Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
IALT vs IBB: how they differ
IALT and IBB hold 0% of their weight in the same names.
iShares Systematic Alternatives Active ETF and iShares Biotechnology ETF.
What they hold in common
By the books each fund has filed, IALT and IBB hold 0% of their money in the same securities at the same weight.
| Only in IALT | Only in IBB |
|---|---|
| Intercontinental Exchange, Inc. 17.26% | Vertex Pharmaceuticals, Inc. 8.09% |
| PRIME SECSRVC BRW/FINANC 1.29% | Amgen, Inc. 7.84% |
| PHINIA INC 0.94% | Gilead Sciences, Inc. 6.85% |
| DISH DBS CORP 0.21% | Regeneron Pharmaceuticals, Inc. 4.91% |
| DISH DBS CORP 0.19% | Argenx SE 3.76% |
| DISH DBS CORP 0.10% | Alnylam Pharmaceuticals, Inc. 3.12% |
| Natera, Inc. 2.89% | |
| Revolution Medicines, Inc. 2.78% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jun 30, 2026.
| IALT iShares Systematic Alternatives Active ETF | IBB iShares Biotechnology ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | iShares | iShares |
| What it is | Systematic Alternatives Active | Biotechnology |
| Total return, 1 year | +17.4% | +41.5% |
| S&P 500 over the same days | +12.1% | +17.5% |
| Gap to the S&P 500 | +5.4 pts | +24.0 pts |
| Expense ratio | not published | 0.44% |
| Already in the S&P 500 | 54.9% | 35.6% |
| Holdings | 8 | 248 |
IALT in plain words
IALT is an index equity fund tracking the Systematic Alternatives Active. By its holdings filed for Apr 30, 2026, 55% of the fund by weight is stocks the S&P 500 also holds, across 8 positions, with the top ten at 100.0%.
IBB in plain words
IBB is an index equity fund tracking the Biotechnology. Over the year to Sep 11, 2026 it returned +41.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.44% a year. By its holdings filed for Jun 30, 2026, 36% of the fund by weight is stocks the S&P 500 also holds, across 248 positions, with the top ten at 44.8%. It sat 6.5% below its high of Aug 19, 2026 on Sep 11, 2026.
Questions people ask
- How much do IALT and IBB overlap with the S&P 500?
- By their latest filed holdings, 55% of IALT and 36% of IBB by weight is stocks the S&P 500 already holds. Between the two funds, 0% of their books are the same securities at the same weight.
Other comparisons
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, IALT against IBB, data as of Sep 12, 2026. https://etfiq.com/compare/any/IALT-IBB Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources