Data as of Sep 12, 2026. Both funds on the fields they both publish, from the same sources.
DFUS vs XBI: how they differ
DFUS and XBI hold 2% of their weight in the same names, and XBI returned more over the year.
Dimensional U.S. Equity Market ETF and State Street(R) SPDR(R) S&P(R) Biotech ETF.
What they hold in common
By the books each fund has filed, DFUS and XBI hold 2% of their money in the same securities at the same weight.
| Holding | DFUS | XBI |
|---|---|---|
| ABBVIE INC. | 0.56% | 1.04% |
| AMGEN INC. | 0.28% | 1.00% |
| GILEAD SCIENCES, INC. | 0.24% | 0.97% |
| VERTEX PHARMACEUTICALS INCORPORATED | 0.16% | 1.06% |
| REGENERON PHARMACEUTICALS, INC. | 0.11% | 0.96% |
| ALNYLAM PHARMACEUTICALS, INC. | 0.07% | 0.96% |
| INSMED INCORPORATED | 0.04% | 1.08% |
| BIOGEN INC. | 0.04% | 1.03% |
| NATERA, INC. | 0.04% | 1.17% |
| UNITED THERAPEUTICS CORPORATION | 0.04% | 0.93% |
| REVOLUTION MEDICINES, INC. | 0.03% | 1.21% |
| MODERNA, INC. | 0.03% | 1.41% |
| Only in DFUS | Only in XBI |
|---|---|
| NVIDIA CORPORATION 6.97% | Apogee Therapeutics Inc 1.49% |
| APPLE INC. 5.86% | Rhythm Pharmaceuticals Inc 1.20% |
| MICROSOFT CORPORATION 4.52% | SELLAS Life Sciences Group Inc 1.19% |
| AMAZON.COM, INC. 3.84% | Cytokinetics Inc 1.18% |
| ALPHABET INC. 3.31% | Scholar Rock Holding Corp 1.16% |
| BROADCOM INC. 2.90% | Mirum Pharmaceuticals Inc 1.16% |
| ALPHABET INC. 2.74% | Roivant Sciences Ltd 1.16% |
| META PLATFORMS, INC. 2.01% | Cogent Biosciences Inc 1.15% |
Weight overlap is an ETFIQ calculation: for every security both funds hold, the smaller of the two weights, summed. Above 50%, holding both is close to holding one of them twice. Holdings dated Apr 30, 2026 and Jun 30, 2026.
| DFUS Dimensional U.S. Equity Market ETF | XBI State Street(R) SPDR(R) S&P(R) Biotech ETF | |
|---|---|---|
| Where it sits | Core index fund | Core index fund |
| Issuer | Dimensional | State Street |
| What it is | U.S. Equity Market | SPDR S&P Biotech |
| Total return, 1 year | +17.5% | +64.0% |
| S&P 500 over the same days | +17.5% | +17.5% |
| Gap to the S&P 500 | 0.0 pts | +46.5 pts |
| Expense ratio | 0.09% | 0.35% |
| Already in the S&P 500 | 90.2% | 8.5% |
| Holdings | 2231 | 150 |
DFUS in plain words
DFUS is an index equity fund tracking the U.S. Equity Market. Over the year to Sep 11, 2026 it returned +17.5% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.09% a year. By its holdings filed for Apr 30, 2026, 90% of the fund by weight is stocks the S&P 500 also holds, across 2231 positions, with the top ten at 35.2%.
XBI in plain words
XBI is an index equity fund tracking the SPDR S&P Biotech. Over the year to Sep 11, 2026 it returned +64.0% with distributions reinvested, against +17.5% for the S&P 500 and +23.0% for the Nasdaq-100. The prospectus expense ratio is 0.35% a year. By its holdings filed for Jun 30, 2026, 8% of the fund by weight is stocks the S&P 500 also holds, across 150 positions, with the top ten at 13.3%. It sat 9.6% below its high of Feb 8, 2021 on Sep 11, 2026.
Questions people ask
- Which returned more over the last year, DFUS or XBI?
- In the year to Sep 12, 2026, with distributions reinvested, DFUS returned +17.5% and XBI returned +64.0%, so XBI returned more. One year is one year; the longer windows are in the table.
- Which is cheaper, DFUS or XBI?
- DFUS charges 0.09% a year and XBI charges 0.35%, so DFUS is cheaper. Fees come from each fund's prospectus.
- How much do DFUS and XBI overlap with the S&P 500?
- By their latest filed holdings, 90% of DFUS and 8% of XBI by weight is stocks the S&P 500 already holds. Between the two funds, 2% of their books are the same securities at the same weight.
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Where these figures came from
ETFIQ links to the documents behind every figure. It is not affiliated with any issuer, and a link is not an endorsement.
Cite this page. ETFIQ, DFUS against XBI, data as of Sep 12, 2026. https://etfiq.com/compare/any/DFUS-XBI Free to use with attribution; the underlying files are at Open data.
A comparison is not a recommendation. Standards and sources