Over the year to Sep 11, 2026 it returned +17.9% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.04% a year. By its holdings filed for Jun 30, 2026, 100% of the fund by weight is stocks the S&P 500 also holds, across 147 positions, with the top ten at 56.4%.
Questions people ask
- Which returned more over the last year, IBB or SPYG?
- In the year to Sep 12, 2026, with distributions reinvested, IBB returned +41.5% and SPYG returned +17.9%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or SPYG?
- IBB charges 0.44% a year and SPYG charges 0.04%, so SPYG is cheaper. Fees come from each fund's prospectus.
- How much do IBB and SPYG overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 100% of SPYG by weight is stocks the S&P 500 already holds. Between the two funds, 1% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against SPYG, data as of Sep 12, 2026. https://etfiq.com/compare/any/IBB-SPYG Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources