Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
IBB vs IYR: how they differ
IBB and IYR hold 0% of their weight in the same names, and IBB returned more over the year.
iShares Biotechnology ETF and iShares U.S. Real Estate ETF.
What they hold in common
By the books each fund has filed, IBB and IYR hold 0% of their money in the same securities at the same weight.
| Only in IBB | Only in IYR |
|---|---|
| Vertex Pharmaceuticals, Inc. 8.09% | WELLTOWER INC. 10.88% |
| Amgen, Inc. 7.84% | PROLOGIS, INC. 8.77% |
| Gilead Sciences, Inc. 6.85% | SIMON PROPERTY GROUP, INC. 4.79% |
| Regeneron Pharmaceuticals, Inc. 4.91% | EQUINIX, INC. 4.58% |
| Argenx SE 3.76% | DIGITAL REALTY TRUST, INC. 4.41% |
| Alnylam Pharmaceuticals, Inc. 3.12% | REALTY INCOME CORPORATION 4.29% |
| Natera, Inc. 2.89% | AMERICAN TOWER CORPORATION 3.88% |
| Revolution Medicines, Inc. 2.78% | PUBLIC STORAGE. 3.74% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Jun 30, 2026.
| IBB iShares Biotechnology ETF | IYR iShares U.S. Real Estate ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | iShares |
| What it is | Biotechnology | U.S. Real Estate |
| Total return, 1 year | +41.5% | +4.7% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | +24.0 pts | −12.8 pts |
| Expense ratio | 0.44% | 0.37% |
| Already in the S&P 500 | 35.6% | 80.4% |
| Holdings | 248 | 61 |
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
IYR in plain words
IYR is an index equity fund tracking the U.S. Real Estate. Over the year to Sep 11, 2026 it returned +4.7% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.37% a year. By its holdings filed for Jun 30, 2026, 80% of the fund by weight is stocks the S&P 500 also holds, across 61 positions, with the top ten at 51.5%. It sat 6.1% below its high of Jul 28, 2026 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, IBB or IYR?
- In the year to Sep 12, 2026, with distributions reinvested, IBB returned +41.5% and IYR returned +4.7%, so IBB returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, IBB or IYR?
- IBB charges 0.44% a year and IYR charges 0.37%, so IYR is cheaper. Fees come from each fund's prospectus.
- How much do IBB and IYR overlap with the S&P 500?
- By their latest filed holdings, 36% of IBB and 80% of IYR by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IBB against IYR, data as of Sep 12, 2026. https://etfiq.com/compare/any/IBB-IYR Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources